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A*STAR Outstanding Publications Award 2009, 2010, 2012, 2013 and 2014
A*STAR Patent Power Award 2009 and 2010
Singapore HEALTH Award (Platinum) 2012, (Gold) 2008 and 2010

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RESEARCH AREAS > Research Staff Details

Nanomedicine

   

YANG Yi Yan
Group Leader

Tel: 6824 7106
Email: yyyang@ibn.a-star.edu.sg

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Adjunct Associate Professor, Department of Pharmacy, National University of Singapore, 2008-present
Visiting Scientist/Research Fellow/Senior Research Fellow, Institute of Materials Research & Engineering (Singapore), 1998-2003
Assistant/Associate Professor, 1990-1998

Ph.D. in Chemical Engineering, Tsinghua University (China), 1990
B.E. in Chemical Engineering, Hefei University of Technology (China), 1985

Projects Publications Patents

Nanomedicine

1. Macromolecular Antimicrobials to Combat Microbes

Chuan Yang, Wei Cheng, Noel Xu, Xin Ding, Shaoqiong Liu, Ashlynn Lee, Majad Khan, Shrinivas Venkataraman, Jeremy Tan, Nor Lizawati Ibrahim, Willy Chin, David Voo, Shujun Gao, Yuan Yuan, Hong Wu, Jackie Y. Ying, Yugen Zhang and Yi Yan Yang

The increasing prevalence of antibiotic resistant infections, such as Methicillin-resistant Staphylococcus aureus (MRSA), has sparked off a pressing need for innovative antimicrobial treatments. IBN has developed a new class of antimicrobial polymers and peptides that can provide a new arsenal against superbugs. Most modern-day antibiotics act on specific molecular targets within the bacteria. While this yields therapeutic specificity, it also allows resistance development through mutation since the bacterial cell structure is generally preserved. The antimicrobial macromolecules are biodegradable, biocompatible and have broad-spectrum antimicrobial activities against bacteria, yeast and fungi, to destroy multidrug-resistant microbes and prevent drug resistance development.

2. Polymeric Nanoparticles for Targeted Drug Delivery towards Cancer Cells and Cancer Stem Cells

Jeremy Tan, Xiyu Ke, Jye Yng Teo, Eunice Leong, Pei Yun Teo, Ashlynn Lee, Martin Nurmik, Shaoqiong Liu, Chuan Yang, Shrinivas Venkataraman, Nor Lizawati Ibrahim, Shujun Gao and Yi Yan Yang

We aim to develop safe polymer-based nanocarriers with narrow size distribution, high drug loading capacity and in vivo stability to transport small molecular anti-cancer drugs to cancer cells and cancer stem cells that are responsible for tumor relapse and metastasis. Biodegradable polymer nanoparticles that can interact with the drugs have been synthesized. A number of platform technologies have been developed to deliver a variety of drugs, proteins and genes. These co-delivery nanosized formulations have the potential to improve cancer therapy, prevent relapse and metastasis.

EVENTS

2015
2 Jul
IBN Seminar Series: Molecular Evolutionary Engineering for Creation of Functional Biomolecules by Dr. Yoshihiro Ito, RIKEN, Japan

6 Dec - 10 Dec
4th Nano Today Conference

Event Calendar   

FEATURED PUBLICATIONS

NEW! Enzyme-Mediated Hyaluronic Acid–Tyramine Hydrogels for the Propagation of Human Embryonic Stem Cells in 3D
Acta Biomaterialia, (2015)
DOI: 10.1016/j.actbio.2015.06.026.
(IF: 6.025) article

NEW! Microstructured Dextran Hydrogels for Burst-Free Sustained Release of PEGylated Protein Drugs
Biomaterials, (2015)
DOI: DOI:10.1016/j.biomaterials.2015.06.008.
(IF: 8.557) article

NEW! Synthesis and Bioactivity of a Conjugate Composed of Green Tea Catechins and Hyaluronic Acid
Polymer Chemistry, 6 (2015) 4462-4472.
(IF: 5.368) article

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