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A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

RESEARCH AREAS > Research Staff Details

Nanomedicine

   

KURISAWA Motoichi
Team Leader and Principal Research Scientist

Tel: 6824 7139
Email: mkurisawa@ibn.a-star.edu.sg

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Postdoctoral Fellow, Kyoto University (Japan), 2003
Postdoctoral Fellow, Bio-Oriented Technology Research Advancement Institute, 2000-2003
Postdoctoral Fellow, Tokyo Women's Medical University (Japan), 1998-2000

Ph.D. in Materials Science, Japan Advanced Institute of Science and Technology, 1998
M.Sc. in Materials Science, Japan Advanced Institute of Science and Technology, 1995
B.Sc. in Engineering, Yamagata University, 1992

Projects Publications Patents

Nanomedicine

1. Injectable Biodegradable Hydrogels for Drug Delivery and Tissue Engineering

Fan Lee, Ki Hyun Bae, Atsushi Yamashita, Chixuan Liu, Li Li, Shengyong Ng, Susi Tan, Joo Eun Chung and Motoichi Kurisawa

Hydrogels are soft materials with high water content. IBN researchers have developed a novel gel that can encapsulate therapeutic proteins, growth factors and cells for drug delivery and tissue regeneration. The hydrogels are biodegradable, made of non-toxic materials and can be injected into the body. They can regulate the rate of drug release in the body over a specific period, and reduce the need for frequent injections. These new materials show tremendous potential for improved treatment of cancer and neurological disorders. They can also be used as a scaffold to grow new tissues.

2. Using Green Tea Nanocomplex to Fight Cancer

Joo Eun Chung, Susi Tan, Kun Liang, Nunnarpas Yongvongsoontorn, Atsushi Yamashita, Li Li, Shengyong Ng, Shujun Gao, Lucky Swarnalatha Sasidharan, Rachel Sim, Min-Han Tan, Motoichi Kurisawa and Jackie Y. Ying

Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. IBN has taken the health benefits of green tea to the next level by using one of its key compounds, epigallocatechin gallate (EGCG), to develop micellar nanocomplexes for delivering anti-cancer protein drugs. The nanocarrier is formed by complexation of oligomerized EGCG with the protein drugs to form the core, followed by complexation of poly(ethylene glycol)–EGCG to form the shell. The micellar nanocomplexes protect the protein drugs from rapid proteolysis and renal clearance, while providing for tumor targeting. This green tea nanocarrier reduces tumor growth more effectively than using the drug by itself. We are also exploring the delivery of active ingredients in personal care and nutritional products using the micellar nanocomplexes.

EVENTS

2017
6 Dec - 10 Dec
5th Nano Today Conference

Event Calendar   

One-North Run 2017

FEATURED PUBLICATIONS

Combinatorial Evolution of Fast-Conducting Highly Selective K+- Channels via Modularly Tunable Directional Assembly of Crown Ethers
Journal of the American Chemical Society, (2017)
DOI: 10.1021/jacs.7b04335.
(IF: 13.858) article

Molecular Characterization of Circulating Colorectal Tumor Cells Defines Genetic Signatures for Individualized Cancer Care
Oncotarget, (2017)
DOI: 10.18632/oncotarget.19138.
(IF: 5.168) article

Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts
Molecular Cancer Therapeutics, (2017)
DOI: 10.1158/1535-7163.MCT-16-0793.
(IF: 5.764) article

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