Nano Today Conference

A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

RESEARCH AREAS > Research Staff Details

Nanomedicine

   

YANG Yi Yan
Group Leader

Tel: 6824 7106
Email: yyyang@ibn.a-star.edu.sg

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Adjunct Associate Professor, Department of Pharmacy, National University of Singapore, 2008-present
Visiting Scientist/Research Fellow/Senior Research Fellow, Institute of Materials Research & Engineering (Singapore), 1998-2003
Assistant/Associate Professor, 1990-1998

Ph.D. in Chemical Engineering, Tsinghua University (China), 1990
B.E. in Chemical Engineering, Hefei University of Technology (China), 1985

Projects Publications Patents

Nanomedicine

1. Polymeric Nanoparticles for Targeted Drug Delivery towards Cancer Cells and Cancer Stem Cells

Shaoqiong Liu, Ashlynn Lee, Chuan Yang, Nor Lizawati Ibrahim, Shujun Gao and Yi Yan Yang

We aim to develop safe polymer-based nanocarriers with narrow size distribution, high drug loading capacity and in vivo stability to transport small molecular anti-cancer drugs to cancer cells and cancer stem cells that are responsible for tumor relapse and metastasis. Biodegradable polymer nanoparticles that can interact with the drugs have been synthesized. A number of platform technologies have been developed to deliver a variety of drugs, proteins and genes. In particular, the co-delivery of dual drugs has been demonstrated to effectively suppress tumor growth by eliminating both cancer cells and cancer stem cells. These co-delivery nanosized formulations have the potential to improve cancer therapy, and prevent relapse and metastasis.

2. Macromolecular Antimicrobials to Combat Microbes

Chuan Yang, Shrinivas Venkataraman, Xin Ding, Shaoqiong Liu, Jeremy Tan, David Voo, Zhen Chang Liang, Eddy Tan, Shujun Gao, Yuan Yuan, Diane Lim, Hong Wu, Jackie Y. Ying, Yugen Zhang and Yi Yan Yang

The increasing prevalence of antibiotic-resistant infections, such as Methicillin-resistant Staphylococcus aureus (MRSA), has sparked off a pressing need for innovative antimicrobial treatments. IBN has developed a new class of antimicrobial polymers and peptides that can provide a new arsenal against superbugs. Most modern-day antibiotics act on specific molecular targets within the bacteria. While this yields therapeutic specificity, it also allows resistance development through mutation since the bacterial cell structure is generally preserved. The antimicrobial macromolecules are biodegradable and biocompatible, and have broad-spectrum antimicrobial activities against bacteria, yeast and fungi, to destroy multidrug-resistant microbes and prevent drug resistance development.

3. Antiviral Polymers with Broad-Spectrum Activity, High Selectivity and Resistance Mitigation

Chuan Yang, Shujun Gao and Yi Yan Yang

Treatment of viral infections continues to be challenging due to the variance in viral structure (RNA, DNA, enveloped and non-enveloped viruses) and their ability to rapidly mutate and garner resistance. We have developed a general strategy to prevent viral infection using multi-functional macromolecules that were designed to have mannose moieties that compete with viruses for immune cells, and basic amine groups that block viral entry through electrostatic interactions and prevent viral replication by neutralizing the endosomal pH. These macromolecules effectively prevented dengue, influenza, Chikungunya, Enterovirus 71, Ebola, Marburg and herpes simplex infections at polymer concentrations as low as 0.2 mg/L with very high selectivity (> 5000) over mammalian cells. As the antiviral mechanism is based on non-specific supramolecular interactions between the amino acid residues and mannose/cationic moieties of the macromolecule, repeated use of the molecules did not induce drug resistance development. These macromolecules are being tested for in vivo efficacy.

EVENTS

2017
6 Dec - 10 Dec
5th Nano Today Conference

Event Calendar   

FEATURED PUBLICATIONS

NEW! Generation of ‘‘Off-the-Shelf’’ Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells
Stem Cell Reports, (2017)
DOI: https://doi.org/10.1016/j.stemcr.2017.10.020.
(IF: 7.338) article

NEW! Aptamer-Based ELISA Assay for Highly Specific and Sensitive Detection of Zika NS1 Protein
Analytical Chemistry, (2017)
DOI: 10.1021/acs.analchem.7b02862.
(IF: 6.320) article

Genetic Alphabet Expansion Transcription Generating Functional RNA Molecules Containing a Five-Letter Alphabet Including Modified Unnatural and Natural Base Nucleotides by Thermostable T7 RNA Polymerase Variants
Chemcial Communications, (2017)
DOI: 10.1039/c7cc06661a.
(IF: 6.319) article

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