A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

ISO Certified (ISO 9001:2008)

OHSAS Certified (SS 506 Part 1:2009/ BS OHSAS 18001:2007

RESEARCH AREAS > Research Staff Details



Group Leader

Tel: 6824 7106
Email: yyyang@ibn.a-star.edu.sg

View CV

Adjunct Associate Professor, Department of Pharmacy, National University of Singapore, 2008-present
Visiting Scientist/Research Fellow/Senior Research Fellow, Institute of Materials Research & Engineering (Singapore), 1998-2003
Assistant/Associate Professor, 1990-1998

Ph.D. in Chemical Engineering, Tsinghua University (China), 1990
B.E. in Chemical Engineering, Hefei University of Technology (China), 1985

Projects Publications Patents


1. Polymeric Nanoparticles for Targeted Drug Delivery towards Cancer Cells and Cancer Stem Cells

Jeremy Tan, Xiyu Ke, Jye Yng Teo, Eunice Leong, Pei Yun Teo, Ashlynn Lee, Martin Nurmik, Shaoqiong Liu, Chuan Yang, Shrinivas Venkataraman, Nor Lizawati Ibrahim, Shujun Gao and Yi Yan Yang

We aim to develop safe polymer-based nanocarriers with narrow size distribution, high drug loading capacity and in vivo stability to transport small molecular anti-cancer drugs to cancer cells and cancer stem cells that are responsible for tumor relapse and metastasis. Biodegradable polymer nanoparticles that can interact with the drugs have been synthesized. A number of platform technologies have been developed to deliver a variety of drugs, proteins and genes. These co-delivery nanosized formulations have the potential to improve cancer therapy, prevent relapse and metastasis.

2. Macromolecular Antimicrobials to Combat Microbes

Chuan Yang, Wei Cheng, Noel Xu, Xin Ding, Shaoqiong Liu, Ashlynn Lee, Majad Khan, Shrinivas Venkataraman, Jeremy Tan, Nor Lizawati Ibrahim, Willy Chin, David Voo, Shujun Gao, Yuan Yuan, Hong Wu, Jackie Y. Ying, Yugen Zhang and Yi Yan Yang

The increasing prevalence of antibiotic resistant infections, such as Methicillin-resistant Staphylococcus aureus (MRSA), has sparked off a pressing need for innovative antimicrobial treatments. IBN has developed a new class of antimicrobial polymers and peptides that can provide a new arsenal against superbugs. Most modern-day antibiotics act on specific molecular targets within the bacteria. While this yields therapeutic specificity, it also allows resistance development through mutation since the bacterial cell structure is generally preserved. The antimicrobial macromolecules are biodegradable, biocompatible and have broad-spectrum antimicrobial activities against bacteria, yeast and fungi, to destroy multidrug-resistant microbes and prevent drug resistance development.


19 Jun
IBN Seminar Series: Elucidating the Involvement of Senescent Cells to Age-Related Pathologies by Prof. Darren J. Baker, Mayo Clinic, USA

18 Sep
Falling Walls Lab Singapore 2017

6 Dec - 10 Dec
5th Nano Today Conference

Event Calendar   


A Foldamer-Based Organocatalyst for Direct Arylations of Unactivated Arenes
Organic Letters, 19[8] (2017) 2190-2193.
(IF: 6.732) article

Biodegradable Cationic Poly(carbonates): Effect of Varying Side Chain Hydrophobicity on Key Aspects of Gene Transfection
Acta Biomaterialia, (2017)
DOI: 10.1016/j.actbio.2017.03.027.
(IF: 6.025) article

Short Synthetic β-Sheet Antimicrobial Peptides for the Treatment of Multidrug-Resistant Pseudomonas Aeruginosa Burn Wound Infections
Advanced Healthcare Materials, 6 (2017) 1601134.
(IF: 5.760) article



Research Positions

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