A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

RESEARCH AREAS > Research Staff Details

Biodevices and Diagnostics


HIRAO Ichiro
Team Leader and Principal Research Scientist

Tel: 6824 7104
Email: ichiro@ibn.a-star.edu.sg

View CV

Team Leader, RIKEN (Japan), 2006-2015
Professor, Research Center for Advanced Science and Technology, The University of Tokyo (Japan), 2002-2006
Associate Scientist, Department of Chemistry, Indiana University (USA), 1995-1997

Ph.D. in Chemistry, Tokyo Institute of Technology, 1983
M.A. in Chemistry, Tokyo Institute of Technology, 1980
B.S. in Industrial Chemistry, Shizuoka University, 1978

Projects Publications Patents

Biodevices and Diagnostics

1. Genetic Alphabet Expansion using Unnatural Base Pair Systems

Michiko Kimoto, Itaru Okamoto, Kiyofumi Hamashima, Ken-ichiro Matsunaga and Ichiro Hirao

The genetic information flow of the central dogma relies on only four nucleobases, which in turn constrains the Darwinian evolution of nucleic acids and proteins as functional molecules. IBN is developing a genetic alphabet expansion technology of DNA by creating extra base pairs, called unnatural base pairs. The unnatural base pairs exhibit high fidelity and efficiency in replication and/or transcription as a third base pair. The unnatural base pair systems can be used in a wide variety of biotechnology applications, such as PCR detection and aptamer generation.

2. High-Affinity DNA Aptamer Generation

Michiko Kimoto, Itaru Okamoto, Kiyofumi Hamashima, Nur-Afidah Binte Mohamed Suhaimi, Ken-ichiro Matsunaga and Ichiro Hirao

IBN has successfully generated high-affinity DNA aptamers that bind to target proteins and cells by a new evolutionary engineering method called ExSELEX (genetic alphabet Expansion for Systematic Evolution of Ligands by EXponential enrichment) using our unnatural base pair technology. We have also created another technology, called mini-hairpin, to stabilize high-affinity DNA aptamers against heat and nucleases. We are developing diagnostic and therapeutic methods using these new technologies for cancer and infectious diseases.


23 Jan
IBN Seminar Series: Conformational Communication: Design and Synthesis of Membrane-Bound Receptor Mimics by Prof. Jonathan Clayden, University of Bristol, UK

Event Calendar   


Graphene Oxide-Templated Synthesis of Ternary Oxide Nanosheets for High Performance Li-ion Battery Anodes
Nano Energy, 44 (2018) 399-410.
(IF: 12.343) article

Hexaazatrinaphthylene-Based Porous Organic Polymers as Organic Cathode Materials for Lithium Ion Battery
ACS Sustainable Chemistry and Engineering, (2017)
DOI: 10.1021/acssuschemeng.7b03165.
(IF: 5.951) article

Highly Efficient Gas Phase Oxidation of Renewable Furfural to Maleic Anhydride over Plate VPO Catalyst
ChemSusChem, (2017)
DOI: 10.1002/cssc.201701866.
(IF: 7.226) article



Research Positions

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