A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

RESEARCH AREAS > Synthetic Biosystems

Synthetic Biosystems

Synthetic Biosystems, where biomimetic materials, innovative cell culture, 3D printing technologies, microfluidic systems and bioimaging are combined to develop novel approaches for regenerative medicine, in vitro compound screening, and disease modeling.

View research projects, research publications and research staff in this research area.

Research Projects

1. Anti-Fouling Polymer Hydrogels for Biomedical Applications

Nandanan Erathodiyil, Hong Wu, Yiran Zheng and Jackie Y. Ying

The success of implantable biomedical device technologies depends on controlling bio-interfacial phenomena, such as foreign body response and implant encapsulation. Thus, precise control of interactions between host material surfaces and the physiological environment is critical for effective and safe application of medical devices and biosensors. Immobilization and coating of anti-fouling polymers on implantable surfaces have been used to reduce the interaction of the designed surfaces with biomolecules, cells, bacteria and microorganisms. Our research is focused on the development of cost-effective, versatile and facile synthesis of anti-fouling biomaterials. Novel nanostructured hydrogel materials of various compositions, architecture and surface chemistry are created with excellent anti-fouling performance and long-term durability under in vivo conditions. We are also designing anti-coagulant and omniphobic materials with chemical and structural versatility, which would aid in achieving the full potential of these materials for biomedical applications.

2. Biomaterials for Cell Reprogramming

Hongfang Lu, Jia Kai Lim and Andrew Wan

Cell plasticity refers to the ability of cells to be reprogrammed to other cell types, including stem cells. Our research efforts are focused on two fronts. First, we are trying to replace the more conventional cell reprogramming method, which typically involves genetic modification of cells, with transgene-free and xeno-free methods that dispense with the use of animal products. Through this, we hope to develop a safer source of cells for use in regenerative medicine. Our second research focus is on investigating the role of the cellular microenvironment in the reprogramming of cancer cells. We have shown that the extracellular matrix and 3D environment combine to influence the stemness of glioma cells, which is typically associated with the cells’ self-renewal and drug-resistance properties. This information would be useful in developing new cancer therapies.

3. Biomimetic Ultrashort Peptide Hydrogel Scaffolds for Tissue Engineering

Yihua Loo, Wei Yang Seow and Andrew Wan

IBN researchers have designed a unique class of ultrashort peptides of only 3 to 7 aliphatic amino acids that self-assemble into nanofibrous hydrogels in aqueous conditions. These hydrogels are attractive materials for tissue scaffolds, as their microarchitecture resembles extracellular matrix in the body. The hydrogels also possess mechanical strength that far exceeds that of soft tissue in the human body, but can be tuned to the desired strength, enabling the biofabrication of 3D organotypic constructs for disease modeling or implantation. Harnessing their propensity for self-assembly and taking advantage of their mechanical rigidity, these peptides are of interest as bioinks for 3D bioprinting, injectable scaffolds for regenerative medicine, synthetic 3D matrices for stem cell culture, and wound dressing for burn treatment.

4. Chemically Modified Glycomimetics as Molecular Scaffolds

Song-Gil Lee, Jerry Kah Chin Toh, Teck Chuan Lim, Ashwin Srinivasan Kumar and Su Seong Lee

Although carbohydrates mediate important biological processes in the human body, their structural complexity and diversity have hindered efforts to understand their defined biological roles. Synthetic access to carbohydrate molecules of defined structure, in combination with biological studies, could provide unique tools for a systematic examination of structure-activity relationships. We are interested in developing structurally well-defined carbohydrate mimetics via synthetic approaches. These synthetic carbohydrate mimetics would pave the way for the development of carbohydrate-based drugs, vaccines, adjuvants, as well as novel biomaterials.

5. Digital Livers: Quantitative Analysis of the Dynamic Processes of Liver Regeneration and Chronic Liver Diseases

Ziwei Song, Yu Yang and Hanry Yu

We have developed optical imaging modalities to quantify cellular and extracellular changes in tissues. The instruments and machine-learning based image-processing/feature analysis algorithms developed are used to automate and improve pathological examinations related to (i) liver fibrosis, (ii) cholestasis and (iii) non-alcoholic fatty liver diseases. This helps to shed light on the etiology of the diseases quantitatively. We have developed a high-throughput tissue imaging platform to quantify tissue/cell and matrix features of big blocks of tissue in mice or the entire biopsy sample at molecular and cellular resolutions for 3D characterization of disease progression. We have spun off an award-winning company, HistoIndex Pte Ltd, from this project, and licensed key technologies to another start-up company, InvitroCue Pte Ltd, to create an impact in the digital pathology and telemedicine landscape. The team is also investigating the fundamental process of liver regeneration by quantifying and modeling the mechanical and biochemical regulation of the cellular hypertrophy.

6. Drug Testing Platforms: Development of Robust, Inexpensive, Scalable and Predictive Assays for Safety Testing of Drugs and Chemicals

Farah Tasnim, Jiangwa Xing, Xiaozhong Huang and Hanry Yu

Cell-based assays for in vitro toxicity evaluation are attracting increasing attention from institutions and companies involved in the development of drugs and industrial chemicals. The major bottlenecks are the lack of stable human primary cells, and cell-culture models that recapitulate the in vivo physiological responses to the tested compounds. So far, only the sandwich culture of liver cells is accepted by the Federal Drug Administration (FDA) for routine hepatotoxicity testing of drugs. To improve the cell-based assays, we have developed (i) a scalable aligned substrate on optical media, (ii) two improved spheroid models for acute and chronic toxicity testing, respectively, (iii) a co-culture model for idiosyncratic toxicity, (iv) three perfusion-based models for improved sensitivity to detect metabolites, (v) a developmental toxin based on morphogenic migration of human stem cells, and (vi) stable and robust cell sources from human stem or progenitor cells. We are validating these established models for hepatotoxicity and teratogen testing of compounds, and improving the performance of these platforms for robustness, predictive fidelity, scalability and cost. We are also extending the applications of these models to sub-acute/chronic hepatotoxicity in order to better mimic “in vivo-like” conditions.

7. Engineering Complex Tissues: Spatial and Temporal Control of Microenvironment

Zheng Liu (Justinian), Farah Tasnim and Hanry Yu

Complex tissues with multiple cell types will be engineered by controlling cell-cell and cell-matrix interactions through (i) engineering inter-cellular linkers for 3D printing, (ii) engineering cellular response to the chemical and mechanical signals by developing ultra-soft macroporous sponges that are robust, transparent, degradable and enhancing compact spheroid formation, and (iii) fabricating relevant 3D microfluidics, micro-patterns and ultra-thin porous membranes incorporating mechanical compaction and multiple cell types for organ-on-a-chip applications, such as a liver cancer chip to aid chemotherapy testing. This project establishes the fundamental principles, toolboxes and devices to precision-engineer micro-tissue constructs of different cell types and inter-cellular tissue space (such as sinusoid and bile canaliculi in liver) for repeated dose testing of compounds that require mid-term (> 2-4 weeks) or long-term (up to 6 weeks) culture of micro-tissue constructs.

8. Fibrous Scaffolds for Tissue Engineering

Andrew Wan, Chan Du, Tze Chiun Lim, Hongfang Lu and Jackie Y. Ying

Tissue engineering requires the use of a framework or scaffold for cells to attach and grow. In addition, scaffolds may contain biological molecules, which control the rate of cell growth and propensity of stem cells to differentiate into cells of specific tissues and organs. Most of the current processes for the production of tissue scaffolds require high temperatures and organic solvents, which may denature the proteins and other biological molecules to be incorporated. In this project, we are fabricating scaffolds by encapsulating cells and the relevant biological molecules into fibers that are formed at the interface between two oppositely charged polyelectrolytes. These fibers are then combined to form 3D patterned tissue constructs.

9. New Alternative Methods for the Prediction of Chemical- and Nanomaterial-Induced Toxicities in Humans

Jacqueline Chuah, Yao Li, Faezah Hussain, Peng Huang, Kim Guan Eng and Daniele Zink

New alternative methods for toxicity prediction are required by the pharmaceutical, chemical, food and consumer care industries. Currently, there are no accepted alternative methods for the prediction of toxicities for human internal organs, such as the kidney and liver. We are developing robust screening platforms that predict toxicities to human internal organs with high sensitivity and accuracy (test balanced accuracy > 80%). Our methods include several novel technologies, such as the first in vitro assay that predicts nephrotoxicity in humans with high accuracy, the first stem cell-based predictive renal screening platforms, and the first predictive kidney-specific high-throughput platform. Our kidney-specific technologies have been awarded by the US Society of Toxicology (2015) and have won the Lush Prize (2016, Science category). The renal high-throughput platform is applied in collaboration with the US Environmental Protection Agency for the prediction of the human nephrotoxicity of ToxCast compounds. Our high-throughput technology is currently adapted for the prediction of other organ-specific toxicities. A liver-specific platform has been established, and a vasculature-specific platform is under development. Our methods can also be applied for the prediction of chemical- as well as nanomaterial-induced toxicities.

10. Synthetic Substrates for the Scalable Expansion of Human Pluripotent Stem Cells Under Chemically Defined Conditions

Nandanan Erathodiyil, Siv Ly Khou, Aysha Farwin, Yi Fei Lee, Yiran Zheng and Jackie Y. Ying

Clinical applications of human stem cells require large cell numbers and cell growth under chemically defined conditions. Appropriate in vitro culture systems should include synthetic substrates that support stem cell growth in combination with media that do not contain any components purified from humans or animals. Large-scale applications of expensive materials, such as peptide-based substrates, are cost-prohibitive. We are developing cost-effective and fully synthetic coatings and microcarriers for the scalable expansion of human embryonic, and induced pluripotent and mesenchymal stem cells. Under chemically defined conditions, different types of human pluripotent stem cells can be propagated for many passages without karyotypic changes, while maintaining their cell type-specific properties in terms of self-renewal, marker expression, and potency.

Research Publications

  1. Jieming Zeng, Shin Yi Tang, Lai Ling Toh and Shu Wang, "Generation of ‘‘Off-the-Shelf’’ Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells," Stem Cell Reports, (2017) DOI: https://doi.org/10.1016/j.stemcr.2017.10.020

  2. Z. Song, K. Gupta, I. C. Ng, J. Xing, Y. A. Yang and H. Yu, "Mechanosensing in Liver Regeneration," Seminars in Cell and Developmental Biology, (2017) DOI: 10.1016/j.semcdb.2017.07.041

  3. L. J. Y. Ong, L. H. Chong, L. Jin, P. K. Singh, P. S. Lee, H. Yu, A. Ananthanarayanan, H. L. Leo and Y.-C. Toh, "A Pump-Free Microfluidic 3D Perfusion Platform for the Efficient Differentiation of Human Hepatocyte-Like Cells," Bioengineering & Biotechnology, (2017) DOI: 10.1002/bit.26341

  4. Y. Choudhury, Y. C Toh, J. Xing, Y. Qu, J. Poh, L. Huan, H. S. Tan, R. Kanesvaran, H. Yu and M-H. Tan, "Patient-Specific Hepatocyte-Like Cells Derived from Induced Pluripotent Stem Cells Model Pazopanib-Mediated Hepatotoxicity," Scientific Reports, 7 (2017) 41238

  5. J. K. C. Chuah and D. Zink, "Stem Cell-Derived Kidney Cells and Organoids: Recent Breakthroughs and Emerging Applications," Biotechnology Advances, (2017) DOI: 10.1016/j.biotechadv.2016.12.001

  6. M. F. Leong, H. F. Lu, T. C. Lim, C. Du, N. K. L. Ma and A. C. A. Wan, "Electrospun Polystyrene Scaffolds as a Synthetic Substrate for Xeno-Free Expansion and Differentiation of Human Induced Pluripotent Stem Cells," Acta Biomaterialia, (2016) DOI: 10.1016/j.actbio.2016.09.032

  7. W. Y. Seow, G. Salgado, E. B. Lane and C. A. E. Hauser, "Transparent Crosslinked Ultrashort Peptide Hydrogel Dressing with High Shape-Fidelity Accelerates Healing of Full-Thickness Excision Wounds," Scientific Reports, 6 (2016) 32670

  8. C. Du, K. Narayanan, M. F. Leong, M. S. Ibrahim, Y. P. Chua, V. M. H. Khoo and A. C. A. Wan, "Functional Kidney Bioengineering with Pluripotent Stem-Cell-Derived Renal Progenitor Cells and Decellularized Kidney Scaffolds," Advanced Healthcare Materials, (2016) DOI: 10.1002/adhm.201600120

  9. G.Y. Chew, J.H.J. Tan, A.W. Bahta, B.S.-Y. Ho, X. Liu, T.C. Lim, Y.Y. Sia, P.L. Bigliardi, S. Heilmann, A.C.A. Wan, M.M. Nöthen, M.P. Philpott and Hillmer, "Differential Expression Between Human Dermal Papilla Cells from Balding and Nonbalding Scalps Reveals New Candidate Genes for Androgenetic Alopecia," Journal of Investigative Dermatology, (2016) DOI: 10.1016/j.jid.2016.03.032

  10. A. C. A. Wan, "Recapitulating Cell–Cell Interactions for Organoid Construction – Are Biomaterials Dispensable?," Trends in Biotechnology, (2016) DOI: 10.1016/j.tibtech.2016.02.015

  11. A. C. A. Wan, M. F. A. Cutiongco, B. C.U. Tai, M. F. Leong, H. F. Lu and E. K. F. Yim, "Fibers by Interfacial Polyelectrolyte Complexation – Processes, Materials and Applications," Materials Today, (2016) DOI: 10.1016/j.mattod.2016.01.017

  12. S. Dorfmueller, H. C. Tan, Z. X. Ngoh, K. Y. Toh, G. Peh, H. P. Ang, X. Y. Seah, A. Chin, A. Choo, J. S. Mehta and W. Sun, "Isolation of a Recombinant Antibody Specific for a Surface Marker of the Corneal Endothelium by Phage Display," Scientific Reports, (2016) DOI: 10.1038/srep21661

  13. Q. Li, Y. Zhang, P. Pluchon, J. Robens, K. Herr, M. Mercade, J-P. Thiery, H. Yu and V. Viasnoff, "Extracellular Matrix Scaffolding Guides Lumen Elongation by Inducing Anisotropic Intercellular Mechanical Tension," Nature Cell Biology, (2016) DOI: 10.1038/ncb3310

  14. K. Narayanan, N. Erathodiyil, B. Gopalan, S. Chong, A. C. A. Wan and J. Y. Ying, "Targeting Warburg Effect in Cancers with PEGylated Glucose," Advanced Healthcare Materials, (2016) DOI: 10.1002/adhm.201500613

  15. R. Su, S. Xiong, D. Zink and L.H. Loo, "High-Throughput Imaging-Based Nephrotoxicity Prediction for Xenobiotics with Diverse Chemical Structures," Archives of Toxicology, (2015) DOI: 10.1007/s00204-015-1638-y

  16. N. K. L. Ma, J. K. Lim, M. F. Leong, E. Sandanaraj, B. T. Ang, C. Tang and A. C. A. Wan, "Collaboration of 3D Context and Extracellular Matrix in the Development of Glioma Stemness in a 3D Model," Biomaterials, 78 (2016) 62–73

  17. Y. Loo, M. Goktas, A. B. Tekinay, M. O. Guler, C. A. E. Hauser and A. Mitraki, "Self-Assembled Proteins and Peptides as Scaffolds for Tissue Regeneration," Advanced Healthcare Materials, 4[16] (2015) 2557-2567

  18. L. Qiu, H. Yu and F. Liang, "Multiple C2 Domains Transmembrane Protein 1 is Expressed in CNS Neurons and Possibly Regulates Cellular Vesicle Retrieval and Oxidative Stress," Journal of Neurochemistry, (2015) DOI: 10.1111/jnc.13251

  19. F. Tasnim, D. Phan, Y. C. Toh and H. Yu, "Cost-Effective Differentiation of Hepatocyte-Like Cells from Human Pluripotent Stem Cells Using Small Molecules," Biomaterials, 70 (2015) 115-125

  20. K. Kandasamy, J. K. C. Chuah, R. Su, P. Huang, K. G. Eng, S. Xiong, Y. Li, C. S. Chia, L.-H. Loo and D. Zink, "Prediction of Drug-Induced Nephrotoxicity and Injury Mechanisms with Human Induced Pluripotent Stem Cell-Derived Cells and Machine Learning Methods," Scientific Reports, (2015) DOI: 10.1038/srep12337

  21. L. Xia, X. Hong, R. B. Sakban, Y. Qu, N. H. Singh, M. McMillian, S. Dallas, J. Silva, S. Zhao, H. K. Lim and H. Yu, "Cytochrome P450 Induction Response in Tethered Spheroids as a Three-Dimensional Human Hepatocyte In Vitro Model," Journal of Applied Toxicology, (2015) DOI: 10.1002/jat.3189

  22. S. Xu, C. H. Kang, X. Gou, Q. Peng, J. Yan, S. Zhuo, C. L. Cheng, Y. He, Y. Kang, W. Xia, P. T. C. So, R. Welsch, J. C. Rajakse and H. Yu, "Quantification of Liver Fibrosis via Second Harmonic Imaging of the Glisson's Capsule from Liver Surface," Journal of Biophotonics, (2015) DOI: 10.1002/jbio.201500001

  23. J. Xing, Y. C. Toh, S. Xu and H. Yu, "A Method for Human Teratogen Detection by Geometrically Confined Cell Differentiation and Migration," Scientific Reports, (2015) DOI: 10.1038/srep10038

  24. Y. C. Toh, J. Xing and H. Yu, "Modulation of Integrin and E-Cadherin-Mediated Adhesions to Spatially Control Heterogeneity in Human Pluripotent Stem Cell Differentiation," Biomaterials, 50 (2015) 87-97

  25. K. S. Chian, M. F. Leong and K. Kono, "Regenerative Medicine for Oesophageal Reconstruction after Cancer Treatment," The Lancet Oncology, 16[2] (2015) e84–92

  26. C. Ren, S. Gao, M. Kurisawa and J. Y. Ying, "Cartilage Synthesis in Hyaluronic Acid-Tyramine Constructs," Journal of Materials Chemistry B, 3 (2015) 1942-1956

  27. Z. Wang, X. Luo, C. Anene-Nzelu, Y. Yu, X. Hong, N. H. Singh, L. Xia, S. Liu and H. Yu, "HepaRG Culture in Tethered Spheroids as an In Vitro Three-Dimensional Model for Drug Safety Screening," Journal of Applied Toxicology, (2014) DOI: 10.1002/jat.3090

  28. R. Su, Y. Li, D. Zink and L.-H. Loo, "Supervised Prediction of Drug-Induced Nephrotoxicity Based on Interleukin-6 and -8 Expression Levels," BMC Bioinformatics, 15 (2014) S16

  29. A. Mehta, V. Verma, M. Nandihalli, C. J. A. Ramachandra, G. L. Sequiera, Y. Sudibyo, Y. Chung, W. Sun and W. Shim, "A Systemic Evaluation of Cardiac Differentiation from mRNA Reprogrammed Human Induced Pluripotent Stem Cells," PLoS ONE, 9 (2014) e114771

  30. J. Yan, Y. Kang, S. Xu, S. L. L. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. So, I. R. Wanless and H. Yu, "In Vivo Label-Free Quantification of Liver Microcirculation Using Dual Modality Microscopy," Journal of Biomedical Optics, 19 (2014) 11606

  31. N. Mittal and I. J. Domian, "Persistent Integration of Reprogramming Factors Impairs the In Vitro Cardiogenic Potential of Induced Pluripotent Stem Cells," Circulation Cardiovascular Genetics, 7 (2014) 571-572

  32. B. Gopalan, K. Narayanan, Z. Ke, T. Lu, Y. Zhang and L. Zhuo, "Therapeutic Effect of a Multi-Targeted Imidazolium Compound in Hepatocellular Carcinoma," Biomaterials, 35[26] (2014) 7479-7487

  33. J. W. Cha, V. R. Singh, K. H. Kim, J. Subramanian, Q. Peng, H. Yu, E. Nedivi, and P. T. C. So, "Reassignment of Scattered Emission Photons in Multifocal Multiphoton Microscopy," Scientific Reports, 4 (2014) 5153

  34. M. Reithofer, A. Lakshmanan, A. T. K. Ping, J. M. Chin, C. A. E. Hauser, "In Situ Synthesis of Size-Controlled, Stable Silver Nanoparticles Within Ultrashort Peptide Hydrogels and their Anti-Bacterial Properties," Biomaterials, 35[26] (2014) 7535-7542

  35. W. Y. Seow and C. A. E. Hauser, "Short to Ultrashort Peptide Hydrogels for Biomedical Uses," Materials Today, 17[8] (2014) 381–388

  36. A. Ananthanarayanan, B. Nugraha, M. Triyanti, S. Hart, S. Sankuratri and H. Yu, "Scalable Spheroid Model of Human Hepatocytes for Hepatitis C Infection and Replication," Molecular Pharmaceutics, 11[7] (2014) 2106-2114

  37. D. Chan, K. Narayanan, M. F. Leong and A. C. A. Wan, "Induced Pluripotent Stem Cell-Derived Hepatocytes and Endothelial Cells in Multi-Component Hydrogel Fibers for Liver Tissue Engineering," Biomaterials, 35[23] (2014) 6006-6014

  38. K. Kandasamy, K. Narayanan, M. Ni, C. Du, A. C. A. Wan and D. Zink, "Polysulfone Membranes Coated with Polymerized 3,4-dihydroxy-L-phenylalanine are a Versatile and Cost-Effective Synthetic Substrate for Defined Long-Term Cultures of Human Pluripotent Stem Cells," Biomacromolecules, 15[6] (2014) 2067-2078

  39. S. G. Stanciu, S. Xu, Q. Peng, J. Yan, G. A. Stanciu, R. E. Welsch, P. T. C. So, G. Csucs and H. Yu, "Experimenting Liver Fibrosis Diagnostic by Two Photon Excitation Microscopy and Bag-of-Features Image Classification," Scientific Reports, 4 (2014) 4636

  40. A. Bartles, J. Muck, R. S. Dias, A. M. Carnerup, D. Zink and T. Nylander, "DNA Compaction Induced by a Cationic Polymer or Surfactant Impact Gene Expression and DNA Degradation," PLOS ONE, 9[3] (2014) e92692

  41. Y. Loo, Y. Wong, E. Z. Cai, C. Ang, A. Raju, A. Lakshmanan, A. G. Koh, H. J. Zhou, T. Lim, S. M. Moochhala and C. A.E. Hauser, "Ultrashort Peptide Nanofibrous Hydrogels for the Acceleration of Healing of Burn Wounds," Biomaterials, 35[17] (2014) 4805-4814

  42. T. T. Y. Tan, A. Ahsan, M. R. Reithofer, S. W. Tay, S. Y. Tan, T. S. A. Hor, J. M. Chin, B. K. J. Chew and X. Wang, "Photoresponsive Liquid Marbles and Dry Water," Langmuir, 30 (2014) 3448-3454

  43. H. Y. Tiong, P. Huang, S. Xiong, Y. Li, A. Vathsala and D. Zink, "Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models," Molecular Pharmaceutics, (2014) DOI: 10.1021/mp400720w

  44. Y. Li, K. Kandasamy, J. K. C. Chuah, Y. N. Lam, W. S. Toh, Z. Y. Oo and D. Zink, "Identification of Nephrotoxic Compounds with Embryonic Stem Cell-Derived Human Renal Proximal Tubular-Like Cells," Molecular Pharmaceutics, (2014) DOI: 10.1021/mp400637s

  45. J. S. Kochhar, P. Anbalagan, S. B. Shelar, J. K. Neo, C. Iliescu and L. Kang, "Direct Microneedle Array Fabrication of a Photomask to Deliver Collagen Through Skin," Pharmaceutical Research, (2014) DOI: 10.1007/s11095-013-1275-1

  46. H. F. Lu, C. Chai, T. C. Lim, M. F. Leong, J. K. Lim, S. Gao, K. L. Lim and A. C. A. Wan, "A Defined Xeno-Free and Feeder-Free Culture System for the Derivation, Expansion and Direct Differentiation of Transgene-Free Patient-Specific Induced Pluripotent Stem Cells," Biomaterials, (2014) DOI: 10.1016/j.biomaterials.2013.12.050

  47. D. Raghothaman, M. F. Leong, T. C. Lim, J. K. C. Toh, A. C. A. Wan, Z. Yang and E. H. Lee, "Engineering Cell Matrix Interactions in Assembled Polyelectrolyte Fiber Hydrogels for Mesenchymal Stem Cell Chondrogenesis," Biomaterials, (2014) DOI: 10.1016/j.biomaterials.2013.12.008

  48. Q. F. Huang, S. J. Zhang, R. B. Huang, L. Wei, Y. X. Chen, S. J. Lv, C. H. Liang, S. M. Tan, S. Liang, L. Zhuo and X. Lin, "Isolation and Identification of an Anti-Hepatitis B Virus Compound from Hydrocotyle Sibthorpioides Lam," Journal of Ethnopharmacology, 150 (2014) 568-575

  49. S. K. Venkatesh, S. Xu, D. Tai, H. Yu and A. Wee, "Correlation of MR Elastography with Morphometric Quantification of Liver Fibrosis (Fibro-C-Index) in Chronic Hepatitis B," Magnetic Resonance in Medicine, (2013) DOI: 10.1002/mrm.25002

  50. R. Z. Phang, F. C. Tay, S. L. Goh, C. H. Lau, H. B. Zhu, W. K. Tan, Q. L. Liang, C. Chen, S. H. Du, Z. D. Li, J. C. K. Tay, C. X. Wu, J. M. Zeng, W. M. Fan, H. C. Toh, and S. Wang, "Zinc Finger Nuclease-Expressing Baculoviral Vectors Mediate Targeted Genome Integration of Reprogramming Factor Genes to Facilitate the Generation of Human Induced Pluripotent Stem Cells," Stem Cells Translational Medicine, 2 (2013) 935-945

  51. K. Narayanan, V. Y. Lim, J. Shen, Z. W. Tan, D. Rajendran, S.-C. Luo, S. Gao, A. C. A. Wan and J. Y. Ying, "Extracellular Matrix-Mediated Differentiation of Human Embryonic Stem Cells: Differentiation to Insulin-Secreting Beta Cells," Tissue Engineering Part A, 20 (2013) 424-433

  52. A. C. A. Wan and B. C. U. Tai, "Chitin - A Promising Biomaterial for Tissue Engineering and Stem Cell Technologies," Biotechnology Advances, 31[8] (2013) 1776-1785

  53. J. Wei, Q. Huang, R. Huang, Y. Chen, S. Lv, L. Wei, C. Liang, S. Liang, L. Zhuo and X. Lin, "Asiatic Acid from Potentilla Chinensis Attenuate Ethanol-Induced Hepatic Injury via Suppression of Oxidative Stress and Kupffer Cell Activation," Biological and Pharmaceutical Bulletin, 36 (2013) 1980-1989

  54. Q. Huang, R. Huang, L. Wei, Y. Chen, S. Lv, C. Liang, X. Zhang, F. Yin, H. Li, L. Zhuo and X. Lin, "Antiviral Activity of Methyl Helicterate Isolated from Helicteres Angustifolia (Sterculiaceae) against Hepatitis B Virus," Antiviral Research, 100 (2013) 373-381

  55. M. F. Leong, J. K. C. Toh, D. Chan, K. Narayanan, H. F. Lu, T. C. Lim, A. C. A. Wan and J. Y. Ying, "Patterned Prevascularised Tissue Constructs by Assembly of Polyelectrolyte Hydrogel Fibers," Nature Communications, 4 (2013) 2353

  56. D. H. Zheng, G. V. Limmon, L. Yin, N. H. N. Leung, H. Yu, V. T. K. Chow and J. Z. Chen, "A Cellular Pathway Involved in Clara Cell to Alveolar Type II Cell Differentiation after Severe Lung Injury," PLoS One, 8 (2013) e71028

  57. C. G. Anene-Nzelu, K. Y. Peh, A. Fraiszudeen, Y. H. Kuan, S. H. Ng, Y. C. Toh, H. L. Leo and H. Yu, "Scalable Alignment of Three-Dimensional Cellular Constructs in a Microfluidic Chip," Lab on a Chip, 13[20] (2013) 4124-4133

  58. K. Narayanan, S. K. Yen, Q. Dou, P. Padmanabhan, T. Sudhaharan, S. Ahmed, J. Y. Ying and S. T. Selvan, "Mimicking Cellular Transport Mechanism in Stem Cells Through Endosomal Escape of New Peptide-Coated Quantum Dots," Scientific Reports, 3 (2013) 2184

  59. L. P. Saldutti, B. K. Beyer, W. Breslin, T. R. Brown, R. R. Chapin, S. Campion, B. Enright, E. Faustman, P. M. D. Foster, T. Hartung, W. Kelce, J. H. Kim, E. G. Loboa, A. H. Piersma, D. Seyler, K. J. Turner, H. Yu, X. Yu and J. C. Sasaki, "In Vitro Testicular Toxicity Models: Opportunities for Advancement via Biomedical Engineering Techniques," ALTEX Alternatives to Animal Experimentation, 30[3] (2013) 353-377

  60. Y. Li, Z. Y. Oo, S. Y. Chang, P. Huang, K. G. Eng, J. L. Zeng, A. J. Kaestli, B. Gopalan, K. Kandasamy, F. Tasnim and D. Zink, "An In Vitro Method for the Prediction of Renal Proximal Tubular Toxicity in Humans," Toxicology Research, 2[5] (2013) 352-362

  61. A. Lim, M. F. Leong, H. Lu, D. Chan, S. Gao, A. Wan and J. Y. Ying, "Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers," Biomaterials, (2013) DOI: 10.1016/j.biomaterials.2013.05.068

  62. W. Y. Seow, K. Liang, M. Kurisawa, and C. A. E. Hauser, "Oxidation as a Facile Strategy to Reduce the Surface Charge and Toxicity of Polyethyleneimine Gene Carriers," Biomacromolecules, (2013) DOI: 10.1021/bm4004628

  63. G. Tresset, C. Marculescu, A. Salonen, M. Ni and C. Iliescu, "Fine Control over the Size of Surfactant-Polyelectrolyte Nanoparticles by Hydrodynamic Flow Focusing," Analytical Chemistry, 85 (2013) 5850-5856

  64. H. H. Chan, S. Kumar and L. Zhuo, "Neuroprotective and Behavioral Assessments of an Imidazolium Compound (DBZIM) in a Rat Model of Parkinson's Disease Induced by 6-OHDA," European Journal of Pharmacology, 715 (2013) 405–413

  65. M. Khan, K. Narayanan, H. Lu, Y. Choo, C. Du, N. Wiradharma, Y. Y. Yang and A. C. A. Wan, "Delivery of Reprogramming Factors into Fibroblasts for Generation of Non-Genetic Induced Pluripotent Stem Cells Using a Cationic Bolaamphiphile as a Non-Viral Vector," Biomaterials, 34[21] (2013) 5336-5343

  66. C. G. Anene-Nzelu, D. Choudhury, H. Li, A. Fraiszudeen, K. Y. Peh, Y.-C. Toh, S. H. Ng, H. L. Leo and H. Yu, "Scalable Cell Alignment on Optical Media Substrates," Biomaterials, 34[21] (2013) 5078-5087

  67. X. Lin, R. B. Huang, S. J. Zhang, L. Wei, L. Zhuo, X. Y. Wu, A. C. Tang, and Q. F. Huang, "Beneficial Effects of Asiaticoside on Cognitive Deficits in Senescence-Accelerated Mice," Fitoterapia, 87 (2013) 69-77

  68. M. F. Leong, W. Y. Chan and K. S. Chian, "Cryogenic Electrospinning: Proposed Mechanism, Process Parameters and Its Use in Engineering of Bilayered Tissue Structures," Nanomedicine, 8 (2013) 555-566

  69. L. Yin, S. Xu, J. Chen, D. Zheng, G. V. Limmon, N. H. N. Leung, J. C. Rajapakse, V. T. K. Chow, J. Chen and H. Yu, "Spatiotemporal Quantification of Cell Dynamics in the Lung Following Influenza Virus Infection," Journal of Biomedical Optics, 18 (2013) 046001

  70. Q. F. Huang, R. B. Huang, S. J. Zhang, J. Lin, L. Wei, M. He, L. Zhuo and X. Lin, "Protective Effect of Genistein Isolated from Hydrocotyle Sibthorpioides on Hepatic Injury and Fibrosis Induced by Chronic Alcohol in Rats," Toxicology Letter, 217[2] (2013) 102-110

  71. K. Narayanan, K. M. Schumacher, F. Tasnim, K. Kandasamy, A. Schumacher, M. Ni, S. Gao, B. Gopalan, D. Zink and J. Y. Ying, "Human Embryonic Stem Cells Differentiate into Functional Renal Proximal Tubular-Like Cells," Kidney International, 83 (2013) 593-603

  72. Z. B. Ding and L. Zhuo, "Attenuation of Hepatic Fibrosis by an Imidazolium Salt in Thioacetamide-Induced Mouse Model," Journal of Gastroenterology and Hepatology, 28[1] (2013) 188-201

  73. T. C. Lim, S. Rokkappanavar, W. S. Toh, L. S. Wang, M. Kurisawa, and M. Spector, "Chemotactic Recruitment of Adult Neural Progenitor Cells into Multifunctional Hydrogels Providing Sustained SDF-1α Release and Compatible Structural Support," The FASEB Journal, (2012) DOI: 10.1096/fj.12-221515

  74. A. Lakshmanana, D. W. Cheong, A. Accardoc, E. D. Fabrizioc, C. Riekeld, and C. A. E. Hauser, "Aliphatic Peptides Show Similar Self-Assembly to Amyloid Core Sequences, Challenging the Importance of Aromatic Interactions in Amyloidosis," Proceedings of the National Academy of Sciences, (2012) DOI: 10.1073/pnas.1217742110

  75. J. M. Chin, M. R. Reithofer, T. T. Y. Tan, A. G. Menon, E. Y. Chen, C. A. Chow, A. T. S. Hora and J. Xu, "Supergluing MOF Liquid Marbles," Chemical Communications, 49 (2013) 493-495

  76. H. F. Lu, S.-X. Lim, M. F. Leong, K. Narayanan, R. P.K. Toh, S. Gao and A. C. A. Wan, "Efficient Neuronal Differentiation and Maturation of Human Pluripotent Stem Cells Encapsulated in 3D Microfibrous Scaffolds," Biomaterials, (2012) DOI: 10.1016/j.biomaterials.2012.09.006

  77. L. Xia, T. Arooz, S. Zhang, X. Tuo, G. Xiao, T. A. K. Susanto, J. Sundararajan, T. Cheng, Y. Kang, H. J. Poh, H. L. Leo and H. Yu, "Hepatocyte Function Within a Stacked Double Sandwich Culture Plate Cylindrical Bioreactor for Bioartificial Liver System," Biomaterials, 33[32] (2012) 7925-7932

  78. J. S. Muck, K. Kandasamy, A. Englmann, M. Günther and D. Zink, "Perinuclear Positioning of the Inactive Human Cystic Fibrosis Gene Depends on CTCF, A-Type Lamins and an Active Histone Deacetylase," Journal of Cellular Biochemistry, 113[8] (2012) 2607-2621

  79. N-A. M. Suhaimi and L. Zhuo, "Imidazolium Salt Attenuates Thioacetamide-Induced Liver Fibrosis in Mice by Modulating Inflammation and Oxidative Stress," Digestive and Liver Disease, (2012) DOI: 10.1016/j.dld.2012.02.015

  80. C. Iliescu, H. Taylor, M. Avram, J. Miao and S. Franssila, "A Practical Guide for the Fabrication of Microfluidic Devices Using Glass and Silicon," Biomicrofluidics, 6[1] (2012) 016505

  81. F. Tasnim and D. Zink, "Cross Talk Between Primary Human Renal Tubular Cells and Endothelial Cells in Cocultures," American Journal of Physiology - Renal Physiology, 302[8] (2012) F1055-F1062

  82. A. Lakshmanan, S. Zhang and C. A. E. Hauser, "Short Self-Assembling Peptides as Building Blocks for Modern Nanodevices," Trends in Biotechnology, 30[3] (2011) 155-165

  83. H. F. Lu, K. Narayanan, S-X Lim, S. Gao, M. F. Leong and A. C. A. Wan, "A 3D Microfibrous Scaffold for Long-Term Human Pluripotent Stem Cell Self-Renewal Under Chemically Defined Conditions," Biomaterials, 33[8] (2012) 2419-2430

  84. E. C. Wu, S. Zhang and C. A. E. Hauser, "Self-Assembling Peptides as Cell-Interactive Scaffolds," Advanced Functional Materials, 22[3] (2012) 456-468

  85. L. Xia, R. B. Sakban, Y.Qu, X. Hong, W. Zhang, B. Nugraha, W. H. Tong, A. Ananthanarayanan, B. Zheng, I. Y-Y Chau, R. Jia, M. McMillian, J. Silva, S. Dallas and H. Yu, "Tethered Spheroids as an In Vitro Hepatocyte Model for Drug Safety Screening," Biomaterials, 33[7] (2011) 2165-2176

  86. A. C. A. Wan, M. F. Leong, J. K. C. Toh, Y. Zheng and J. Y. Ying, "Multicomponent Fibers by Multi-Interfacial Polyelectrolyte Complexation," Advanced Healthcare Materials, 1[1] (2011) 101-105

  87. D. Choudhury, D. v. Noort, C. Iliescu, B. Zheng, K-L. Poon, S. Korzh, V. Korzh and H. Yu, "Fish and Chips: A Microfluidic Perfusion Platform For Monitoring Zebrafish Development," Lab on a Chip, 12[5] (2011) 892-900

  88. T. M. Hsieh, A. C. A. Wan and J. Y. Ying, "Applications of Fabricated Micro- and Nanostructures in Biomedicine," MRS Bulletin, 36[12] (2011) 990-997

  89. J Lin, F. Lu, W. Zheng, S. Xu, D. Tai, H. Yu and Z. Huang, "Assessment of Liver Steatosis and Fibrosis in Rats Using Integrated Coherent Anti-Stokes Raman Scattering and Multiphoton Imaging Technique," Journal of Biomedical Optics, 16[11] (2011) 116024

  90. R. Magalhães, B. Nugraha, S. Pervaiz, H. Yu and L. L. Kuleshova, "Influence of Cell Culture Configuration on the Post-Cryopreservation Viability of Primary Rat Hepatocytes," Biomaterials, 33[3] (2011) 829-836

  91. B. Zheng, L. Tan, X. Mo, W. Yu, Y. Wang, L.Tucker-Kellogg, R. E. Welsch, P. T. C. So and H. Yu, "Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis," PLoS ONE, 6[11] (2011) e26230

  92. Y. C. Toh, K. Blagovic, H. Yu and J. Voldman, "Spatially Organized In Vitro Models Instruct Asymmetric Stem Cell Differentiation," Integrative Biology, 3[12] (2011) 1179-1187

  93. F. Tasnim, K. Kandasamy, J. S. Muck, M. S. bin Ibrahim, J. Y. Ying and D. Zink, "Effects of BMPs on Primary Human Renal Cells and the Generation of BMP-7-Expressing Cells for Applications in Bioartificial Kidneys," Tissue Engineering Part A, 18[3-4] (2011) 262-276

  94. F. Zhuang, K. Oglecka and C. A. E. Hauser, "Self-Assembling Peptide Surfactants A6K and A6D Adopt α-Helical Structures Useful for Membrane Protein Stabilization," Membranes, 1[4] (2011) 314-326

  95. M. Ni, P. K. Zimmermann, K. Kandasamy, W. Lai, Y. Li, M. F. Leong, A. C. A. Wan and D. Zink, "The Use of a Library of Industrial Materials to Determine the Nature of Substrate-Dependent Performance of Primary Adherent Human Cells," Biomaterials, 33[2] (2012) 353-364

  96. Y. Loo, S. Zhang and C. A. E. Hauser, "From Short Peptides to Nanofibers to Macromolecular Assemblies in Biomedicine," Biotechnology Advances, 30[3] (2011) 593-603

  97. L. Venkatraman, H. Li, C. F. Dewey, J. K. White, S. S. Bhowmick, H. Yu and L. Tucker-Kellogg, "Steady States and Dynamics of Urokinase-Mediated Plasmin Activation In Silico and In Vitro," Biophysical Journal, 101[8] (2011) 1825-1834

  98. A. Lakshmanan and C. A. E. Hauser, "Ultrasmall Peptides Self-Assemble into Diverse Nanostructures: Morphological Evaluation and Potential Implications," International Journal of Molecular Sciences, 12[9] (2011) 5736-5746

  99. Y. O. Zay, R. Deng, M. Hu, M. Ni, K. Kandasamy, M. S. bin Ibrahim, J. Y. Ying and D. Zink, "The Performance of Primary Human Renal Cells in Hollow Fiber Bioreactors for Bioartificial Kidneys," Biomaterials, 32[34] (2011) 8806-8815

  100. S. L. J. Ng, K. Narayanan, S. Gao and A. C. A. Wan, "Lineage Restricted Progenitors for the Repopulation of Decellularized Heart," Biomaterials, 32[30] (2011) 7571-7580

  101. E. Tamariz, A. C. A. Wan, Y. S. Pek, M. Giordano, G. Hernández-Padrón, A. Varela-Echavarría, I. Velasco and V. M. Castaño, "Delivery of Chemotropic Proteins and Improvement of Dopaminergic Neuron Outgrowth Through a Thixotropic Hybrid Nano-Gel," Journal of Materials Science: Materials in Medicine, 22[9] (2011) 2097-2109

  102. B. Nugraha, X. Hong, X. Mo, L. Tan, W. Zhang, P-M. Chan, C. H. Kang, Y. Wang, L. T. Beng, W. Sun, D. Choudhury, J. M. Robens, M. McMillian, J. Silva, S. Dallas, C-H. Tan, Z. Yue and H. Yu, "Galactosylated Cellulosic Sponge for Multi-Well Drug Safety Testing," Biomaterials, 32[29] (2011) 6982-6994

  103. Y. S. Pek and A. C. A. Wan, "Characterization of Early Extracellular Matrix Secretions in a Three-Dimensional Thixotropic Cell Culture System," Acta Biomaterialia, 7[11] (2011) 3981-3987

  104. D. Choudhury, X. Mo, C. Iliescu, L. L. Tan, W. H. Tong and H. Yu, "Exploitation of Physical and Chemical Constraints for Three-Dimensional Microtissue Construction in Microfluidics," Biomicrofluidics, 5 (2011) 22203

  105. G. Maubach, M. C. C. Lim, J. Chen, H. Yang and L. Zhuo, "miRNA Studies in In Vitro and In Vivo Activated Hepatic Stellate Cells," World Journal of Gastroenterology, 17[22] (2011) 2748-2773

  106. A. Mishra, Y. Loo, R. Deng, Y. J. Chuah, H. T. Hee, J. Y. Ying and C. A. E Hauser, "Ultrasmall Natural Peptides Self-Assemble to Strong Temperature-Resistant Helical Fibers in Scaffolds Suitable for Tissue Engineering," Nano Today, 6 (2011) 232-239

  107. Y. Li, Y. Zheng, K. Zhang, J. Y. Ying and D. Zink, "Effects of Quantum Dots on Different Renal Proximal Tubule Cell Models and on Gel-Free Renal Tubules Generated In Vitro," Nanotoxicology, 6[2] (2011) 121-133

  108. J. ZHou, C. Bi, W.-J. Chng, L.-L. Cheong, S.-C. Liu, S. Mahara, K.-G. Tay, Q. Zeng, J. Li, K. Guo, C. P. B. Tan, H. Yu, D. H. Albert and C.-S. Chen, "PRL-3, A Metastasis Associated Tyrosine Phosphatase, is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy," PLoS ONE, 6 (2011) e19798

  109. B. Jakob, J, Splinter, S. Conrad, K.-O. Voss, D. Zink, M. Durante, M. Loebrich and G. Taucher-Scholz, "DNA Double-Strand Breaks in Heterochromatin Elicit Fast Repair Protein Recruitment, Histone H2AX Phosphorylation and Relocation to Euchromatin," Nucleic Acids Research, 39 (2011) 6489-6499

  110. K. Subramaniam, K. Kandasamy, K. Joseph, E. K. Spicer and B. G. Tholanikunnel, "3\'-Untranslated Region Length and AU-Rich RNA Location Modulate RNA-Protein Interaction and Translational Control of β2-Adrenergic Receptor mRNA," Molecular and Cellular Biochemistry, 352[1-2] (2011) 125-141(17)

  111. Z. Ding, Y. Kng, H. Yang, Z. Ke and L. Zhuo, "An Orally Available Small Imidazolium Salt Ameliorates Inflammation and Fibrosis in a Murine Model of Cholestasis," Laboratory Investigation, 91 (2011) 752-763

  112. B. Gopalan, Z. Ke, C. Zhang, Y. Kng, N. A. Suhaimi, S. N. Riduan, Y. Zhang and L. Zhuo, "Metal-Free Imidazolium Salts Inhibit the Growth of Hepatocellular Carcinoma in a Mouse Model," Laboratory Investigation, 91 (2011) 744-751

  113. S. Kumar and L. Zhuo, "Quantitative Analysis of Pupillary Light Reflex by Real-Time Autofluorescent Imaging in a Diabetic Mouse Model," Experimental Eye Research, 92[3] (2011) 4-172

  114. D. Berchtold, S. Fesser, G. Bachmann, A. Kaiser, J. C. Eilert, F. Frohns, N. Sadoni, J. Muck, E. Kremmer, D. Eick, P. G. Layer and D. Zink, "Nuclei of Chicken Neurons in Tissues and Three-Dimensional Cell Cultures are Organized into Distinct Radial Zones," Chromosome Research, 19[2] (2011) 165-182

  115. C. Anene-Nzelu, Y. Wang, H. Yu and H. L. Leo, "Liver Tissue Model for Drug Toxicity Screening," Journal of Mechanics in Medicine and Biology, 11[2] (2011) 369-390

  116. M. Ni, J. C .M. Teo, M. S. bin Ibrahim, K. Zhang, F. Tasnim, P.-Y. Chow, D. Zink and J. Y. Ying, "Characterization of Membrane Materials and Membrane Coatings for Bioreactor Units of Bioartificial Kidneys," Biomaterials, 32[6] (2010) 1465-1476

  117. C. A. E. Hauser, R. Deng, A. Mishra, Y. Loo, U. Khoe, F. Zhuang, D. W. Cheong, A. Accardo, M. B. Sullivan, C. Riekel, J. Y. Ying and U. A. Hauser, "Natural tri- to hexapeptides self-assemble in water to amyloid β-type fiber aggregates by unexpected α-helical intermediate structures," Proceedings of the National Academy of Sciences, 108[4] (2011) 1361-1366

  118. A. Ananthanarayanan, B. C. Narmada, X. Mo, M. McMillian and H. Yu, "Purpose-Driven Biomaterials Research in Liver Tissue Engineering," Trends in Biotechnology, 29[3] (2010) 110-118

  119. C. Hauser and S. Zhang, "Nanotechnology: Peptides as Biological Semiconductors," Nature, 468[7323] (2010) 516-517

  120. J. H. Song, K. Kandasamy, M. Zemskova, Y-W. Lin and A. S. Kraft, "The BH3 Mimetic ABT-737 Induces Cancer Cell Senescence," Cancer Research, 71[2] (2010) 506-515

  121. X. Zhang, Y. H. Tee, J. K. Heng, Y. Zhu, X. Hu, F. Margadant, C. Ballestrem, A. Bershadsky, G. Griffiths and H. Yu, "Kinectin-Mediated Endoplasmic Reticulum Dynamics Supports Focal Adhesion Growth in the Cellular Lamella," Journal of Cell Science, 123[22] (2010) 3901-3912

  122. S. Zhang, W. H. Tong, B. Zheng, T. A. K. Susanto, L. Xia, C. Zhang, A. Ananthanarayanan, X. Tuo, R. B. Sakban, R. R. Jia, C. Iliescu, K. H. Chai, M. McMillian, S. Shen, H. L. Leo and H. Yu, "A Robust High-Throughput Sandwich Cell-Based Drug Screening Platform," Biomaterials, 32[4] (2010) 1229-1241

  123. A. M. Raja, S. Xu, W. Sun, J. Zhou, D. C. S. Tai, C. S. Chen, J. C. Rajapakse, P. T. C. So and H. Yu, "Pulse-Modulated Second Harmonic Imaging Microscope Imaging Quantitatively Demostrates Marked Increase of Collagen in Tumor After Chemotherapy," Journal of Biomedical Optics, 15[5] (2010) 056016

  124. C. Hauser and S. Zhang, "Designer Self-Assembling Peptide Materials for Diverse Applications," Macromolecular Symposia, 295[1] (2010) 30-48

  125. Y. Wei, J. Yang, A. W. H. Lin and J. Y. Ying, "A Highly Reactive Se Precursor for the Phosphine-Free Synthesis of Metal Selenide Nanocrystals," Chemistry of Materials, 22[20] (2010) 5672-5677

  126. Y. He, C. H. Kang, S. Xu, X. Tuo, S. L. Trasti, D. C. S. Tai, A. M. Raja, Q. Peng, P. T. C. So, J. C. Rajapakse, R. Welsch and H. Yu, "Towards Surface Quantification of Liver Fibrosis Progression," Journal of Biomedical Optics, 15[5] (2010) 056007

  127. Z. Yue, F. Wen, S. Gao, M. Y. Ang, P. K. Pallathadka, L. Liu and H. Yu, "Preparation of Three-Dimensional Interconnected Macroporous Cellulosic Hydrogels for Soft Tissue Engineering," Biomaterials, 31[32] (2010) 8141-8152

  128. F. Tasnim, R. Deng, M. Hu, S. Liour, Y. Li, M. Ni, J. Y. Ying and D. Zink, "Achievements and Challenges in Bioartificial Kidney Development," Fibrogenesis and Tissue Repair, 3[14] (2010)

  129. T. M. Hsieh, C. W. B. Ng, K. Narayanan, A. C. A. Wan and J. Y. Ying, "Three-Dimensional Microstructured Tissue Scaffolds Fabricated by Two-Photon Laser Scanning Photolithography," Biomaterials, 31[30] (2010) 7648-7652

  130. S. Kumar and L. Zhuo, "Longitudinal In Vivo Imaging of Retinal Gliosis in a Diabetic Mouse Model," Experimental Eye Research, 91[4] (2010) 530-536

  131. K. Saravana, S. H. Ong and K. S. W. Tan, "Robust Contour Reconstruction of Red Blood Cells and Parasites in the Automated Identification of the Stages of Malarial Infection," Machine Vision and Application, 22[3] (2010) 461-469

  132. X. Mo, Q. Li, L. W. Y. Lui, B. Zheng, C. H. Kang, B. Nugraha, Z. Yue, R. R. Jia, H. X. Fu, D. Choudhury, T. Arooz, J. Yan, C. T. Lim, S. Shen, C. H. Tan and H. Yu, "Rapid Construction of Mechanically-Confined Multi-Cellular Structures Using Dendrimeric Intercellular Linker," Biomaterials, 31[29] (2010) 7455-7467

  133. H. Zhang, S. F.-T. Lau, B. F. Heng, P. Y. Teo, P. K. D. Thilini Alahakoon, M. Ni, F. Tasnim, J. Y. Ying and D. Zink, "Generation of Easily Accessible Human Kidney Tubules on Two-Dimensional Surfaces In Vitro," Journal of Cellular and Molecular Medicine, 15[6] (2010) 1287-1298

  134. C. A. E. Hauser and S. Zhang, "Designer Self-Assembling Peptide Nanofiber Biological Materials," Chemical Society Reviews, 39[8] (2010) 2780-2790

  135. X. Zhao, F. Pan, H. Xu, M. Yaseen, H. Shan, C. A. E. Hauser, S. Zhang and J. R. Lu, "Molecular Self-Assembly and Applications of Designer Peptide Amphiphiles," Chemical Society Reviews, 39[9] (2010) 3480-3498

  136. B. C. U. Tai, A. C. A. Wan and J. Y. Ying, "Modified Polyelectrolyte Complex Fibrous Scaffold as a Matrix for 3D Cell Culture," Biomaterials, 31[23] (2010) 5927-5935

  137. G. Ho, K. Saravana, Z. Y. Ke, H. N. Chan, N. Mohamed Suhaimi, Y. L. Kng, Y. Zhang and L. Zhuo, "Imidazolium Salt (DBZIM) Reduces Gliosis in Mice Treated with Neurotoxicant 2'-CH3-MPTP," CNS Neuroscience & Therapeutics, 17[3] (2010) 148-157

  138. Y. Wei, J. Yang and J. Y. Ying, "Reversible Phase Transfer of Quantum Dots and Metal Nanoparticles," Chemical Communications, 46[18] (2010) 3179-3181

  139. G. Xing, J. Jiang, J. Y. Ying and W. Ji, "Fe3O4-Ag Nanocomposites for Optical Limiting: Broad Temporal Response and Low Threshold," Optics Express, 18[6] (2010) 6183-6190

  140. A. Rebuffat, C. O. Harding, Z. Ding and B. Thony, "Comparison of Adeno-Associated Virus Pseudotype 1, 2 and 8 Vectors Administered by Intramuscular Injection in the Treatment of Murine Phenylketonuria," Human Gene Therapy, 21[4] (2010) 463-477

  141. W. Zhang, L. Tucker-Kellogg, B. C. Narmada, L. Venkatraman, S. Chang, L. Ying, N. Tan, J. K. White, R. R. Jia, S. S. Bhowmick, S. Shen, C. F. Dewey, Jr. and H. Yu, "Cell Delivery Therapeutics for Liver Regeneration," Advanced Drug Delivery Reviews, 62[7-8] (2010) 814-826

  142. S. J. Tan, N. R. Jana, S. Gao, P. K. Patra and J. Y. Ying, "Surface Ligand-Dependent Cellular Interaction, Subcellular Localization and Cytotoxicity of Polymer-Coated Quantum Dots," Chemistry of Materials, 22[7] (2010) 2239-2247

  143. A. C. A. Wan and J. Y. Ying, "Nanomaterials for In Situ Delivery and Tissue Regeneration," Advanced Drug Delivery Reviews, 62[7-8] (2010) 731-740

  144. J. Yang and J. Y. Ying, "Diffusion of Gold from the Inner Core to the Surface of Ag2S Nanocrystals," Journal of the American Chemical Society, 132[7] (2010) 2114-2115

  145. N. R. Jana. N. Erathodiyil, J. Jiang and J. Y. Ying, "Cysteine-Functionalized Polyaspartic Acid: A Polymer for Coating and Bioconjugation of Nanoparticles and Quantum Dots," Langmuir, 26[9] (2010) 6503-6507

  146. R. Hortsch, E. Lee, N. Erathodiyil, S. Hebbar, S. Steinert, J. Y. Lee, D. S. K. Chua and R. Kraut, "Glycolipid Trafficking in Drosophila Undergoes Pathway Switching in Response to Aberrant Cholesterol Levels," Molecular Biology of the Cell, 21[5] (2010) 778-790

  147. M. Ni, W.H. Tong, D. Choudhury, C. Iliescu and H. Yu, "Cell Culture on MEMS Platforms: A Review," International Journal of Molecular Sciences, 10[12] (2009) 5411-5441

  148. L. S. Wang, J. E. Chung, P. Chan and M. Kurisawa, "Injectable Biodegradable Hydrogels with Tunable Mechanical Properties for the Stimulation of Neurogenesic Differentiation of Human Mesenchymal Stem Cells in 3D Culture," Biomaterials, 31[6] (2009) 1148-1157

  149. S. M. Ong, Z. Zhao, T. Arooz, D. Zhao, S. Zhang, T. Du, M. Wasser, D. van Noort and H. Yu, "Engineering a Scaffold-Free 3D In Vitro Tumor Model for In Vitro Drug Penetration Studies," Biomaterials, 31[6] (2009) 1180-1190

  150. M. Hu, R. Deng, K. M. Schumacher, M. Kurisawa, H. Ye, K. Purnamawati and J. Y. Ying, "Hydrodynamic Spinning of Hydrogel Fibers," Biomaterials, 31[5] (2009) 863-869

  151. W. Xiang, Z. Ke, Y. Zhang, G. H. Cheng, I. D. Irwan, K. N. Sulochana, P. Potturi, Z. Wang, H. Yang, J. Wang, L. Zhuo, R. M. Kini and R. Ge, "Isthmin is a Novel Secreted Angiogenesis Inhibitor that Inhibits Tumor Growth in Mice," Journal of Cellular and Molecular Medicine, 15[2] (2009) 359-374

  152. C. Zhang, D. Zhao, N. A. Abdul Rahim, D. van Noort and H. Yu, "Towards a Human-on-Chip: Culturing Multiple Cell Types on a Chip with Compartmentalized Microenvironments," Lab on a Chip, 9[22] (2009) 3185-3192

  153. Y. S. Pek, A. C. A. Wan and J. Y. Ying, "The Effect of Matrix Stiffness on Mesenchymal Stem Cell Differentiation in a 3D Thixotropic Gel," Biomaterials, 31[3] (2009) 385-391

  154. B. C. U. Tai, D. Chan, S. J. Gao, A. C. A. Wan and J. Y. Ying, "The Use of a Polyelectrolyte Fibrous Scaffold to Deliver Differentiated hMSCs to the Liver," Biomaterials, 31[1] (2009) 48-57

  155. M. C. C. Lim, G. Maubach and L. Zhuo, "TGF-β1 Down-regulates Connexin 43 Expression and Gap Junction Intercellular Communication in Rat Hepatic Stellate Cells," European Journal of Cell Biology, 88[12] (2009) 719-730

  156. J. Xu, D. Li, Z. Y. Ke, R. M. Liu, G. Maubach and L. Zhuo, "Cathepsin S is Aberrantly Overexpressed in Human Hepatocellular Carcinoma," Molecular Medicine Reports, 2[5] (2009) 713-718

  157. Y. Wei, N. R. Jana, S. Tan, and J. Y. Ying, "Surface Coating Directed Cellular Delivery of TAT-Functionalized Quantum Dots," Bioconjugate Chemistry, 20[9] (2009) 1752-1758

  158. C. Y. Zhang, Z. B. Ding, N. Mohamed Suhaimi, Y. L. Kng, Y. Zhang and L. Zhuo, "A Class of Imidazolium Salts is Anti-Oxidative and Anti-Fibrotic in Hepatic Stellate Cells," Free Radical Research, 43[10] (2009) 899-912

  159. S. Kumar, S. H. Ong, S. Ranganath and F. T. Chew, "Invariant Texture Classification for Biomedical Cell Specimens via Non-Linear Polar Map Filtering," Computer Vision and Image Understanding, 114[1] (2009) 44-53

  160. L. Xia, S. Ng, R. Han, X. Tuo, H. L. Leo and H. Yu, "Laminar-Flow Immediate-Overlay Hepatocyte Sandwich Perfusion System for Drug Hepatoxicity Testing," Biomaterials, 30[30] (2009) 5927-5936

  161. D. Tai, N. Tan, S. Y. Xu, C. H. Kang, S. M. Chia, C. L. Cheng, A. Wee, L. W. Chiang, A. M. Raja, G. F. Xiao, J. C. Rajapakse, P. So and H. Yu, "Fibro-C-Index - A Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-Photon Microscopy," Journal of Biomedical Optics, 14[4] (2009) 044013

  162. J. Muck and D. Zink, "Nuclear Organization and Dynamics of DNA Replication in Eukaryotes," Frontiers in Bioscience, 14 (2009) 5361-5371

  163. R. Magalhaes, P. R. Anil Kumar, F. Wen, X. Zhao, H. Yu and L. L. Kuleshova, "The Use of Vitrification to Preserve Primary Rat Hepatocyte Monolayer on Collagen-Coated Poly(ethylene-terephthalate) Surfaces for a Hybrid Liver Support System," Biomaterials, 30[25] (2009) 4136-4142

  164. K. Narayanan, K-J. Leck, S. Gao and A. C.A. Wan, "Three-Dimensional Reconstituted Extracellular Matrix Scaffolds for Tissue Engineering," Biomaterials, 30[26] (2009) 4309-4317

  165. J. Yang and J. Y. Ying, "Room-Temperature Synthesis of Nanocrystalline Ag2S and Its Nanocomposites with Gold," Chemical Communications, 1[22] (2009) 3187-3189

  166. C. Zhang, S. M. Chia, S. M. Ong, S. Zhang, Y. C. Toh, D. van Noort and H. Yu, "The Controlled Presentation of TGF-β1 to Hepatocytes in a 3D Microfludic Cell Culture System," Biomaterials, 30[23-24] (2009) 3847-3853

  167. E. Fedorova and D. Zink, "Nuclear Genome Organization: Common Themes and Individual Patterns," Current Opinion in Genetics and Development, 19[2] (2009) 166-171

  168. X. Pan, X. Shi, V. Korzh, H. Yu and T. Wohland, "Line Scan Fluorescence Correlation Spectroscopy for 3D Microfluidic Flow Velocity Measurements," Journal of Biomedical Optics, 14[2] (2009) 024049

  169. H. Zhang, F. Tasnim, J. Y. Ying and D. Zink, "The Impact of Extracellular Matrix Coatings on the Performance of Human Renal Cells Applied in Bioartificial Kidneys," Biomaterials, 30[15] (2009) 2899-2911

  170. W. E. Maalouf, Z. Liu, V. Brochard, J. P. Renard, P. Debey, N. Beaujean and D. Zink, "Trichostatin A Treatment of Cloned Mouse Embryos Improves Constitutive Heterochromatin Remodeling as Well as Developmental Potential to Term," BMC Developmental Biology, 9:11 (2009)

  171. D. Van Noort, S. M. Ong, C. Zhang, S. Zhang, T. Arooz and H. Yu, "Stem Cells in Microfluidics," Biotechnology Progress, 25[1] (2009) 52-60

  172. A. Lim and R. Kraut, "The Drosophila BEACH Family Protein, Blue Cheese, Links Lysosomal Axon Transport with Motorneuron Degeneration," Journal of Neuroscience, 29[4] (2009) 951-963

  173. G. Ho, S. Kumar, X. S. Min, Y. L. Kng, M. Y. Loh, S. J. Gao, and L. Zhuo, "Molecular Imaging of Retinal Gliosis in Transgenic Mice Induced by Kainic Acid Neurotoxicity," Investigative Opthalmology and Visual Science, 50[5] (2009) 2459-2464

  174. J. Zhou, C. Bi, J. Janakaumara, S. C. Liu, W. J. Chng, K. G. Tay, L. F. Poon, Z. Xie, P. Senthilnathan, H. Yu, K. B. Glaser, D. Albert, S. Davidsen and C. S. Chen, "Enhanced Activation of STAT Pathways and Overexpression of Survivin Confer Resistance to FLT3 Inhibitors and Could Be Therapeutic Targets in AML," Blood, 113[17] (2009) 4052-4062

  175. G. Xing, W. Ji, Y. Zheng and J. Y. Ying, "Two- and Three-Photon Absorption of Semiconductor Quantum Dots in the Vicinity of Half of Lowest Excitation Energy," Applied Physics Letters, 93[24] (2008) 241114-1-241114-3

  176. C. Y. Ang, L. Giam, Z. M. Chan, A. W. H. Lin, H. Gu, E. Devlin, G. C. Papaefthymiou, S. T. Selvan and J. Y. Ying, "Facile Synthesis of Fe2O3 Nanocrystals without Fe(CO)5 Precursor and One-Pot Synthesis of Highly Fluorescent Fe2O3-CdSe Nanocomposites," Advanced Materials, 21[8] (2009) 869-873

  177. W. X. Sun, S. Chang, D. Tai, N. Tan, G. F. Xiao, H. H. Tang and H. Yu, "Non-Linear Optical Microscopy: Use of Second Harmonic Generation and Two-Photon Microscopy for Automated Quantitative Liver Fibrosis Studies," Journal of Biomedical Optics, 13[6] (2008) 064010

  178. P. Liu, Y. W. Zhang, H. Yu, X. Zhang, Q. H. Cheng, C. Lu and W. Bonfield, "Spreading of an Anchorage-Dependent Cell on a Selectively Ligand-Coated Substrate Mediated by Receptor-Ligand Binding," Journal of Biomedical Materials Research Part A, 91A[3] (2009) 806-813

  179. Y. S. Pek, M. Kurisawa, S. Gao, J. E. Chung and J. Y. Ying, "The Development of a Nanocrystalline Apatite Reinforced Crosslinked Hyaluronic Acid-Tyramine Composite as an Injectable Bone Cement," Biomaterials, 30[5] (2009) 822-828

  180. S. Kumar, Y.Wang, V. Viswanathan and R. Kraut, "Multivariate Profiling of Neurodegeneration-Associated Changes in a Subcellular Compartment of Neurons via Image Processing," BioData Mining, 1[10] (2008) 1-10

  181. J. Jiang, H. W. Gu, H. Shao, E. Devlin, G. C. Papaefthymiou and J. Y. Ying, "Bifunctional Fe3O4-Ag Heterodimer Nanoparticles for Two- Photon Fluorescence Imaging and Magnetic Manipulations," Advanced Materials, 20[23] (2008) 4403-4407

  182. Y. S. Pek, A. C. A. Wan, A. Shekaran, L. Zhuo and J. Y. Ying, "Thixotropic Gels for Three Dimensional Cell Culture," Nature Nanotechnology, 3 (2008) 671-675

  183. Y. Zheng, Z. Yang, Y. Li and J. Y. Ying, "From Glutathione Capping to Crosslinked, Phytochelatin-Like Coating of Quantum Dots," Advanced Materials, 20[18] (2008) 3410-3415

  184. Y. S. Pek, S. Gao, M. S. Mohamed Arshad, K. J. Leck and J. Y. Ying, "Porous Collagen-Apatite Nanocomposite Foams as Bone Regeneration Scaffolds," Biomaterials, 29[32] (2008) 4300-4305

  185. S. Steinert , E. Lee, G. Tresset, R. Wetzel, D. Zhang, S. Hebbar, R. Hortsch, J. R. Sundram, S. Kesavapany, E. Boschke and R. Kraut, "A Fluorescent Glycolipid-Binding Peptide Probe Traces Cholesterol Dependent Microdomain-Derived Trafficking Pathways," PLoS-1, 3[8] (2008) e2933

  186. E. Federova and D. Zink, "Nuclear Architecture and Gene Regulation," Biochimica et Biophysica Acta - Molecular Cell Research, 1783[11] (2008) 2174-2184

  187. G. Maubach, M. C. C. Lim and L. Zhuo, "Nuclear Cathepsin F Regulates Activation Markers in Rat Hepatic Stellate Cells," Molecular and Biology of the Cell, 19[10] (2008) 4238-4248

  188. G. Ho, S. Kumar, C. Y. Zhang, Y. L. Kng and L. Zhuo, "Molecular Imaging Reveals a Correlation Between 2\'-CH3-MPTP-Induced Neonatal Neurotoxicity and Dopaminergic Neurodegeneration in Adult Transgenic Mice," International Journal of Developmental Neuroscience, 26[7] (2008) 673-681

  189. S. F. Zhang, X. Lei, S. M. Ong, Y. C. Toh, H. L. Leo, D. van Noort and H. Yu, "Microfabricated Silicon Nitride Membranes for Hepatocyte Sandwich Culture," Biomaterials, 29[29] (2008) 3993-4002

  190. Z. Ding, G. Maubach, A. Masamune and L. Zhuo, "Glial Fibrillary Acidic Protein Promoter Targets Pancreatic Stellate Cells," Digestive and Liver Disease, 41[3] (2009) 229-236

  191. D. Zhao, S. M. Ong, Z. Yue, Z. Jiang, Y. C. Toh, M. Khan, J. Shi, C. H. Tan, J. P. Chen and H. Yu, "Dendrimer Hydrazides as Multivalent Transient Inter-Cellular Linkers," Biomaterials, 29[27] (2008) 3693-3702

  192. E. Federova, N. Sadoni, I. K. Dahlsveen, J. Koch, E. Kremmer, D. Eick, R. Paro and D. Zink, "The Nuclear Organization of Polycomb/Trithorax Group Response Elements in Larval Tissues of Drosophila Melanogaster," Chromosome Research, 16[4] (2008) 649-673

  193. S. Kumar, G. Ho, K. M. Woo and L. Zhuo, "Achieving Cellular Resolution for In Vivo Retinal Images of Transgenic GFAP-GFP Mice via Image Processing," Optics Express, 16[11] (2008) 8250-8262

  194. R. F. Luco, M. A. Maestro, N. Sadoni, D. Zink and J. Ferrer, "Targeted Deficiency of the Transcriptional Activator HNF1a Alters Subnuclear Positioning of Its Genomic Targets," PLoS Genetics, 4[5] (2008) e1000079

  195. C. Earhart, N. R. Jana, N. Erathodiyil and J. Y. Ying, "Synthesis of Carbohydrate-Conjugated Nanoparticles and Quantum Dots," Langmuir, 24[12] (2008) 6215-6219

  196. Y. Han, J. Jiang, S. S. Lee and J. Y. Ying, "Reverse Microemulsion Mediated Synthesis of Silica-Coated Gold and Silver Nanoparticles," Langmuir, 24[11] (2008) 5842-5848

  197. S. M. Ong, C. Zhang, Y. C. Toh, S. H. Kim, H. L. Foo, C. H. Tan, D. van Noort, S. Park and H. Yu, "A Gel-Free 3D Microfluidic Cell Culture System," Biomaterials, 29[22] (2008) 3237–3244

  198. N. Erathodiyil, N. R. Jana and J. Y. Ying, "Functionalization of Gold Nanospheres and Nanorods by Chitosan Oligosaccharide Derivatives," Advanced Materials, 20[11] (2008) 2068-2073

  199. F.Wen, S. Chang, Y. C. Toh, T. Arooz, L. Zhuo, S. H. Teoh and H. Yu, "Development of Dual-Compartment Perfusion Bioreactor for Serial Co-Culture of Hepatocytes and Stellate Cells in Poly (Lactic-Co Glycolic Acid)-Collagen Scaffolds," Journal of Biomedical Materials Research: Part B Applied Biomaterials, 87B[1] (2008) 154-162

  200. G. Xing, W. Ji, Y. G. Zheng and J. Y. Ying, "High Efficiency and Nearly Cubic Power Dependence of Below-Band-Edge Photoluminescence in Water-Soluble, Copper-Doped ZnSe/ZnS Quantum Dots," Optics Express, 16[8] (2008) 5710-5715

  201. N. Sadoni, B.-S. Targosz, A. Englmann, S. Fesser, J. Koch, D. Schindelhauer and D. Zink, "Transcription-Dependent Spatial Arrangements of CFTR and Conserved Adjacent Loci are Not Conserved in Human and Murine Nuclei," Chromosoma, 117[4] (2008) 381-397

  202. J. Corsi, M. K. Dymond, O. Ces, J. Muck, D. Zink and G. S. Attard, "DNA that is Dispersed in the Liquid Crystalline Phases of Phospholipids is Actively Transcribed," Chemical Communications, (2008) DOI: 10.1039/B801199K

  203. M. C. C. Lim, G. Maubach and L. Zhuo, "Glial Fibrillary Acidic Protein Splice Variants in Hepatic Stellate Cells - Expression and Regulation," Molecules and Cells, 25[3] (2008) 376-384

  204. H. L. Leo, A. W. L. Lim, X. Lei, D. M. Y. Ang, Z. Yue and H. Yu, "Development of a Perfusion-based Cellulosic Scaffold for In Vitro Drug Testing," Proceedings of the 3rd MRS-S Conference on Advanced Materials, (2008) DOI: -

  205. A. C. A. Wan, B. C. U. Tai, K. M. Schumacher, A. Schumacher, S. Y. Chin and J. Y. Ying, "Polyelectrolyte Complex Membranes for Specific Cell Adhesion," Langmuir, 24[6] (2008) 2611-2617

  206. Y. C. Toh, J. Zhang, Y. M. Khong, Y. Du, W. Sun and H. Yu, "Integrating Sensitive Quantification of Hepatic Metabolic Functions by Capillary Electrophoresis with Laser-Induced Fluorescence Detection," The Analyst, 133[3] (2008) 326-330

  207. D.-K. Chang, S.-F. Cheng, E. A. B. Kantchev, Y.-T. Liu and C.-H. Lin, "Membrane Interaction and Structure of the Transmembrane Domain of Influenza Hemagglutinin and its Fusion Peptide Complex," BMC Biology, 6[2] (2008)

  208. L. Xia, Y. Du, H. L. Leo and H. Yu, "The Relationship between Hepatocyte Density and Polarity in Synthetic Sandwich Culture," Proceedings of the International Conference on Advances in Bioresorbable Biomaterials for Tissue Engineering, (2008) DOI: -

  209. J. Zhou, J. Khng, J. V. Janakakumara, C. Bi, S. Neo, M. Pan, L. F. Poon, Z. Xie, H. Yu, E. J. Yeoh, Y. Lu, K. Glaser, D. Albert, S. K. Davidsen and C. S. Chen, "In Vivo Activity of ABT-869, a Multi-Target Kinase Inhibitor, AgainstAcuteMyeloid Leukemia withWild-Type FLT3 Receptor," Leukemia Research, 32[7] (2008) 1091-1100

  210. C. K. Sim and D. B. Forger, "Modeling the Electrophysiology of Suprachiasmatic Nucleus Neurons," Journal of Biological Rhythms, 22[5] (2007) 445-453

  211. Y. Du, R. Han, F. Wen, S. Ng, L. Xia, T. Wohland, H. L. Leo and H. Yu, "Synthetic Sandwich Culture of 3D Hepatocyte Monolayer," Biomaterials, 29[3] (2007) 290-301

  212. S. M. Ong, L. He, N. T. T. Linh, Y. H. Tee, T. Arooz, G. P. Tang, C. H. Tan and H. Yu, "Transient Inter-Cellular Polymeric Linker," Biomaterials, 28[25] (2007) 3656-3667

  213. Y. Du, R. B. Han, S. Ng, J. Ni, W. X. Sun, T. Wohland, S. H. Ong, L. Kuleshova and H. Yu, "Identification and Characterization of a Novel Pre-Spheroid 3D Hepatocyte Monolayer on Galactosylated Substratum," Tissue Engineering, 13[7] (2007) 1455-1468

  214. Y. N. Du, R. B. Han and H. Yu, "A Novel Synthetic Sandwich Configuration for Stabilizing and Culturing Pre-Spheroid Hepatocyte Monolayer," Proceedings of Keystone Symposium on "Tissue Engineering and Developmental Biology", (2007) DOI: -

  215. F. Wen, Y. M. Khong, Y. N. Du, Z. L. Yue, S. H. Teoh and H. Yu, "Surface Modification of Bulky Tissue Engineering Scaffold through Gamma Irradiation," Proceedings of Keystone Symposium on "Tissue Engineering and Developmental Biology", (2007) DOI: -

  216. S. M. Liu, L. Liu, Z. P. Xu, A. Yu, G. Q. Lu and J. C. D. da Costa, "Bioceramic Macrocapsules for Cell Immunoisolation," Angewandte Chemie International Edition, 46[17] (2007) 3062-3065

  217. S. M. Chia, F. Y. Kuan and H. Yu, "Thrombospondin-1 is a Key TGF-β1 Activator for Hepatic Stellate Cells in Liver Fibrosis," Proceedings of Keystone Symposium "Molecular Mechanisms in Fibrosis; From Bench to Bedside", (2007) DOI: -

  218. G. Maubach, M. C. C. Lim, S. Kumar and L. Zhuo, "Expression and Upregulation of Cathepsin S and Other Early Molecules Required for Antigen Presentation in Activated Hepatic Stellate Cells upon IFN-γ Treatment," Biochimica et Biophysica Acta - Molecular Cell Research, 1773[2] (2006) 219-231

  219. C. Y. Zhang and L. Zhuo, "EGCG and Genistein Attenuate GFAP Elevation Induced by Fibrogenic Cytokines in Hepatic Stellate Cells," International Journal of Molecular Medicine, 18[6] (2006) 1141-1151

  220. X. T. Pan, Y. C. Toh, H. Yu and T. Wohland, "Characterization of Poly(acrylic acid) Diffusion Dynamics on the Grafted Surface of Poly(ethylene Terephthalate) Films by Fluorescence Correlation Spectroscopy," Biophysical Review and Letters, 1[4] (2006) 433-441

  221. L. L. Ong, P. C. Lin, X. Zhang, S. M. Chia and H. Yu, "Kinectin-Dependent Assembly of Translation Elongation Factor-1 Complex on Endoplasmic Reticulum Regulates Protein Synthesis," Journal of Biological Chemistry, 281[44] (2006) 33621-33634

  222. E. K. F. Yim, A. C. A. Wan, C. Le Visage, I. C. Liao and K. W. Leong, "Proliferation and Differentiation of Human Mesenchymal Stem Cell in Polyelectrolyte Complexation Fibrous Scaffold," Biomaterials, 27[36] (2006) 6111-6122

  223. F. Wen, S. Chang, Y. C. Toh, S. H. Teoh and H. Yu, "Development of poly (lactic-co-glycolicacid)-collagenscaffolds for tissueengineering," Materials Science and Engineering, 27[2] (2006) 285-292

  224. S. M. Chia, C. M. Tan and H. Yu, "Novel Cell Culture Supplements for Enhanced Hepatocyte Functions," Proceedings of Regenerate World Congress on Tissue Engineering and Regenerative Medicine Pittsburgh, (2006) DOI: -

  225. A. C. A. Wan, B. C. U. Tai, K.-J. Leck and J. Y. Ying, "Silica-Incorporated Polyelectrolyte Complex Fibers as Tissue Engineering Scaffolds," Advanced Materials, 18[5] (2006) 641-644

  226. G. Maubach, M. C. C. Lim, C. Y. Zhang and L. Zhuo, "Glial Fibrillary Acidic Protein Promoter Directs lacZ Expression Specifically in a Rat Hepatic Stellate Cell Line," World Journal of Gastroenterology, 12[5] (2006) 723-730

  227. S. C. Wong, H. Yu and J. B. So, "Detection of Telomerase Activity in Gastric Lavage Fluid: A Novel Method to Detect Gastric Cancer," Journal of Surgical Research, 131[2] (2006) 252-255

  228. H. F. Lu, W. S. Lim, P. C. Zhang, S. M. Chia, H. Yu, H.-Q. Mao and K. W. Leong, "Galactosylated PVDF Hollow Fiber Bioreactor for Hepatocyte Culture," Tissue Engineering, 11[11-12] (2006) 1667-1677

  229. M. Lee and R. S. Ruan, "Malignant Transformation of Mammary Epithelial Cells under Prolonged Exposure to Oxidative Stress and Senescent Fibroblasts," Proceedings of the 2nd International Conference on Tumor Progression and Therapeutic Resistance, (2005) DOI: -

  230. F. Wen, S. Chang, Y. C. Toh, S. H. Teoh and H. Yu, "Preparation of Biocompatible Poly (lactic-co-glycolic acid) Fiber Scaffolds for Rat Liver Cells Cultivation," Materials Science and Engineering, (2005) DOI: -

  231. I. C. Liao, A. C. A. Wan, E. K. F. Yim and K. W. Leong, "Controlled Release from Fibers of Polyelectrolyte Complexes," Journal of Controlled Release, 104[2] (2005) 347-358

  232. Y. C. Toh, S. Ng, Y. M. Khong, V. Samper and H. Yu, "A Configurable 3D Microenvironment in a Micro-Fluidic Channel for Primary Hepatocytes Culture Assay and Drug Development," Technologies, 3[2] (2005) 169-176

  233. B. C. Heng, H. Yu, S. G. Lim, Y. J. Yin, and T. Cao, "Factors Influencing Stem Cell Differentiation into the Hepatic Lineage In Vitro," Journal of Gastroenterology and Hepatology, 20[7] (2005) 975-987

  234. Y. Zhou, T. Sun, M. Chan, J. Zhang, Z. Han, X. Wang, Y. Toh, J. P. Chen and H. Yu, "Scalable Encapsulation of Hepatocytes by Electrostatic Spraying," Journal of Biotechnology, 114 (2005) 99-109

  235. C. W. Tan and Y. Y. Yang, "pH-Triggered Thermally Responsive Polymer Core-Shell Nanoparticles for Targeted Drug Delivery," Advanced Materials, 17[3] (2005) 318-323

  236. Y. C. Toh, S. T. Ho, Y. Zhou, D. W. Hutmacher and H. Yu, "Application of Polyelectrolyte Complex Coacervation to Improve the Seeding Efficiency of Bone Marrow Stromal Cells in 3D Scaffolds," Biomaterials, 26[19] (2004) 4149-4160

  237. J. Zhang, H. P. Wei, C. H. Quek, S. M. Chia, and H. Yu, "Quantitative Measurement of Collagen Methylation by Capillary Electrophoresis," Electrophoresis, 25[20] (2004) 3416-3421

  238. S. S. S. Ng, Y. N. Wu, Y. Zhou, Y. E. Toh, Z. Z. Ho, S. M. Chia, J. H. Zhu, H. Q. Mao and H. Yu, "Optimization of 3-D Hepatocyte Culture by Controlling the Physical and Chemical Properties of the Extra-Cellular Matrices," Biomaterials, 26[16] (2005) 3153-3163

  239. N. Santama, P. N. Er, L. L. Ong, and H. Yu, "Kinectin Isoforms Exhibit Developmental, Cell-type and Organelle Specific Functions," Journal of Cell Sciences, 117[19] (2004) 4537-4549

  240. L. L. Kuleshova, X. W. Wang, Y. N. Wu, Y. Zhou and H. Yu, "Vitrification of Encapsulated Hepatocytes with Reduced Cooling/Warming Rates," Cryo Letters, 25[4] (2004) 241-254

  241. J. Wang, I. L. Lee, W. S. Lim, S. M. Chia, H. Yu, K. W. Leong, and H .Q. Mao, "Evaluation of Collagen and Methylated Collagen as Gene Carriers," International Journal of Pharmaceutics, 279[1-4] (2004) 115-126

  242. T. Sun, L. H. Chan, C. H. Quek and H. Yu, "Improving Mechanical Stability and Density Distribution of Hepatocyte Microcapsules by Fibrin Clot and Gold Nano-particles," Journal of Biotechnology, 111 (2004) 169-177

  243. A. C. A. Wan, H.-Q. Mao, S. Wang, S. H. Phua, G. P. Lee, J. H. Pan, S. Lu, J. Wang and K. W. Leong, "Poly(phosphoester) Ionomers as Tissue Engineering Scaffolds," Journal of Biomedical Materials Research, 70B (2004) 91-102

  244. C. H. Quek, J. Li, T. Sun, M. L. H. Chan, H. Q. Mao, L. M. Gan, K. W. Leong and H. Yu, "Photo-Crosslinkable Microcapsules Formed by Polyelectrolyte Copolymer and Modified Collagen with Enhanced Mechanical Strength and Cellular Functions for Rat Hepatocyte Encapsulation," Biomaterials, 25[17] (2004) 3531-3540

  245. B. C. Heng, H. Yu, and S. C. Ng, "Strategies for the Cryopreservation of Microencapsulated Cells," Biotechnology and Bioengineering, 85[2] (2003) 202-213

  246. T. Sun, L. H. Chan, Y. Zhou, X. Xu, J. Zhang, C. H. Quek, X. J. Lao, J. P. Chen, K. W. Leong, H. Yu, "The Use of Ultra-Thin Shell Microcapsules of Hepatocytes in a Bio-Artificial Liver-Assisted Device," Tissue Engineering, 9 Suppl 1 (2003) S65-75

  247. H. F. Lu, W. S. Lim, J. Wang, Z. Q. Tang, P. C. Zhang, K. W. Leong, S. M. Chia, H. Yu, and H.-Q. Mao, "Galactosylated PVDF Membrane Promotes Hepatocyte Attachment and Functional Maintenance," Biomaterials, 24[27] (2003) 4893-4903

  248. S. C. H. Wong, L. L. Ong, P. N. Er, S. J. Gao, H. Yu, and B. Y. So, "Cloning of Rat Telomerase Catalytic Subunit Functional Domains, Reconstitution of Telomerase Activity and Enzymatic Profile of Pig and Chicken Tissues," Life Sciences, 73[21] (2003) 2749-2760

  249. C. Iliescu, J. Miao and F. E. H. Tay, "Optimization of PECVD Amorphous Silicon Process for Deep Wet Etching of Pyrex Glass," Surface Coatings Technology, (2003) DOI: -

  250. L. L. Ong, A. Ho, P. N. Er, H. Yu, "Kinectin Anchors Eukaryotic Elongation Factor, Delta to Endoplasmic Reticulum," Journal of Biological Chemistry, 278[34] (2003) 32115-32123

  251. S. C. H. Wong, H. Yu, S. M. Moochhala, and B. Y. So, "Antisense Telomerase Induced Cell Growth Inhibition, Cell Cycle Arrest and Telomerase Activity Down-Regulation in Gastric and Colon Cancer Cells," Anticancer Research, 23[1A] (2003) 465-469

  252. X. Y. Xu, W. C. Yee, P. Y. K. Hwang, H. Yu, A. C. A. Wan, S. J. Gao, K. L. Boon, H. Q. Mao, K. W. Leong, and S. Wang, "Peripheral Nerve Regeneration with Sustained Release of Poly(phosphoester) Microencapsulated Nerve Growth Factor within Nerve Guide Conduits," Biomaterials, 24[13] (2003) 2405-2412

  253. C. Yin, S. M. Chia, C. H. Quek, H. Yu, R. X. Zhuo, K. W. Leong, H. Q. Mao, "Microcapsules With Improved Mechanical Stability For Hepatocyte Culture," Biomaterials, 24[10] (2003) 1771-1780

Research Staff

YING Jackie Yi-Ru, Executive Director

YU Hanry, Group Leader

SUN William, Team Leader and Principal Research Scientist

WAN Chwee Aun Andrew, Team Leader and Principal Research Scientist

ZINK Daniele, Team Leader and Principal Research Scientist


23 Jan
IBN Seminar Series: Conformational Communication: Design and Synthesis of Membrane-Bound Receptor Mimics by Prof. Jonathan Clayden, University of Bristol, UK

Event Calendar   


Graphene Oxide-Templated Synthesis of Ternary Oxide Nanosheets for High Performance Li-ion Battery Anodes
Nano Energy, 44 (2018) 399-410.
(IF: 12.343) article

Hexaazatrinaphthylene-Based Porous Organic Polymers as Organic Cathode Materials for Lithium Ion Battery
ACS Sustainable Chemistry and Engineering, (2017)
DOI: 10.1021/acssuschemeng.7b03165.
(IF: 5.951) article

Highly Efficient Gas Phase Oxidation of Renewable Furfural to Maleic Anhydride over Plate VPO Catalyst
ChemSusChem, (2017)
DOI: 10.1002/cssc.201701866.
(IF: 7.226) article



Research Positions

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