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RESEARCH AREAS > Research Staff Details

Synthetic Biosystems/Biodevices and Diagnostics

   

SUN William
Team Leader and Principal Research Scientist

Tel: 6824 7111
Email: wsun@ibn.a-star.edu.sg

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Group Leader, Experimental Therapeutics Centre (Singapore) 2007-2013
Project Manager, ES Cell International Pte Ltd (Singapore) 2002-2007
Senior Research Scientist, Metabasis Therapeutics, Inc. (USA) 1997-2009

PhD, Biology Department, UC San Diego 1994
BS, Biology Department, MIT 1988

Projects Publications

Biodevices and Diagnostics

1. Antibody Engineering for Rapid Diagnostic Tests

Thai Leong Yap, Huajing Wang, Shin Yee Hong, Ying Ping Chua and William Sun

Rapid tests for the detection of infectious diseases can provide diagnosis at the point-of-care setting, enabling speedy and proper patient management. Rapid diagnostics, such as the lateral flow strip, require high-quality antibodies. We use a variety of engineering methods to isolate antibodies specific for pathogen proteins. These antibodies can then be incorporated into suitable assay platforms for the development of diagnostic tests. Our efforts are focused on generating rapid tests for diagnosing infections prevalent in Southeast Asia, such as dengue fever and Zika.

2. Paper-Based Assays

Jun Hui Soh, Benjamin Tai, Thai Leong Yap, Aysha Farwin, Min Hu, Huajing Wang, Shin Yee Hong, Ying Ping Chua, Kyun Hyun Lee, Huaqiang Zeng, William Sun and Jackie Y. Ying

IBN is developing diagnostic platforms for infectious diseases that can be translated into point-of-care rapid test kits. The new paper-based assays can detect diseases such as dengue, Zika, hepatitis, and sexually transmitted diseases, using a small volume of blood or non-invasive saliva and urine samples. They are designed to be fast, accurate and convenient for self-testing so as to facilitate health monitoring. We are incorporating new reagents, such as aptamers, short peptides, and new antibodies to further improve the assay’s performance. Paper-based assays are also being developed for food safety and environment monitoring applications, as well as to monitor cellular metabolic activities.

EVENTS

2017
6 Dec - 10 Dec
5th Nano Today Conference

Event Calendar   

One-North Run 2017

FEATURED PUBLICATIONS

Combinatorial Evolution of Fast-Conducting Highly Selective K+- Channels via Modularly Tunable Directional Assembly of Crown Ethers
Journal of the American Chemical Society, (2017)
DOI: 10.1021/jacs.7b04335.
(IF: 13.858) article

Molecular Characterization of Circulating Colorectal Tumor Cells Defines Genetic Signatures for Individualized Cancer Care
Oncotarget, (2017)
DOI: 10.18632/oncotarget.19138.
(IF: 5.168) article

Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts
Molecular Cancer Therapeutics, (2017)
DOI: 10.1158/1535-7163.MCT-16-0793.
(IF: 5.764) article

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