The following are research publications published by IBN in FY2011:

Drug and Gene Delivery

1. N. Wiradharma, S. Q. Liu and Y. Y. Yang, "Branched and Star-Like Alpha-Helical Peptide Structures with Enhanced Antimicrobial Potency and Selectivity," Small, (2011) DOI: 10.1002/smll.201101672
   
   
2. A. L. Z. Lee, S. Venkataraman, S. B. M. Sirata, S. Gao, J. L. Hedrick and Y. Y. Yang, "The Use of Cholesterol-Containing Biodegradable Block Copolymers to Exploit Hydrophobic Interactions for the Delivery of Anticancer Drugs," Biomaterials, 33 (2011) 1921-1928
   
   
3. C. Wu and S. Wang, "A pH-Sensitive Heparin-Binding Sequence from Baculovirus gp64 Protein Is Important for Binding to Mammalian Cells but Not to fSf9 Insect Cells," Journal of Virology, 86 (2011) 484
   
   
4. Y. Qiao, C. Yang, D. J. Coady, Z. Y. Ong, J. L. Hedrick and Y. Y. Yang, "Highly Dynamic Biodegradable Micelles Capable of Lysing Gram-Positive and Gram-Negative Bacterial Membrane," Biomaterials, 33 (2011) 1146-1153
   
   
5. L. S. Wang, J. E. Chung and M. Kurisawa, "Controlling Fibroblast Proliferation with Dimensionality-Specific Response by Stiffness of Injectable Gelatin Hydrogels," Journal of Biomaterials Science (Polymer Edition), (2011) DOI: 10.1163/156856211x598193
   
   
6. C. Yang, Z. Y. Ong, Y. Y. Yang, P. L. Ee and J .L. Hedrick, "Novel Biodegradable Block Copolymers of Poly(ethylene glycol) (PEG) and Cationic Polycarbonate: Effects of PEG Configuration on Gene Delivery," Macromolecular Rapid Communications, 32 (2011) 1826-1833
   
   
7. D. J. Coady, A. C. Englerand Y. Y. Yang and J. L. Hedrick, "Facile Routes to Star Polymers via an Organocatalytic Approach," Polymer Chemistry, 2 (2011) 2619-2626
   
   
8. N. Wiradharma, M. Khan, L-K. Yong, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang, "The Effect of Thiol Functional Group Incorporation into Cationic Helical Peptides on Antimicrobial Activities and Spectra," Biomaterials, 32 (2011) 9100-9108
   
   
9. E.X. Lee, D. H Lam, C. Wu, J. Yang, C. K. Tham, W. H. Ng and S. Wang, "Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells," Molecular Pharmaceutics, 8 (2011) 1515-1524
   
   
10. S. Venkataraman, J. L. Hedrick, Z. Y. Ong, C. Yang, P. L. R. Ee, P. T. Hammond and Y. Y. Yang, "The Effects of Polymeric Nanostructure Shape on Drug Delivery," Advanced Drug Delivery Reviews, 63 (2011) 1228-1246
    
    
11. S.L. Lo, Y. Choudhury and S. Wang, "Peptide-Based Nanomaterials for siRNA Delivery: Design, Evaluation and Challenges," Nanobiomaterials Handbook, (2011) DOI: 10.1201/b10970-10
    
    
12. C. J. A. Ramachandra, M. Shahbazi, T. W. X. Kwang, Y. Choudhury, X. Y. Bak, J. Yang and S. Wang, "Efficient Recombinase-Mediated Cassette Exchange at the AAVS1 Locus in Human Embryonic Stem Cells Using Baculoviral Vectors," Nucleic Acids Research, 39 (2011) e107
    
    
13. Y. Zhao, D. H. Lam, J. Yang, C. K. Tham, W. H. Ng and S. Wang, "Targeted Suicide Gene Therapy for Glioma Using Human Embryonic Stem Cell-Derived Neural Stem Cells Genetically Modified by Baculorviral Vectors," Gene Therapy, (2011) DOI: 10.1038/gt.2011.82
    
    
14. S. H. Kim, J. P.K. Tan, K. Fukushima, F. Nederberg, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick, "Thermoresponsive Nanostructured Polycarbonate Block Copolymers as Biodegradable Therapeutic Delivery Carriers," Biomaterials, 32 (2011) 5505-5514
    
    
15. M. Sugai, K. Aoki, M. Osato, Y. Nambu, K. Ito, M. M. Taketo and A. Shimizu, "Runx3 is Required for Full Activation of Regulatory T Cells to Prevent Colitis-Associated Tumor Formation," The Journal of Immunology, (2011) DOI: 10.4049/?jimmunol.1001671
    
    
16. T. Yokomizo, C. E. L. Ng, M. Osato and E. Dzierdzak, "Three-Dimensional Imaging of Whole Midgestation Murine Embryos Shows an Intravascular Localization for All Hematopoeitic Clusters," Blood, 117 (2011) 6132-6134
    
    
17. F. Nederberg, Y. Zhang, J. P. K. Tan, K. Xu, H. Wang, C. Yang, S. Gao, X. D. Guo, K. Fukushima, L. Li, J. L. Hedrick and Y. Y. Yang, "Biodegradable Nanostructures with Selective Lysis of Microbial Membranes," Nature Chemistry, 3 (2011) 409-414
    
    

Cell and Tissue Engineering

1. A. Lakshmanan, S. Zhang and C. A. E. Hauser, "Short Self-Assembling Peptides as Building Blocks for Modern Nanodevices," Trends in Biotechnology, (2011) DOI: 10.1016/j.tibtech.2011.11.001
   
   
2. H. F. Lu, K. Narayanan, S-X Lim, S. Gao, M. F. Leong and A. C. A. Wan, "A 3D Microfibrous Scaffold for Long-Term Human Pluripotent Stem Cell Self-Renewal Under Chemically Defined Conditions," Biomaterials, (2011) DOI: 10.1016/j.biomaterials.2011.11.077
   
   
3. E. C. Wu, S. Zhang and C. A. E. Hauser, "Self-Assembling Peptides as Cell-Interactive Scaffolds," Advanced Functional Materials, (2011) DOI: 10.1002/adfm.201101905
   
   
4. L. Xia, R. B. Sakban, Y.Qu, X. Hong, W. Zhang, B. Nugraha, W. H. Tong, A. Ananthanarayanan, B. Zheng, I. Y-Y Chau, R. Jia, M. McMillian, J. Silva, S. Dallas and H. Yu, "Tethered Spheroids as an In Vitro Hepatocyte Model for Drug Safety Screening," Biomaterials, (2011) DOI: 10.1016/j.biomaterials.2011.12.006
   
   
5. A. C. A. Wan, M. F. Leong, J. K. C. Toh, Y. Zheng and J. Y. Ying, "Multicomponent Fibers by Multi-Interfacial Polyelectrolyte Complexation," Advanced Healthcare Materials, (2011) DOI: 10.1002/adhm.201100020
   
   
6. D. Choudhury, D. v. Noort, C. Iliescu, B. Zheng, K-L. Poon, S. Korzh, V. Korzh and H. Yu, "Fish and Chips: A Microfluidic Perfusion Platform For Monitoring Zebrafish Development," Lab on a Chip, (2011) DOI: 10.1039/c1lc20351g
   
   
7. T. M. Hsieh, A. C. A. Wan and J. Y. Ying, "Applications of Fabricated Micro- and Nanostructures in Biomedicine," MRS Bulletin, 36 (2011) 990-997
   
   
8. J Lin, F. Lu, W. Zheng, S. Xu, D. Tai, H. Yu and Z. Huang, "Assessment of Liver Steatosis and Fibrosis in Rats Using Integrated Coherent Anti-Stokes Raman Scattering and Multiphoton Imaging Technique," Journal of Biomedical Optics, 16 (2011) 116024
   
   
9. R. Magalhães, B. Nugraha, S. Pervaiz, H. Yu and L. L. Kuleshova, "Influence of Cell Culture Configuration on the Post-Cryopreservation Viability of Primary Rat Hepatocytes," Biomaterials, 33 (2011) 829-836
   
   
10. B. Zheng, L. Tan, X. Mo, W. Yu, Y. Wang, L.Tucker-Kellogg, R. E. Welsch, P. T. C. So and H. Yu, "Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis," PLoS ONE, 6 (2011) e26230
    
    
11. Y. C. Toh, K. Blagovic, H. Yu and J. Voldman, "Spatially Organized In Vitro Models Instruct Asymmetric Stem Cell Differentiation," Integrative Biology, 3 (2011) 1179-1187
    
    
12. F. Zhuang, K. Oglecka and C. A. E. Hauser, "Self-Assembling Peptide Surfactants A6K and A6D Adopt α-Helical Structures Useful for Membrane Protein Stabilization," Membranes, 1 (2011) 314-326
    
    
13. M. Ni, P. K. Zimmermann, K. Kandasamy, W. Lai, Y. Li, M. F. Leong, A. C. A. Wan and D. Zink, "The Use of a Library of Industrial Materials to Determine the Nature of Substrate-Dependent Performance of Primary Adherent Human Cells," Biomaterials, 33 (2011) 353-364
    
    
14. Y. Loo, S. Zhang and C. A. E. Hauser, "From Short Peptides to Nanofibers to Macromolecular Assemblies in Biomedicine," Biotechnology Advances, (2011) DOI: 10.1016/j.biotechadv.2011.10.004
    
    
15. L. Venkatraman, H. Li, C. F. Dewey, J. K. White, S. S. Bhowmick, H. Yu and L. Tucker-Kellogg, "Steady States and Dynamics of Uurokinase-Mediated Plasmin Activation In Silico and In Vitro," Biophysical Journal, 101 (2011) 1825-1834
    
    
16. A. Lakshmanan and C. A. E. Hauser, "Ultrasmall Peptides Self-Assemble into Diverse Nanostructures: Morphological Evaluation and Potential Implications," International Journal of Molecular Sciences, 12 (2011) 5736-5746
    
    
17. Y. O. Zay, R. Deng, M. Hu, M. Ni, K. Kandasamy, M. S. bin Ibrahim, J. Y. Ying and D. Zink, "The Performance of Primary Human Renal Cells in Hollow Fiber Bioreactors for Bioartificial Kidneys," Biomaterials, 32 (2011) 8806-8815
    
    
18. F. Tasnim, K. Kandasamy, J. S. Muck, M. S. bin Ibrahim, J. Y. Ying and D. Zink, "Effects of BMPs on Primary Human Renal Cells and the Generation of BMP-7-Expressing Cells for Applications in Bioartificial Kidneys," Tissue Engineering, Part A (2011)
    
    
19. S. L. J. Ng, K. Narayanan, S. Gao and A. C. A. Wan, "Lineage Restricted Progenitors for the Repopulation of Decellularized Heart," Biomaterials, 32 (2011) 7571-7580
    
    
20. E. Tamariz, A. C. A. Wan, Y. S. Pek, M. Giordano, G. Hernández-Padrón, A. Varela-Echavarría, I. Velasco and V. M. Castaño, "Delivery of Chemotropic Proteins and Improvement of Dopaminergic Neuron Outgrowth Through a Thixotropic Hybrid Nano-Gel," Journal of Materials Science: Materials in Medicine, 22 (2011) 2097-2109
    
    
21. B. Nugraha, X. Hong, X. Mo, L. Tan, W. Zhang, P-M. Chan, C. H. Kang, Y. Wang, L. T. Beng, W. Sun, D. Choudhury, J. M. Robens, M. McMillian, J. Silva, S. Dallas, C-H. Tan, Z. Yue and H. Yu, "Galactosylated Cellulosic Sponge for Multi-Well Drug Safety Testing," Biomaterials, 32 (2011) 6982-6994
    
    
22. Y. S. Pek and A. C. A. Wan, "Characterization of Early Extracellular Matrix Secretions in a Three-Dimensional Thixotropic Cell Culture System," Acta Biomaterialia, 7 (2011) 3981-3987
    
    
23. D. Choudhury, X. Mo, C. Iliescu, L. L. Tan, W. H. Tong and H. Yu, "Exploitation of Physical and Chemical Constraints for Three-Dimensional Microtissue Construction in Microfluidics," Biomicrofluidics, 5 (2011) 22203
    
    
24. A. Mishra, Y. Loo, R. Deng, Y. J. Chuah, H. T. Hee, J. Y. Ying and C. A. E Hauser, "Ultrasmall Natural Peptides Self-Assemble to Strong Temperature-Resistant Helical Fibers in Scaffolds Suitable for Tissue Engineering," Nano Today, 6 (2011) 232-239
    
    
25. Y. Li, Y. Zheng, K. Zhang, J. Y. Ying and D. Zink, "Effects of Quantum Dots on Different Renal Proximal Tubule Cell Models and on Gel-Free Renal Tubules Generated In Vitro," Nanotoxicology, (2011) DOI: 10.3109/17435390.2011.562326
    
    
26. J. ZHou, C. Bi, W.-J. Chng, L.-L. Cheong, S.-C. Liu, S. Mahara, K.-G. Tay, Q. Zeng, J. Li, K. Guo, C. P. B. Tan, H. Yu, D. H. Albert and C.-S. Chen, "PRL-3, A Metastasis Associated Tyrosine Phosphatase, is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy," PLoS ONE, 6 (2011) e19798
    
    
27. B. Jakob, J, Splinter, S. Conrad, K.-O. Voss, D. Zink, M. Durante, M. Loebrich and G. Taucher-Scholz, "DNA Double-Strand Breaks in Heterochromatin Elicit Fast Repair Protein Recruitment, Histone H2AX Phosphorylation and Relocation to Euchromatin," Nucleic Acids Research, 39 (2011) 6489-6499
    
    

Biodevices and Diagnostics

1. D. Y. Heng, M. MacKenzie, U. Vaishampayan, J. J. Knox, G. A. Bjarnason, M. H. Tan, L. Wood, F. Donskov, C. Kollmannsberger, S. North, F. Donskov0, B. I. Rini and T. K. Choueiri, "Primary Anti-Vascular Endothelial Growth Factor (VEGF)-Refractory Metastatic Renal Cell Carcinoma: Cinical Characteristics, Risk Factors and Subsequent Therapy," The Annals of Oncology, (2011) DOI: 10.1093/annonc/mdr533
   
   
2. P. H. Tan, A. A. Thike, W. J. Tan, M. M. Thu, I. Busmanis, H. Li, W. Y. Chay and M. H. Tan, "Predicting Clinical Behavior of Breast Phyllodes Tumors: A Nomogram Based on Histological Criteria and Surgical Margins," Journal of Clinical Pathology, 65 (2011) 69-76
   
   
3. G. Xu, D. Y. S. Lee, H. Xie, D. Chiew, T.-M. Hsieh, E. Mohamed Ali, X. L. Looi, M.-H. Li and J. Y. Ying, "A Self-Contained Polymeric Cartridge for Automated Biological Sample Preparation," Biomicrofluidics, 5 (2011) 34107
   
   
4. J. Zhang, M. C. Pearce, B. P. Ting and J. Y. Ying, "Ultrasensitive Electrochemical Immunosensor Employing Glucose Oxidase Catalyzed Deposition of Gold Nanoparticles for Signal Amplification," Biosensors and Bioelectronics, 27 [1] (2011) 53-57
   
   
5. H. Taylor, D. Boning and C. Iliescu, "A Razor-Blade Test of the Demolding Energy in a Thermoplastic Embossing Process," Journal of Micromechanics and Microengineering, 21 (2011) 67002
   
   
6. S.-C. Luo, S.S. Liour and H.-H. Yu, "Perfluoro-Functionalized PEDOT Films with Controlled Morphology as Superhydrophobic Coatings and Biointerfaces with Enhanced Cell Adhesion," Chemical Communications, 46 (2011) 4731-4733
   
   
7. G. Yi, Y. F. Peng and Z. Gao, "Strong Red-Emitting Near-Infrared-to-Visible Upconversion Fluorescent Nanoparticles," Chemistry of Materials, 23 (2011) 2729-2734
   
   
8. Y. Zu, A. L. Ting, G. Yi and Z. Gao, "Sequence-Selective Recognition of Nucleic Acids Under Extremely Low Salt Conditions Using Nanoparticle Probes," Analytical Chemistry, 83 (2011) 4090-4094
   
   
9. S. Roy, J. H. Soh and Z. Gao, "A Microfluidic-Assisted Microarray for Ultrasensitive Detection of miRNA Under an Optical Microscope," Lab on a Chip, 11 (2011) 1886-1894
   
   

Pharmaceuticals Synthesis and Green Chemistry

1. Y. Zhang and S. N. Riduan, "Functional Porous Organic Polymers for Heterogeneous Catalysis," Chemical Society Reviews, (2011) DOI: 10.1039/c1cs15227k
   
   
2. L. L. Chng, J. Zhang, J. Yang, M. Amoura and J. Y. Ying, "C-C Bond Formation via C-H Activation and C-N Bond Formation via Oxidative Amination Catalyzed by Palladium-Polyoxometalate Nanomaterials Using Dioxygen as the Terminal Oxidant," Advanced Synthesis and Catalysis, 353 (2011) 2988-2998
   
   
3. L. Lai and Y. Zhang, "The Production of 5-Hydroxymethyl-furfural from Fructose in iso-Propanol, A Green and Efficient System," ChemSusChem, 4 (2011) 1745-1748
   
   
4. J. Zhang, B. P. Ting, Y. T. Koh and J. Y. Ying, "Synthesis of Metallic Nanoparticles Using Electrogenerated Reduced Forms of [α-SiW12O40]^4- as Both Reductants and Stabilizing Agents," Chemistry of Materials, 23 (2011) 4688-4693
   
   
5. S. W. Millward, R. K. Henning, G. A. Kwong, S. Pitram, H. D. Agnew, K. M. Deyle, A. Nag, J. Hein, S. S. Lee, J. Lim, J. A. Pfeilsticker, K. B. Sharpless and J. R. Health, "Iterative In Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1," Journal of the American Chemical Society, 133 (2011) 18280-18288
   
   
6. N. Erathodiyil, H. Gu, H. Shao, J. Jiang and J. Y. Ying, "Enantioselective Hydrogenation of α-Ketoesters Over Alkaloid-Modified Platinum Nanowires," Green Chemistry, 13 (2011) 3070-3074
   
   
7. Z. Lin, D. Yu and Y. Zhang, "Propargylic Amines Constructed via Copper-Catalyzed Three Component-Coupling of Terminal Alkyne, Benzal Halide and Amine," Tetrahedron Letters, 52 [38] (2011) 4967-4970
   
   
8. Q. Kang and Y. Zhang, "N-Heterocyclic Carbene-Catalyzed Aza-Michael Addition," Organic and Biomolecular Chemistry, 9 (2011) 6715-6720
   
   
9. Y. Zhang and S. N. Riduan, "Catalytic Hydrocarboxylation of Alkenes and Alkynes with CO₂," Angewandte Chemie International Edition, 50 (2011) 6210-6212
   
   
10. N. Erathodiyil and J. Y. Ying, "Functionalization of Inorganic Nanoparticles for Bioimaging Applications," Accounts of Chemical Research, 44 (2011) 925-935
    
    
11. Y. Zhang, M. X. Tan, H. Li, Y. Zheng, H. Zhang and J. Y. Ying, "Mesoscopic Organic Nanosheets Peeled from Stacked 2D Covalent Frameworks," Chemical Communications, 47 (2011) 7365-7367
    
    
12. A. W. H. Lin, C. Y. Ang, P. K. Patra, Y. Han, H. Gu, J.-M. Le Breton, J. Juraszek, H. Chiron, G. C. Papaefthymiou, S. T. Selvan and J. Y. Ying, "Seed-Mediated Synthesis, Properties and Application of &lamda;-Fe₂O₃-CdSe Magnetic Quantum Dots," Journal of Solid State Chemistry, 184 [8] (2011) 2150-2158
    
    
13. J. Yang, X. Chen, F. Ye, C. Wang, Y. Zheng and J. Yang, "Core-Shell CdSe@Pt Nanocomposites with Superior Electrocatalytic Activity Enhanced by Lateral Strain Effect," Journal of Materials Chemistry, 21 (2011) 9088-9094
    
    
14. Y. Zhang, L. Chen and T. Lu, "A Copper(II) Triflate-Catalyzed Tandem Friedel-Crafts Alkylation/Cyclization Process Towards Dihydroindenes," Advanced Synthesis and Catalysis, 353 (2011) 1055-1060
    
    
15. Y. Li, Y. Lu, H. Hong, Y. Chen, X. Ma, L. Guo, Z. Wang, J. Chen, M. Zhu, J. Ni, H. Gu, J. Lu and J. Y. Ying, "Synthesis of Pt@Fe₂O₃ Nanorods as MRI Probes for In Vivo Application," Chemical Communications, 47 (2011) 6320-6322
    
    
16. J. Yang and J. Y. Ying, "Nanocomposites of Ag₂S and Noble Metals," Angewandte Chemie International Edition, 50 (2011) 4637-4643
    
    
17. J. Mao, X. Cao, J. Zhen, H. Shao, H. Gu, J. Lu and J. Y. Ying, "Facile Synthesis of Hybrid Nanostructures from Nanoparticles, Nanorods and Nanowires," Journal of Materials Chemistry, 21 (2011) 11478-11481
    
    

The Use of a Library of Industrial Materials to Determine the Nature of Substrate-Dependent Performance of Primary Adherent Human Cells
Biomaterials, (2011)
DOI:10.1016/j.biomaterials.2011.09.063

From Short Peptides to Nanofibers to Macromolecular Assemblies in Biomedicine
Biotechnology Advances, (2011)
DOI:10.1016/j.biotechadv.2011.10.004.

The Production of 5-Hydroxymethylfurfural from Fructose in Isopropyl Alcohol: A Green and Efficient System
ChemSusChem, (2011)
DOI:10.1002/cssc.201100489

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