A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

RESEARCH AREAS > Nanomedicine

Nanomedicine

Nanomedicine, where functionalized polymers, hydrogels and biologics are developed as therapeutics and carriers for the controlled release and targeted delivery of medication to diseased cells and organs.

View research projects, research publications and research staff in this research area.

Research Projects

1. Antiviral Polymers with Broad-Spectrum Activity, High Selectivity and Resistance Mitigation

Chuan Yang, Shujun Gao and Yi Yan Yang

Treatment of viral infections continues to be challenging due to the variance in viral structure (RNA, DNA, enveloped and non-enveloped viruses) and their ability to rapidly mutate and garner resistance. We have developed a general strategy to prevent viral infection using multi-functional macromolecules that were designed to have mannose moieties that compete with viruses for immune cells, and basic amine groups that block viral entry through electrostatic interactions and prevent viral replication by neutralizing the endosomal pH. These macromolecules effectively prevented dengue, influenza, Chikungunya, Enterovirus 71, Ebola, Marburg and herpes simplex infections at polymer concentrations as low as 0.2 mg/L with very high selectivity (> 5000) over mammalian cells. As the antiviral mechanism is based on non-specific supramolecular interactions between the amino acid residues and mannose/cationic moieties of the macromolecule, repeated use of the molecules did not induce drug resistance development. These macromolecules are being tested for in vivo efficacy.

2. CAR-Grafted Immune Cell Therapeutics for Cancer Immunotherapy

Jieming Zeng, Lai Ling Toh and Shu Wang

Chimeric antigen receptor (CAR)-modified immune cell therapy has achieved a significant advance in combating blood cancer and is highly promising for the treatment of solid tumors. Since CAR-grafted alpha beta T-cells concurrently express endogenous T cell receptors (TCRs) in the same T cells, uncontrolled graft-versus-host effects may be produced when used allogeneically. We aim to develop off-the-shelf, allogeneic CAR-grafted, anti-cancer cell therapeutics and focus on natural killer (NK) cells and gamma delta T-cells. Our goal is to translate the research findings in the laboratory into clinical products that can benefit patients.

3. Injectable Biodegradable Hydrogels for Drug Delivery and Tissue Engineering

Fan Lee, Ki Hyun Bae, Atsushi Yamashita, Chixuan Liu, Li Li, Shengyong Ng, Susi Tan, Joo Eun Chung and Motoichi Kurisawa

Hydrogels are soft materials with high water content. IBN researchers have developed a novel gel that can encapsulate therapeutic proteins, growth factors and cells for drug delivery and tissue regeneration. The hydrogels are biodegradable, made of non-toxic materials and can be injected into the body. They can regulate the rate of drug release in the body over a specific period, and reduce the need for frequent injections. These new materials show tremendous potential for improved treatment of cancer and neurological disorders. They can also be used as a scaffold to grow new tissues.

4. Inorganic Nanomaterials for Antimicrobial Applications

Guangshun Yi, Yuan Yuan, Xiukai Li, Hong Wu, Jackie Y. Ying and Yugen Zhang

IBN has developed inorganic and non-toxic antimicrobial materials specifically for surface disinfection and consumer care applications. Our antimicrobial technologies kill microbes either by physically rupturing their cell membranes or by radical killing mechanism, which prevents the microbes from developing drug resistance and mutating into superbugs. The nanomaterials are low-cost, environmentally friendly and safe. They are effective against a wide range of microbes and would be a powerful weapon against superbugs.

5. Macromolecular Antimicrobials to Combat Microbes

Chuan Yang, Shrinivas Venkataraman, Xin Ding, Shaoqiong Liu, Jeremy Tan, David Voo, Zhen Chang Liang, Eddy Tan, Shujun Gao, Yuan Yuan, Diane Lim, Hong Wu, Jackie Y. Ying, Yugen Zhang and Yi Yan Yang

The increasing prevalence of antibiotic-resistant infections, such as Methicillin-resistant Staphylococcus aureus (MRSA), has sparked off a pressing need for innovative antimicrobial treatments. IBN has developed a new class of antimicrobial polymers and peptides that can provide a new arsenal against superbugs. Most modern-day antibiotics act on specific molecular targets within the bacteria. While this yields therapeutic specificity, it also allows resistance development through mutation since the bacterial cell structure is generally preserved. The antimicrobial macromolecules are biodegradable and biocompatible, and have broad-spectrum antimicrobial activities against bacteria, yeast and fungi, to destroy multidrug-resistant microbes and prevent drug resistance development.

6. Polymeric Nanoparticles for Targeted Drug Delivery towards Cancer Cells and Cancer Stem Cells

Shaoqiong Liu, Ashlynn Lee, Chuan Yang, Nor Lizawati Ibrahim, Shujun Gao and Yi Yan Yang

We aim to develop safe polymer-based nanocarriers with narrow size distribution, high drug loading capacity and in vivo stability to transport small molecular anti-cancer drugs to cancer cells and cancer stem cells that are responsible for tumor relapse and metastasis. Biodegradable polymer nanoparticles that can interact with the drugs have been synthesized. A number of platform technologies have been developed to deliver a variety of drugs, proteins and genes. In particular, the co-delivery of dual drugs has been demonstrated to effectively suppress tumor growth by eliminating both cancer cells and cancer stem cells. These co-delivery nanosized formulations have the potential to improve cancer therapy, and prevent relapse and metastasis.

7. Using Green Tea Nanocomplex to Fight Cancer

Joo Eun Chung, Susi Tan, Kun Liang, Nunnarpas Yongvongsoontorn, Atsushi Yamashita, Li Li, Shengyong Ng, Shujun Gao, Lucky Swarnalatha Sasidharan, Rachel Sim, Min-Han Tan, Motoichi Kurisawa and Jackie Y. Ying

Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. IBN has taken the health benefits of green tea to the next level by using one of its key compounds, epigallocatechin gallate (EGCG), to develop micellar nanocomplexes for delivering anti-cancer protein drugs. The nanocarrier is formed by complexation of oligomerized EGCG with the protein drugs to form the core, followed by complexation of poly(ethylene glycol)–EGCG to form the shell. The micellar nanocomplexes protect the protein drugs from rapid proteolysis and renal clearance, while providing for tumor targeting. This green tea nanocarrier reduces tumor growth more effectively than using the drug by itself. We are also exploring the delivery of active ingredients in personal care and nutritional products using the micellar nanocomplexes.

Research Publications

  1. K. H. Bae, S. Tan, A. Yamashita, W. X. Ang, S. Gao, S. Wang, J. E. Chung and M. Kurisawa, "Hyaluronic Acid-Green Tea Catechin Micellar Nanocomplex: Fail-Safe Cisplatin Nanomedicine for the Treatment of Ovarian Cancer Without Off-Target Toxicity," Biomaterials, (2017) DOI: 10.1016/j.biomaterials.2017.09.027

  2. C. Liu, K. H. Bae, A. Yamashita, J. E. Chung and M. Kurisawa, "Thiol-Mediated Synthesis of Hyaluronic Acid-Epigallocatechin-3-O-Gallate Conjugates for the Formation of Injectable Hydrogels with Free Radical Scavenging Property and Degradation Resistance," Biomacromolecules, 18 (2017) 3143-3155

  3. J. P. K. Tan, D. J. Coady, H. Sardon, A. Yuen, S. Gao, S. W. Lim, Z. C. Liang, E. W. Tan, S. Venkataraman, A. C. Engler, M. Fevre, R. On, Y. Y. Yang and J. L. Hedrick, "Broad Spectrum Macromolecular Antimicrobials with Biofilm Disruption Capability and In Vivo Efficacy," Advanced Healthcare Materials, (2017) DOI: 10.1002/adhm.201601420

  4. Y. Yuan and Y. Zhang, "Enhanced Biomimic Bactericidal Surfaces by Coating with 2 Positively-Charged ZIF Nano-Dagger Arrays," Nanomedicine: Nanotechnology, Biology and Medicine, (2017) DOI: 10.1016/j.nano.2017.06.003

  5. J. S. Khara, S. Obuobi, Y. Wang, M. S. Hamilton, B. D. Robertson, S. M. Newton, Y. Y. Yang, P. R. Langford and P. L. R. Ee, "Disruption of Drug-Resistant Biofilms Using De Novo Designed Short α-Helical Antimicrobial Peptides with Idealized Facial Amphiphilicity," Acta Biomaterialia, 57 (2017) 103-114

  6. Z. Y. Ong, C. Yang, W. Cheng, Z. X. Voo, W.Chin, J. L. Hedrick and Y. Yan Yang, "Biodegradable Cationic Poly(carbonates): Effect of Varying Side Chain Hydrophobicity on Key Aspects of Gene Transfection," Acta Biomaterialia, (2017) DOI: 10.1016/j.actbio.2017.03.027

  7. S. Liu, R. J. Ono, H. Wu, J. Y. Teo, Z. C. Liang, K. Xu, M. Zhang, G. Zhong, J. P.K. Tan, M. Ng, C. Yang, J. Chan, Z. Ji, C. Bao, K. Kumar, S. Gao, A. Lee, M. Fevre, H. Dong, J. Y. Ying, L. Li, W. Fan, J. L. Hedrick and Y. Y. Yang, "Highly Potent Antimicrobial Polyionenes with Rapid Killing Kinetics, Skin Biocompatibility and In Vivo Bactericidal Activity," Biomaterials, 127 (2017) 36-48

  8. N. H. Park, Z. X. Voo, Y. Y. Yang and J. L. Hedrick, "Convergent Approach to Boronic Acid Functionalized Polycarbonates: Accessing New Dynamic Material Platforms," ACS Macro Letters, 6[3] (2017) 252-256

  9. A. Bossion, G. O. Jones, D. Taton, D. Mecerreyes, J. L. Hedrick, Z. Y. Ong, Y. Y. Yang and H. Sardon, "Non-Isocyanate Polyurethane Soft Nanoparticles Obtained by Surfactant-Assisted Interfacial Polymerization," Langmuir, 33[8] (2017) 1959-1968

  10. J. M. W. Chan, R. J. Wojtecki, H. Sardon, A. L. Z. Lee, C. E. Smith, A. Shkumatov, S. Gao, H. Kong, Y. Y. Yang and J. L. Hedrick, "Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers," ACS Macro Letters, 6[2] (2017) 176-180

  11. G. Zhong, J. Cheng, Z. C. Liang, L. Xu, W. Lou, C. Bao, Z. Y. Ong, H. Dong, Y. Y. Yang and W. Fan, "Short Synthetic β-Sheet Antimicrobial Peptides for the Treatment of Multidrug-Resistant Pseudomonas Aeruginosa Burn Wound Infections," Advanced Healthcare Materials, 6 (2017) 1601134

  12. H. Wu, S. Liu, N. Wiradharma, Z. Y. Ong, Y. Li, Y. Y. Yang and J. Y. Ying, "Short Synthetic α-Helical-Forming Peptide Amphiphiles for Fungal Keratitis Treatment In Vivo," Advanced Healthcare Materials, (2017) DOI: 10.1002/adhm.201600777

  13. W. X. Ang, Z. Li, Z. Chi, S.-H. Du, C. Chen, J. C. K. Tay, H. C. Toh, J. E. Connolly, X. H. Xu and S. Wang, "Intraperitoneal Immunotherapy with T Cells Stably and Transiently Expressing Anti-EpCAM CAR in Xenograft Models of Peritoneal Carcinomatosis," Oncotarget, 8 (2017) 13545-13559

  14. S. Venkataraman, J. P. K. Tan, V. W. L. Ng, E. W. P. Tan, J. L. Hedrick and Y. Y. Yang, "Amphiphilic and Hydrophilic Block Copolymers from Aliphatic N-Substituted 8-Membered Cyclic Carbonates: A Versatile Macromolecular Platform for Biomedical Applications," Biomacromolecules, 18 (2016) 178-188

  15. Y. Zu, M. H. Tan, E. C. Ren and J. Y. Ying, "Facile and Phase-Defined Determination of HLA Alleles with Morpholino-Functionalized Nanoparticle Probes," Nanomedicine, (2016) DOI: 10.1016/j.nano.2016.09.009

  16. P. Yuan, X. Ding, N. Gao, H. Zhu, Y. Y. Yang and Q. H. Xua, "Au-Ag Core-Shell Nanoparticles for Simultaneous Bacterial Imaging and Synergistic Antibacterial Activity," Nanomedicine: Nanotechnology, Biology and Medicine, (2016) DOI: 10.1016/j.nano.2016.09.003

  17. Y. S. Pek, H. Wu, S. T. Mohamed, and J. Y. Ying, "Long-Term Subconjunctival Delivery of Brimonidine Tartrate for Glaucoma Treatment Using a Microspheres/Carrier System," Advanced Healthcare Materials, (2016) DOI: 10.1002/adhm.201600780

  18. C. Englert, M. Fevre, R. J. Wojtecki, W. Cheng, Q. Xu, C. Yang, X. Ke, M. Hartlieb, K. Kempe, J. M. GarcĂ­a, R. J. Ono, U. S. Schubert, Y. Y. Yang and J. L. Hedrick, "Facile Carbohydrate-Mimetic Modifications of Poly(ethylene imine) Carriers for Gene Delivery Applications," Polymer Chemistry, 7 (2016) 5862-5872

  19. Y. S. Pek, H. Wu, E. P. Y. Chow and J. Y. Ying, "Transparent Nanostructured Photochromic UV-Blocking Soft Contact Lenses," Nanomedicine, 11[12] (2016) 1599-1610

  20. J. S. Khara, M. Priestman, I. UhĂ­a, M. S. Hamilton, N. Krishnan, Y. Wang, Y. Y. Yang, P. R. Langford, S. M. Newton, B. D. Robertson and P. L. Ee, "Unnatural Amino Acid Analogues of Membrane-Active Helical Peptides with Anti-Mycobacterial Activity and Improved Stability," Journal of Antimicrobial Chemotherapy, 71 (2016) 2181-2191

  21. C. Yang, S. Krishnamurthy, J. Liu, S. Liu, X. Lu, D. J. Coady, W. Cheng, G. D. Libero, A. Singhal, J. L. Hedrick and Y. Y. Yang, "Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells," Advanced Healthcare Materials, 5[11] (2016) 1272-1281

  22. K. Ichiyama, C. Yang, L. Chandrasekaran, S. Liu, L. Rong, Y. Zhao, S. Gao, A. Lee, K. Ohba, Y. Suzuki, Y. Yoshinaka, K. Shimotohno, K. Miyakawa, A. Ryo, J. Hedrick, N. Yamamoto and Y. Y. Yang, "Cooperative Orthogonal Macromolecular Assemblies with Broad Spectrum Antiviral Activity, High Selectivity, and Resistance Mitigation," Macromolecules, (2016) DOI: 10.1021/acs.macromol.6b00091

  23. J. M. W. Chan J. P. K. Tan, A. C. Engler, X. Ke, S. Gao, C. Yang, H. Sardon, Y. Y. Yang and J. L. Hedrick, "Organocatalytic Anticancer Drug Loading of Degradable Polymeric Mixed Micelles via a Biomimetic Mechanism," Macromolecules, (2016) DOI: 10.1021/acs.macromol.5b02784

  24. Q. Xu, C. Yang, J. L. Hedrick and Y. Y. Yang, "Antimicrobial Silica Particles Synthesized via Ring-Opening Grafting of Cationic Amphiphilic Cyclic Carbonates: Effects of Hydrophobicity and Structure," Polymer Chemistry, (2016) DOI: 10.1039/c6py00194g

  25. K. Liang, K. H. Bae, F. Lee, K. Xu, J. E. Chung, S. J. Gao and M. Kurisawa, "Self-Assembled Ternary Complexes Stabilized with Hyaluronic Acid-Green Tea Catechin Conjugates for Targeted Gene Delivery," Journal of Controlled Release, 226 (2016) 205-216

  26. K. Liang, S. Ng, F. Lee, J. Lim, J. E. Chung, S. S. Lee and M. Kurisawa, "Targeted Intracellular Protein Delivery Based on Hyaluronic Acid–Green Tea Catechin Nanogels," Acta Biomaterialia, 33 (2016) 142-152

  27. Z. X. Voo, M. Khan, Q. Xu, K. Narayanan, B. W. J. Ng, R. B. Ahmad, J. L. Hedrick and Y. Y. Yang, "Antimicrobial Coatings Against Biofilm Formation: The Unexpected Balance Between Antifouling and Bactericidal Behaviour," Polymer Chemistry, 7 (2015) 656-668

  28. P. Y. Teo. W. Cheng, J. L. Hedrick, Y. Y. Yang, "Co-Delivery of Drugs and Plasmid DNA for Cancer Therapy," Advanced Drug Delivery Reviews, (2015) DOI: 10.1016/j.addr.2015.10.014

  29. J.Zeng, C. Wu and S. Wang, "Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells," Scientific Reports, (2015) DOI: 10.1038/srep15262

  30. S. Venkataraman, V. W. L. Ng, D. J. Coady, H. W. Horn, G. O Jones, T. S. Fung, H. SardĂłn, R. M. Waymouth, J. L. Hedrick and Y. Y. Yang, "A Simple and Facile Approach to Aliphatic N-substituted Functional Eight-Membered Cyclic Carbonates and Their Organo-catalytic Polymerization," Journal of the American Chemical Society, (2015) DOI: 10.1021/jacs.5b06355

  31. Y. Luo, D. Zhu, D. H. Lam, J. Huang, Y. Tang, X. Luo and S. Wang, "A Double-Switch Cell Fusion-Inducible Transgene Expression System for Neural Stem Cell-Based Antiglioma Gene Therapy," Stem Cells International, (2015) DOI: 10.1155/2015/649080

  32. V. M. Prabhu, S. Venkataraman, Y. Y. Yang and J. L. Hedrick, "Equilibrium Self-Assembly, Structure, and Dynamics of Clusters of Star-Like Micelles," ACS Macro Letters, 4 (2015) 1128-1133

  33. J. S. Khara, F. K. Lim, Y. Wanga, X. Ke, Z. X. Voo, Y. Y. Yang, R. Lakshminarayanan, P. L. R. Ee, "Designing α-Helical Peptides with Enhanced Synergism and Selectivity Against Mycobacterium Smegmatis: Discerning the Role of Hydrophobicity and Helicity," Acta Biomaterialia, (2015) DOI: 10.1016/j.actbio.2015.09.015

  34. S. Krishnamurthy, V. W. L. Ng, S. Gao, M. H. Tan, J. L. Hedrick and Y. Y. Yang, "Codelivery of Dual Drugs from Polymeric Micelles for Simultaneous Targeting of Both Cancer Cells and Cancer Stem Cells," Nanomedicine, 10 (2015) 2819-2832

  35. J. Cheng, W. Chin, H. Dong, L. Xu, G. Zhong, Y. Huang, L. Li, K. Xu, M. Wu, J. L. Hedrick, Y. Y. Yang and W. Fan, "Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy Against Multidrug-Resistant MRSA Systemic Infection," Advanced Healthcare Materials, (2015) DOI: 10.1002/adhm.201500471

  36. Z. Yu, Q. Xu, C. B. Dong, S. S. Lee, L. Gao ,Y. Li, M. D'Ortenzio and J. Wu, "Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform," Current Pharmaceutical Design, 21[29] (2015) 4342-4354

  37. F. Lee, J. E. Chung, K. Xu and M. Kurisawa, "Injectable Degradation-Resistant Hyaluronic Acid Hydrogels Cross-Linked via the Oxidative Coupling of Green Tea Catechin," ACS Macro Letters, 4 (2015) 957-960

  38. H. Sardon, J. P. Tan, J. M. Chan, D. Mantione, D. Mecerreyes, J. L. Hedrick and Y. Y. Yang, "Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery," Macromolecular Rapid Communications, 36[19] (2015) 1761-1767

  39. R. J. Ono, A. L. Z. Lee, W. Chin, W. S. Goh, A. Y. L. Lee, Y. Y. Yang and J. L. Hedrick, "Biodegradable Block Copolyelectrolyte Hydrogels for Tunable Release of Therapeutics and Topical Antimicrobial Skin Treatment," ACS Macro Letters, 4 (2015) 886-891

  40. K. Xu, F. Lee, S. Gao, M.-H. Tan and M. Kurisawa, "Hyaluronidase-Incorporated Hyaluronic Acid-Tyramine Hydrogels for the Sustained Release of Trastuzumab," Journal of Controlled Release, 216 (2015) 47–55

  41. K. Xu, F. Lee, S. Gao, M. H. Tan and M. Kurisawa, "Hyaluronidase-Incorporated Hyaluronic Acid–Tyramine Hydrogels for the Sustained Release of Trastuzumab," Journal of Controlled Release, (2015) DOI: 10.1016/j.jconrel.2015.08.015

  42. C. A. E. Hauser, Y. Loo, A. Lakshmanan, M. Ni, L. L. Toh, and S. Wang, "Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for 3D Organotypic Cultures," Nano Letters, (2015) DOI: 10.1021/acs.nanolett.5b02859

  43. A. L. Z. Lee, S. Venkataraman, C. H. Fox, D. J. Coady, C. W. Frank, J. L. Hedrick and Y. Y. Yang, "Modular Composite Hydrogels from Cholesterol-Functionalized Polycarbonates for Antimicrobial Applications," Journal of Materials Chemistry B, 3 (2015) 6953-6963

  44. J. H. Soh, Y. Lin, S. Rana, J. Y. Ying and M. M. Stevens, "Colorimetric Detection of Small Molecules in Complex Matrixes via Target-Mediated Growth of Aptamer-Functionalized Gold Nanoparticles," Analytical Chemistry, (2015) DOI: 10.1021/acs.analchem.5b00875

  45. K. Xu, K. Narayanan, F. Lee, K. H. Bae, S. Gao and M. Kurisawa, "Enzyme-Mediated Hyaluronic Acid–Tyramine Hydrogels for the Propagation of Human Embryonic Stem Cells in 3D," Acta Biomaterialia, (2015) DOI: 10.1016/j.actbio.2015.06.026

  46. K. H. Bae, F. Lee, K. Xu, C. T. Keng, S. Y. Tan, Y. J. Tan, Q. Chen and M. Kurisawa, "Microstructured Dextran Hydrogels for Burst-Free Sustained Release of PEGylated Protein Drugs," Biomaterials, (2015) DOI: 10.1016/j.biomaterials.2015.06.008

  47. W. Cheng, C. Yang, X. Ding, A. C. Engler, J. L. Hedrick and Y. Y. Yang, "Broad-Spectrum Antimicrobial/Antifouling Soft Material Coatings Using Poly(ethylenimine) as a Tailorable Scaffold," Biomacromolecules, (2015) DOI: 10.1021/acs.biomac.5b00359

  48. C. D. Ren, M. Kurisawa, J. E. Chung and J. Y. Ying, "Liposomal Delivery of Horseradish Peroxidase for Thermally Triggered Injectable Hyaluronic Acid-Tyramine Hydrogel Scaffold," Journal of Materials Chemistry B, 3[23] (2015) 4663-4670

  49. S. George, S. S. Ho, E. S. P. Wong, T. T. Y. Tan, M. K. Verma, R. J. Aitken, M. Riediker, C. Cummings, L. Yu, Z. M. Wang, D. Zink, Z. Ng, S. C. J. Loo, and K. W. Ng, "The Multi-Facets of Sustainable Nanotechnology – Lessons from a Nanosafety Symposium," Nanotoxicology, 9 (2015) 404-406

  50. F. Lee, J. Lim, M. R. Reithofer, S. S. Lee, J. E. Chung, C. A. E. Hauser and M. Kurisawa, "Synthesis and Bioactivity of a Conjugate Composed of Green Tea Catechins and Hyaluronic Acid," Polymer Chemistry, 6 (2015) 4462-4472

  51. P. Y. Teo, C. Yang, L. M. Whilding, A. C. Parente-Pereira, J. Maher, A. J. George, J. L. Hedrick, Y. Y. Yang and S. Ghaem-Maghami, "Ovarian Cancer Immunotherapy Using PD-L1 siRNA Targeted Delivery from Folic Acid-Functionalized Polyethylenimine: Strategies to Enhance T Cell Killing," Advanced Healthcare Materials, 4 (2015) 1180-1189

  52. C. Yang, S. Q. Liu, S. Venkataraman, S. J. Gao, X. Y. Ke, X. T. Chia, J. L. Hedrick and Y. Y. Yang, "Structure-Directing Star-Shaped Block Copolymers: Supramolecular Vesicles for the Delivery of Anticancer Drugs," Journal of Controlled Release, (2015) DOI: 10.1016/j.jconrel.2015.03.027

  53. A. Pascual, J. P. K. Tan, A. Y. Yuen, J. M. W. Chan, D. J. Coady, D. Mecerreyes, J. L. Hedrick, Y. Y. Yang and H. SardĂłn, "Broad-Spectrum Antimicrobial Polycarbonate Hydrogels with Fast Degradability," Biomacromolecules, (2015) DOI: DOI: 10.1021/bm501836z

  54. A. C. Engler, X. Ke, S. Gao, J. M. W. Chan, D. J. Coady, R. J. Ono, R. Lubbers, A. Nelson, Y. Y. Yang and J. L. Hedrick, "Hydrophilic Polycarbonates: Promising Degradable Alternatives to Poly(ethylene glycol)-Based Stealth Materials," Macromolecules, (2015) DOI: 10.1021/acs.macromol.5b00156

  55. S. Tan, C. Gan, R. Li, Y. Ye, S. Zhang, X. Wu, Y. Y. Yang, W. Fan and M. Wu, "A Novel Chemosynthetic Peptide with β-Sheet Motif Efficiently Kills Klebsiella Pneumoniae in a Mouse Model," International Journal of Nanomedicine, 10 (2015) 1045-1059

  56. Z. X. Voo, M. Khan, K. Narayanan, D. Seah, J. L. Hedrick, and Y. Y. Yang, "Antimicrobial/Antifouling Polycarbonate Coatings: Role of Block Copolymer Architecture," Macromolecules, (2015) DOI: 10.1021/ma5022488

  57. A. L. Z. Lee, V. W. L. Ng, S. Gao, J. L. Hedrick and Y. Y. Yang, "Injectable Biodegradable Hydrogels from Vitamin D‑Functionalized Polycarbonates for the Delivery of Avastin with Enhanced Therapeutic Efficiency Against Metastatic Colorectal Cancer," Biomacromolecules, (2015) DOI: 10.1021/bm5015206

  58. X. Liu, H. Li, L. Wu, J. Xing, Y. Poh, H. Cai and B. C. Cai, "Simultaneous Quantification of Chrysophanol and Physcion in Rat Plasma by Ultra Fast Liquid Chromatography-Tandem Mass Spectrometry and Application of the Technique to Comparative Pharmacokinetic Studies of Radix et Rhei Rhizoma Extract Alone and Dahuang Fuzi Decoction," Journal of Chromatography B, 980 (2015) 88-93

  59. S. H. Du, J. C. Tay, C. Chen, F. C. Tay, W. K. Tan, Z. D. Li and S. Wang, "Human iPS Cell-Derived Fibroblast-Like Cells as Feeder Layers for iPS Cell Derivation and Expansion," Journal of Bioscience and Bioengineering, (2015) DOI: 10.1016/j.jbiosc.2014.12.009

  60. Q. Xu, H. Sardon, J. M. W. Chan, J. L. Hedrick and Y. Y. Yang, "Polyurethane-Coated Silica Particles with Broad-Spectrum Antibacterial Properties," Polymer Chemistry, (2015) DOI: 10.1039/C4PY01455C

  61. S. Krishnamurthy, X. Ke and Y. Y. Yang, "Delivery of Therapeutics Using Nanocarriers for Targeting Cancer Cells and Cancer Stem Cells," Nanomedicine, 10[1] (2015) 143-160

  62. A. L. Z. Lee, V. W. L. Ng, S. Gao, J. L. Hedrick and Y. Y. Yang, "Injectable Biodegradable Hydrogels from Vitamin D-Functionalized Polycarbonates for the Delivery of Avastin with Enhanced Therapeutic Efficiency against Metastatic Colorectal Cancer," Biomacromolecules, (2014) DOI: 10.1021/bm5015206

  63. H. Wu, Z. Y. Ong, S. Liu, Y. Li, N. Wiradharma, Y. Y. Yang and J. Y. Ying, "Synthetic β-Sheet Forming Peptide Amphiphiles for Treatment of Fungal Keratitis," Biomaterials, 43 (2014) 44-49

  64. P. Yuan, X. Ding, Z. Guan, N. Gao, R. Ma, X. F. Jiang, Y. Y. Yang and Q. H. Xu, "Plasmon-Coupled Gold Nanospheres for Two-Photon Imaging and Photoantibacterial Activity," Advanced Healthcare Materials, 4[5] (2014) 674-678

  65. R. J. Ono, S. Liu, S. Venkataraman, W. Chin, Y. Y. Yang and J. L. Hedrick, "Benzyl Chloride-Functionalized Polycarbonates: A Versatile Platform for the Synthesis of Functional Biodegradable Polycarbonates," Macromolecules, (2014) DOI: 10.1021/ma501734y

  66. V. W.L. Ng, J. M.W. Chan, H. Sardon, R. J. Ono, J. M. GarcĂ­a, Y. Y. Yang and J. L. Hedrick, "Antimicrobial Hydrogels: A New Weapon in the Arsenal Against Multidrug-Resistant Infections," Advanced Drug Delivery Reviews, 78 (2014) 46-62

  67. J. E. Chung, S. Tan, S. J. Gao, N. Yongvongsoontorn, S. H. Kim, J. H. Lee, H. S. Choi, H. Yano, L. Zhuo, M. Kurisawa and J. Y. Ying, "Self-Assembled Micellar Nanocomplexes Comprising Green Tea Catechin Derivatives and Protein Drugs for Cancer Therapy," Nature Nanotechnology, 9 (2014) 907-912

  68. C. Yang, X. Ding, R. J. Ono, H. Lee, L. Y. Hsu, Y. W. Tong, J. Hedrick and Y. Y. Yang, "Brush-Like Polycarbonates Containing Dopamine, Cations, and PEG Providing a Broad-Spectrum, Antibacterial, and Antifouling Surface via One-Step Coating," Advanced Materials, (2014) DOI: 10.1002/adma.201402059

  69. Y. S. Pek, P. Pitukmanorom and J. Y. Ying, "Sustained Release of Bupivacaine for Post-Surgical Pain Relief Using Core–Shell Microspheres," Journal of Materials Chemistry B, (2014) DOI: 10.1039/C4TB00948G

  70. S. Krishnamurthy, V. W.L. Ng, S. Gao, M. H. Tan and Y. Y. Yang, "Phenformin-Loaded Polymeric Micelles for Targeting Both Cancer Cells and Cancer Stem Cells In Vitro and In Vivo," Biomaterials, 35[33] (2014) 9177-9186

  71. A. B. E. Attia, P. Oh, C. Yang, J. P. K. Tan, N. Rao, J. L. Hedrick, Y. Y. Yang and R. Ge, "Insights into EPR Effect versus Lectin-Mediated Targeted Delivery: Biodegradable Polycarbonate Micellar Nanoparticles With and Without Galactose Surface Decoration," Small, (2014) DOI: 10.1002/smll.201401295

  72. X. Ke, V. W. L. Ng, R. J. Ono, J. M.W. Chan, S. Krishnamurthy, Y. Wang, J. L. Hedrick and Y. Y. Yang, "Role of Non-Covalent and Covalent Interactions in Cargo Loading Capacity and Stability of Polymeric Micelles," Journal of Controlled Release, (2014) DOI: 10.1016/j.jconrel.2014.06.061

  73. S. Q. Liu, S. Venkataraman, Z. Y. Ong, J. M. W. Chan, C. Yang, J. L. Hedrick and Y. Y. Yang, "Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers," Small, 10[20] (2014) 4130-4135

  74. J. M. W. Chan, X. Ke, H. Sardon,A. C. Engler, Y. Y. Yang and J. L. Hedrick, "Chemically Modifiable N-heterocyclefunctionalized Polycarbonates as a Platform for Diverse Smart Biomimetic Nanomaterials," Chemical Science, 5 (2014) 3294-3300

  75. F. C. Tay, J. K. Lim, H. Zhua, L. C. Hin and S. Wang, "Using Artificial MicroRNA Sponges to Achieve MicroRNA Loss-of-Function in Cancer Cells," Advanced Drug Delivery Reviews, (2014) DOI: 10.1016/j.addr.2014.05.010

  76. L. S. Wang, F. Lee, J. Lim, C. Du, A.C.A. Wan, S. S. Lee and M. Kurisawa, "Enzymatic Conjugation of a Bioactive Peptide into an Injectable Hyaluronic Acid–Tyramine Hydrogel System to Promote the Formation of Functional Vasculature," Acta Biomaterialia, (2014) DOI: 10.1016/j.actbio.2014.02.022

  77. V. W. L. Ng, J. P. K. Tan, J. Leong, Z. X. Voo, J. L. Hedrick and Y. Y. Yang, "Antimicrobial Polycarbonates: Investigating the Impact of Nitrogen-Containing Heterocycles as Quaternizing Agents," Macromolecules, (2014) DOI: 10.1021/ma402641p

  78. X. Ke, D. J. Coady, C. Yang, A. C. Engler, J. L. Hedrick and Y. Y. Yang, "pH-Sensitive Polycarbonate Micelles for Enhanced Intracellular Release of Anticancer Drugs: A Strategy to Circumvent Multidrug Resistance," Polymer Chemistry, (2014) DOI: 10.1039/C3PY01784B

  79. Y. Wang, X. Ke, J. S. Khara, P. Bahety, S. Liu and S. V. Seow, Y. Y. Yang and P. L. R. Ee, "Synthetic Modifications of the Immunomodulating Peptide Thymopentin to Confer Anti-Mycobacterial Activity," Biomaterials, (2014) DOI: 10.1016/j.biomaterials.2013.12.049

  80. D. J. Coady, Z. Y. Ong, P. S. Lee, S. Venkataraman, W. Chin, A. C. Engler, Y. Y. Yang and J. L. Hedrick, "Enhancement of Cationic Antimicrobial Materials via Cholesterol Incorporation," Advanced Healthcare Materials, (2013) DOI: 10.1002/adhm.201300554

  81. L. S. Wang. C. Du, W. S. Toh, A. C. A. Wan, S. J. Gao and M. Kurisawa, "Modulation of Chondrocyte Functions and Stiffness-Dependent Cartilage Repair Using an Injectable Enzymatically Crosslinked Hydrogel with Tunable Mechanical Properties," Biomaterials, 35 (2014) 2207-2217

  82. K. Fukushima, S. Liu, H. Wu, A. C. Engler, D. J. Coady, H. Maune, J. Pitera, A. Nelson, N. Wiradharma, S. Venkataraman, Y. Huang, W. Fan, J. Y. Ying, Y. Y. Yang and J. L. Hedrick, "Supramolecular High Aspect Ratio Assemblies with Strong Antifungal Activity," Nature Communications, (2013) DOI: 10.1038/ncomms3861

  83. J. S. Khara, Y. Wang, X. Y. Ke, S. Liu, S. M. Newton, P. R. Langford, Y. Y. Yang and P. L. R. Ee, "Anti-Mycobacterial Activities of Synthetic Cationic α-Helical Peptides and their Synergism with Rifampicin," Biomaterials, 35[6] (2014) 2032-2038

  84. J. Zeng and S. Wang, "Human Dendritic Cells Derived From Embryonic Stem Cells Stably Modified with CD1d Efficiently Stimulate Antitumor Invariant Natural Killer T Cell Response," Stem Cells Translational Medicine, 3[1] (2014) 69-80

  85. W. Chin, C. Yang, V. W. L. Ng, Y. Huang, J. Cheng, Y. W. Tong, D. J. Coady, W. Fan, J. L. Hedrick and Y. Y. Yang, "Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity," Macromolecules, 46[22] (2013) 8797-8807

  86. A. C. Engler, J. P. K. Tan, D.J. Coady, V. W. L. Ng, Y. Yang and J. L. Hedrick, "Antimicrobial Polycarbonates: Investigating the Impact of Balancing Charge and Hydrophobicity Using a Same Centered Polymer Approach," Biomacromolecules, 14 (2013) 4331-4339

  87. Z. Y. Ong, J. Cheng, Y. Huang, K. Xu, Z. Ji, W. Fan and Y. Y. Yang, "Effect of Stereochemistry, Chain Length and Sequence Pattern on Antimicrobial Properties of Short Synthetic β-Sheet Forming Peptide Amphiphiles," Biomaterials, 35[4] (2014) 1315-1325

  88. X. Ke, V. W. L. Ng, S. Gao, Y. W. Tong, J. L. Hedrick and Y. Y. Yang, "Co-Delivery of Thioridazine and Doxorubicin Using Polymeric Micelles for Targeting Both Cancer Cells and Cancer Stem Cells," Biomaterials, 35[3] (2014) 1096-1108

  89. A. L. Z. Lee, V. W. L. Ng, S. Gao, J. L Hedrick and Y. Y. Yang, "Injectable Hydrogels from Triblock Copolymers of Vitamin E-Functionalized Polycarbonate and Poly(ethylene glycol) for Subcutaneous Delivery of Antibodies for Cancer Therapy," Advanced Functional Materials, (2013) DOI: 10.1002/adfm.201301307

  90. S. Venkataraman, J. L. Hedrick and Y. Y. Yang, "Fluorene-Functionalized Aliphatic Polycarbonates: Design, Syntheses and Aqueous Self-Assembly of Amphiphilic Block Copolymers," Polymer Chemistry, (2013) DOI: 10.1039/C3PY01207G

  91. M. Reithofer, K. H. Chan, A. Lakshmanan, D. H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang, and C. A. E. Hauser, "Ligation of Anti-Cancer Drugs to Self-Assembling Ultrashort Peptides by Click Chemistry for Localized Therapy," Chemical Science, 5 (2013) 625-630

  92. Z. Y. Ong, C. Yang, S. J. Gao, X. Y. Ke, J. L. Hedrick, Y. Y. Yang, "Galactose-Functionalized Cationic Polycarbonate Diblock Copolymer for Targeted Gene Delivery to Hepatocytes," Macromolecular Rapid Communications, 34[21] (2013) 1714-1720

  93. A. L. Z. Lee, V. W. L. Ng, W. Wang, J. L. Hedrick and Y. Y. Yang, "Block Copolymer Mixtures as Antimicrobial Hydrogels for Biofilm Eradication," Biomaterials, 34[38] (2013) 10278-10286

  94. V. W. L. Ng, X. Ke, A. L. Z. Lee, J. L. Hedrick and Y. Y. Yang, "Synergistic Co-Delivery of Membrane-Disrupting Polymers with Commercial Antibiotics against Highly Opportunistic Bacteria," Advanced Materials, 25[46] (2013) 6730-6736

  95. H. Zhu, C.-H. Lau, S.-L. Goh, Q. Liang, C. Chen, S. Du, R.-Z. Phang, F. C. Tay, W.-K. Tan, Z. Li, J. C.-K. Tay, W. Fan and S. Wang, "Baculoviral Transduction Facilitates TALEN-Mediated Targeted Transgene Integration and Cre/LoxP Cassette Exchange in Human-Induced Pluripotent Stem Cells," Nucleic Acids Research, 41[19] (2013) e180

  96. K. H. Bae, L. S. Wang and M. Kurisawa, "Injectable Biodegradable Hydrogels: Progress and Challenges," Journal of Materials Chemistry B, 1[40] (2013) 5371-5388

  97. P. Y. Teo, C. Yang, J. L. Hedrick, A. C. Engler, D. J. Coady, S. Ghaem-Maghami, A. J. T. George and Y. Y. Yang, "Hydrophobic Modification of Low Molecular Weight Polyethylenimine for Improved Gene Transfection," Biomaterials, 34[32] (2013) 7971-7979

  98. M. Shahbazi, T. W. X. Kwang, Y. I. Purwanti, W. Fan and S. Wang, "Inhibitory Effects of Neural Stem Cells Derived from Human Embryonic Stem Cells on Differentiation and Function of Monocyte-Derived Dendritic Cells," Journal of the Neurological Sciences, 330[1] (2013) 85-93

  99. N. Han, Y. Y. Yang, S. Wang, S. Zheng and W. Fan, "Polymer-Based Cancer Nanotheranostics: Retrospectives of Multi-Functionalities and Pharmacokinetics," Current Drug Metabolism, 14[6] (2013) 661-674

  100. R. Mathieu, J. A. De Toro, D. Salazar, S. S. Lee, J. L. Cheong and P. Nordblad, "Phase Transition in a Super Superspin Glass," Europhysics Letters, 102 (2013) 67002

  101. D. Zhu, D. H. Lam, Y. I. Purwanti, S. L. Goh, C. Wu, J. Zeng, W. Fan and S. Wang, "Systemic Delivery of Fusogenic Membrane Glycoprotein-Expressing Neural Stem Cells to Selectively Kill Tumor Cells," Molecular Therapy, 21 (2013) 1621-1630

  102. S. Venkataraman, A. L. Lee, H. T. Maune, J. L. Hedrick, V. M. Prabhu, and Y. Y. Yang, "Formation of Disk- and Stacked-Disk-like Self-Assembled Morphologies from Cholesterol-Functionalized Amphiphilic Polycarbonate Diblock Copolymers," Macromolecules, (2013) DOI: 10.1021/ma400423b

  103. C. Q. Wang, L. Motoda, M. Satake, Y. Ito, I. Taniuchi, V. Tergaonkar and M. Osato, "Runx3 Deficiency Results in Myeloproliferative Disorder in Aged Mice," Blood, 122 (2013) 562-566

  104. A. C. Engler, J. M. W. Chan, K. Fukushima, D. J. Coady, Y. Y. Yang and J. L. Hedrick, "Polycarbonate-Based Brush Polymers with Detachable Disulfide-Linked Side Chains," ACS Macroletters, 2[4] (2013) 332-336

  105. D. J. Coady, H. W. Horn, G. O. Jones, H. Sardon, A. C. Engler, R. M. Waymouth, J. E. Rice, Y. Y. Yang and J. L. Hedrick, "Polymerizing Base Sensitive Cyclic Carbonates Using Acid Catalysis," ACS Macroletters, 2[4] (2013) 306-312

  106. Y. Zhao, S. L. Lo, Y. Zheng, D. H. Lam, C. Wu, M. Y. Han and S. Wang, "Quantum Dot Coating of Baculoviral Vectors Enables Visualization of Transduced Cells and Tissues," Biochemical and Biophysical Research Communications, 434 (2013) 110-116

  107. S. Venkataraman, N. Veronica, Z. X. Voo, J. L. Hedrick and Y. Y. Yang, "2-Amino-1,3-Propane Diols: A Versatile Platform for the Syn-Theses of Aliphatic Cyclic Carbonate Monomers," Polymer Chemistry, (2013) DOI: 10.1039/C3PY00318C

  108. H. Sardon, A. Engler, J. M. W. Chan, D. Coady, J. M. O'Brien, D. Mecerreyes, Y. Y. Yang and J. Hedrick, "Homogeneous Isocyanate- and Catalyst-Free Synthesis of Polyurethanes in Aqueous Media," Green Chemistry, (2013) DOI: 10.1039/C3GC40319J

  109. L. Liu, J. Yang, J. Xie, Z. Luo, J. Jiang, Y. Y. Yang and S. Liu, "The Potent Antimicrobial Properties of Cell Penetrating Peptide-Conjugated Silver Nanoparticles with Excellent Selectivity for Gram-Positive Bacteria over Erythrocytes," Nanoscale, (2013) DOI: 10.1039/c3nr34254a

  110. Z. Y. Ong, S. J. Gao and Y. Y. Yang, "Short Synthetic β-Sheet Forming Peptide Amphiphiles as Broad Spectrum Antimicrobials with Antibiofilm and Endotoxin Neutralizing Capabilities," Advanced Functional Materials, 23[29] (2013) 3682-3692

  111. W. Cheng, C. Yang, J. L. Hedrick, D. F. Williams, Y. Y. Yang and P. G. Ashton-Rickardt, "Delivery of a Granzyme B Inhibitor Gene Using Carbamate-Mannose Modified PEI Protects Against Cytotoxic Lymphocyte Killing," Biomaterials, 34[14] (2013) 3697-3705

  112. A. C. Engler, J. M. W. Chan, D. J. Coady, J. M. O'Brien, H. Sardon, A. Nelson, D. P. Sanders, Y. Y. Yang and J. L. Hedrick, "Accessing New Materials through Polymerization and Modification of a Polycarbonate with a Pendant Activated Ester," Macromolecules, 46[4] (2013) 1283-1290

  113. A. B. E. Attia, C. Yang, J. P.K. Tan, S. Gao, D. F. Williams, J. L. Hedrick and Y. Yan Yang, "The Effect of Kinetic Stability on Biodistribution and Anti-Tumor Efficacy of Drug-Loaded Biodegradable Polymeric Micelles," Biomaterials, 34[12] (2013) 3132-3140

  114. Y. Li, K. Fukushima, D. J. Coady, A. C. Engler, S. Liu, Y. Huang, J. S. Cho, Y. Guo, L. S. Miller, J. P. K. Tan, P. L. R. Ee, W. Fan, Y. Y. Yang, and J. L. Hedrick, "Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies," Angewandte Chemie International Edition, (2012) DOI: 10.1002/anie.201206053

  115. Y. Choudhury, F. C. Tay, D. H. Lam, E. Sandanaraj, C. Tang, B. T. Ang and S. Wang, "Attenuated Adenosine-to-Inosine Editing of MicroRNA-376a* Promotes Invasiveness of Glioblastoma Cells," Journal of Clinical Investigation, 122[11] (2012) 4059-4076

  116. J. Lin, S. Teo, D.H. Lam. K. Jeyaseelan and S. Wang, "MicroRNA-10b Pleiotropically Regulates Invasion, Angiogenicity and Apoptosis of Tumor Cells Resembling Mesenchymal Subtype of Glioblastoma Multiforme," Cell Death and Disease, 3 (2012) e398

  117. S. Q. Liu, C. Yang, Y. Huang, X. Ding, Y. Li, W. M. Fan, J. L. Hedrick and Y. Y. Yang, "Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition," Advanced Materials, (2012) DOI: 10.1002/adma.201202225

  118. K. Fukushima, J. P. K. Tan, P. A. Korevaar, Y. Y. Yang, J. Pitera, A. Nelson, H. Maune, D. J. Coady, J. E. Frommer, A. C. Engler, Y. Huang, K. Xu, Z. Ji, Y. Qiao, W. Fan, L. Li, N. Wiradharma, E. W. Meijer and J. L. Hedrick, "Broad-Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape," ACS Nano, (2012) DOI: 10.1021/nn3035217

  119. Y. Huang, N. Wiradharma, K. Xu, Z. Ji, S. Bi, L. Li, Y.-Y. Yang, W. Fan, "Cationic Amphiphilic Alpha-Helical Peptides for the Treatment of Carbapenem-Resistant Acinetobacter Baumannii Infection," Biomaterials, (2012) DOI: 10.1016/j.biomaterials.2012.08.026

  120. Y. Huang, N. Wiradharma, K. Xu, Z. Ji, S. Bi, L. Li, Y. Y. Yang and W. Fan, "Cationic Amphiphilic Alpha-Helical Peptides for the Treatment of Carbapenem-Resistant Acinetobacter Baumannii Infection," Biomaterials, 33[34] (2012) 8841-8847

  121. L. Liu, Y. Huang, S. N. Riduan, S. Gao, Y. Yang, W. Fan, Y. Zhang, "Main-Chain Imidazolium Oligomer Material as a Selective Biomimetic Antimicrobial Agent," Biomaterials, (2012) DOI: 10.1016/j.biomaterials.2012.08.006

  122. X. Ding, C. Yang, T. P. Lim, L. Y. Hsu, A. C. Engler, J. L. Hedrick and Y. Y. Yang, "Antibacterial and Antifouling Catheter Coatings Using Surface Grafted PEG-b-Cationic Polycarbonate Diblock Copolymers," Biomaterials, (2012) DOI: 10.1016/j.biomaterials.2012.06.001

  123. Y. Li , C. Yang,M. Khan, S. Q. Liu, J. L. Hedrick, Y. Y. Yang and P-L. R. Ee, "Nanostructured PEG-Based Hydrogels with Tunable Physical Properties for Gene Delivery to Human Mesenchymal Stem Cells," Biomaterials, (2012) DOI: 10.1016/j.biomaterials.2012.05.043

  124. M. Khan, Z. Y. Ong, N. Wiradharma, A. Bte Ebrahim Attia and Y. Y. Yang, "Advanced Materials for Co-Delivery of Drugs and Genes in Cancer Therapy," Advanced Healthcare Materials, (2012) DOI: 10.1002/adhm.201200109

  125. X. D. Guo, N. Wiradharma, S. Q. Liu, L. J. Zhang, M. Khan, Y. Qian and Y. Y. Yang, "Oligomerized Alpha-Helical KALA Peptides with Pendant Arms Bearing Cell-Adhesion, DNA-Binding and Endosome-Buffering Domains as Efficient Gene Transfection Vectors," Biomaterials, 33[26] (2012) 6284–6291

  126. J. Yang, G. Balasundaram, S.-L. Lo, E. C. S. Guang, J. M. Xue, J. Song, A. C. A. Wan, J. Y. Ying, and S. Wang, "Microfibers Fabricated by Non-Covalent Assembly of Peptide and DNA for Viral Vector Encapsulation and Cancer Therapy," Advanced Materials, 24[24] (2012) 3280-3284

  127. A. C. Englera, N. Wiradharma, Z. Y. Ong, D. J. Coadya, J. L. Hedrick and Y. Y. Yang, "Emerging Trends in Macromolecular Antimicrobials to Fight Multi-Drug-Resistant Infections," Nano Today, 7[3] (2012) 201–222

  128. S. L. Lo, S. Lua, J. Song, and S. Wang, "A β-Sheet Structure Interacting Peptide for Intracellular Protein Delivery into Human Pluripotent Stem Cells and their Derivatives," Biochemical and Biophysical Research Communications, 421[3] (2012) 616-620

  129. M. Khan, C. Y. Ang, N. Wiradharma, L.-K. Yong, S. Liu, L. Liu, S. Gao, and Y.-Y. Yang, "Diaminododecane-based Cationic Bolaamphiphile as a Non-Viral Gene Delivery Carrier," Biomaterials, 33[18] (2012) 4673-4680

  130. J. Zeng, M. Shahbazi, C. Wu and S. Wang, "Enhancing Immunostimulatory Function of Human Embryonic Stem Cell-Derived Dendritic Cells by CD1d Overexpression," The Journal of Immunology, (2012) DOI: 10.4049/jimmunol.1102343

  131. W. S. Toh, T. C. Lim, M. Kurisawa, and M. Spector, "Modulation of Mesenchymal Stem Cell Chondrogenesis in a Tunable Hyaluronic Acid Hydrogel Microenvironment," Biomaterials, 33[15] (2012) 3835-3845

  132. L.-S. Wang, C. Du, J. E. Chung, and M. Kurisawa, "Enzymatically Cross-Linked Gelatin-Phenol Hydrogels with a Broader Stiffness Range for Osteogenic Differentiation of Human Mesenchymal Stem Cells," Acta Biomaterialia, 8[5] (2012) 1826-1837

  133. J. Yang, D. H. Lam, S. S. Goh, E. X. Lee, Y. Zhao, F. C. Tay, C. Chen, S. Du, G. Balasundaram, M. Shahbazi, C. K. Tham, W. H. Ng, H. C. Toh, and S. Wang, "Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-derived Neural Stem Cells and their Gene Therapy Application in a Metastatic Breast Cancer Model," Stem Cells, 30[5] (2012) 1021-1029

  134. T. C. Lim, W. S. Toh, L.-S. Wang, M. Kurisawa, and M. Spector, "The Effect of Injectable Gelatin-Hydroxyphenylpropionic Acid Hydrogel Matrices on the Proliferation, Migration, Differentiation and Oxidative Stress Resistance of Adult Neural Stem Cells," Biomaterials, 33[12] (2012) 3446-3455

  135. S. L. Lo and S. Wang, "Evaluation of the Use of Amphipathic Peptide-Based Protein Carrier for In Vitro Cancer Research," Biochemical and Biophysical Research Communications, 419[2] (2012) 170-174

  136. K. Xu, F. Lee, S. J. Gao, J. E. Chung, H. Yano and M. Kurisawa, "Injectable Hyaluronic Acid-Tyramine Hydrogels Incorporating Interferon-α2a for Liver Cancer Therapy," Journal of Controlled Release, 166[3] (2013) 203-210

  137. C. Yang, A. B. Ebrahim Attia, J. P. K. Tan, X. Ke, S. Gao, J. L. Hedrick and Y. Y. Yang, "The Role of Non-Covalent Interactions in Anticancer Drug Loading and Kinetic Stability of Polymeric Micelles," Biomaterials, 33[10] (2012) 2971-2979

  138. N. Wiradharma, S. Q. Liu and Y. Y. Yang, "Branched and 4-Arm Starlike α-Helical Peptide Structures with Enhanced Antimicrobial Potency and Selectivity," Small, 8[3] (2011) 362-366

  139. A. L. Z. Lee, S. Venkataraman, S. B. M. Sirata, S. Gao, J. L. Hedrick and Y. Y. Yang, "The Use of Cholesterol-Containing Biodegradable Block Copolymers to Exploit Hydrophobic Interactions for the Delivery of Anticancer Drugs," Biomaterials, 33[6] (2011) 1921-1928

  140. C. Wu and S. Wang, "A pH-Sensitive Heparin-Binding Sequence from Baculovirus gp64 Protein Is Important for Binding to Mammalian Cells but Not to fSf9 Insect Cells," Journal of Virology, 86 (2011) 484

  141. Y. Qiao, C. Yang, D. J. Coady, Z. Y. Ong, J. L. Hedrick and Y. Y. Yang, "Highly Dynamic Biodegradable Micelles Capable of Lysing Gram-Positive and Gram-Negative Bacterial Membrane," Biomaterials, 33[4] (2011) 1146-1153

  142. K. Xu, H. Wang, L. Liu, W. Xu, J. Sheng, W. Fan, Y. Y. Yang and L. Li, "Efficacy of CG(3)R(6)TAT Nanoparticles Self-Assembled from a Novel Antimicrobial Peptide for the Treatment of Candida Albicans Meningitis," Chemotherapy, 57[5] (2011) 417-425

  143. L. S. Wang, J. E. Chung and M. Kurisawa, "Controlling Fibroblast Proliferation with Dimensionality-Specific Response by Stiffness of Injectable Gelatin Hydrogels," Journal of Biomaterials Science, Polymer Edition, 23[14] (2011) 1793-1806

  144. C. Yang, Z. Y. Ong, Y. Y. Yang, P. L. Ee and J .L. Hedrick, "Novel Biodegradable Block Copolymers of Poly(ethylene glycol) (PEG) and Cationic Polycarbonate: Effects of PEG Configuration on Gene Delivery," Macromolecular Rapid Communications, 32 (2011) 1826-1833

  145. D. J. Coady, A. C. Englerand Y. Y. Yang and J. L. Hedrick, "Facile Routes to Star Polymers via an Organocatalytic Approach," Polymer Chemistry, 2 (2011) 2619-2626

  146. N. Wiradharma, M. Khan, L-K. Yong, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang, "The Effect of Thiol Functional Group Incorporation into Cationic Helical Peptides on Antimicrobial Activities and Spectra," Biomaterials, 32[34] (2011) 9100-9108

  147. E.X. Lee, D. H Lam, C. Wu, J. Yang, C. K. Tham, W. H. Ng and S. Wang, "Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells," Molecular Pharmaceutics, 8[5] (2011) 1515-1524

  148. S. Venkataraman, J. L. Hedrick, Z. Y. Ong, C. Yang, P. L. R. Ee, P. T. Hammond and Y. Y. Yang, "The Effects of Polymeric Nanostructure Shape on Drug Delivery," Advanced Drug Delivery Reviews, 63 (2011) 1228-1246

  149. S.L. Lo, Y. Choudhury and S. Wang, "Peptide-Based Nanomaterials for siRNA Delivery: Design, Evaluation and Challenges," Nanobiomaterials Handbook, (2011) DOI: 10.1201/b10970-10

  150. C. J. A. Ramachandra, M. Shahbazi, T. W. X. Kwang, Y. Choudhury, X. Y. Bak, J. Yang and S. Wang, "Efficient Recombinase-Mediated Cassette Exchange at the AAVS1 Locus in Human Embryonic Stem Cells Using Baculoviral Vectors," Nucleic Acids Research, 39 (2011) e107

  151. Y. Zhao, D. H. Lam, J. Yang, C. K. Tham, W. H. Ng and S. Wang, "Targeted Suicide Gene Therapy for Glioma Using Human Embryonic Stem Cell-Derived Neural Stem Cells Genetically Modified by Baculorviral Vectors," Gene Therapy, 19[2] (2011) 189-200

  152. S. H. Kim, J. P.K. Tan, K. Fukushima, F. Nederberg, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick, "Thermoresponsive Nanostructured Polycarbonate Block Copolymers as Biodegradable Therapeutic Delivery Carriers," Biomaterials, 32[23] (2011) 5505-5514

  153. M. Sugai, K. Aoki, M. Osato, Y. Nambu, K. Ito, M. M. Taketo and A. Shimizu, "Runx3 is Required for Full Activation of Regulatory T Cells to Prevent Colitis-Associated Tumor Formation," The Journal of Immunology, 186[11] (2011) 6515-6520

  154. T. Yokomizo, C. E. L. Ng, M. Osato and E. Dzierdzak, "Three-Dimensional Imaging of Whole Midgestation Murine Embryos Shows an Intravascular Localization for All Hematopoeitic Clusters," Blood, 117 (2011) 6132-6134

  155. F. Nederberg, Y. Zhang, J. P. K. Tan, K. Xu, H. Wang, C. Yang, S. Gao, X. D. Guo, K. Fukushima, L. Li, J. L. Hedrick and Y. Y. Yang, "Biodegradable Nanostructures with Selective Lysis of Microbial Membranes," Nature Chemistry, 3 (2011) 409-414

  156. X. Y. Bak*, H. L. Dang*, J. Yang, K. Ye, E. X. W. Lee, S. K. Lim and S. Wang, "Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma.," Human Gene Therapy, 22[11] (2011) 1365-1377

  157. A. L. Z. Lee, S. H. K. Dhillon, Y. Wang, S. Pervaiz, W. Fan and Y. Y. Yang, "Synergistic Anti-Cancer Effects Via Co-Delivery of TNF-Related Apoptosis-Inducing Ligand (TRAIL/Apo2L) and Doxorubicin Using Micellar Nanoparticles," Molecular BioSystems, 7[5] (2011) 1512-1522

  158. Z. Y. Ong, P. L. R. Ee, Y. Y. Yang, K. Fukushima, D. J. Coady and J. L. Hedrick, "Rational Design of Biodegradable Cationic Polycarbonates for Gene Delivery," Journal of Controlled Release, 152[1] (2011) 120-126

  159. Y. F. Tan, P. Chandrasekharan, D. Maity, C. X. Yong, K. H. Chuang, Y. Zhao, S. Wang, J. Ding and S.-S. Feng, "Multimodal Tumor Imaging by Iron Oxides and Quantum Dots Formulated in Poly(lactic Acid)-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles," Biomaterials, 32[11] (2011) 2969-2978

  160. J. C. M. Teo, R. R. G. Ng, C. P. Ng and A. W. H. Lin, "Surface Characteristics of Acrylic Modified Polysulfone Membranes Improves Renal Proximal Tubule Cell Adhesion and Spreading," Acta Biomaterialia, 7[5] (2011) 2060-2069

  161. S. Venkataraman, W. L. Ong, Z. Y. Ong, S. C. J. Loo, P. L. R. Ee and Y. Y. Yang, "The Role of PEG Architecture and Molecular Weight in the Gene Transfection Performance of PEGylated Poly(dimethylaminoethyl methacrylate)-Based Cationic Polymers," Biomaterials, 32[9] (2010) 2369-2378

  162. N. Wiradharma, U. Khoe, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang, "Synthetic Cationic Amphiphilic α-Helical Peptides as Antimicrobial Agents," Biomaterials, 32[8] (2010) 2204-2212

  163. A. L. Z. Lee, Y. Wang, S. Pervaiz and Y. Y. Yang, "Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles," Macromolecular Bioscience, 11[2] (2010) 296-307

  164. H. Guo, Y. Choudhury, J. Yang, C. Chen, F. C. Tay, T. M. Lim and S. Wang, "Antiglioma Effects of Combined Use of a Baculoviral Vector Expressing Wild-Type p53 and Sodium Butyrate," Journal of Gene Medicine, 13[1] (2010) 26-36

  165. C. Yang, J. P. K. Tan, W. Cheng, A. Bte Ebrahim Attia, C. Y. T. Tan, A. Nelson, J. L. Hedrick and Y. Y. Yang, "Supramolecular Nanostructures Designed for High Cargo Loading Capacity and Kinetic Stability," Nano Today, 5[6] (2010) 515-523

  166. A. Bte Ebrahim Attia, Z. Y. Ong, J. L. Hedrick, P. P. Lee, R. P. L. Ee, P. T. Hammond and Y. Y. Yang, "Mixed Micelles Self-Assembled from Block Copolymers for Drug Delivery," Current Opinion in Colloid & Interface Science, 16[3] (2010) 182-194

  167. E. L. C. Ng, Y. Yokomizo, N. Yamashita, B. Cirovic, H. Jin, Z. Wen, Y. Ito and M. Osato, "A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells," Stem Cells, 28[10] (2010) 1869-1881

  168. J. Wang, S.-S. Feng, S. Wang and Z.-Y. Chen, "Evaluation of Cationic Nanoparticles of Biodegradable Copolymers as siRNA Delivery System for Hepatitis B Treatment," International Journal of Pharmaceutics, 400[1-2] (2010) 194-200

  169. S. L. Lo and S. Wang, "Peptide-Based Nanocarriers for Intracellular Delivery of Biologically Active Proteins," Organelle-Specific Pharmaceutical Nanotechnology, (2010) DOI: 10.1002/9780470875780.ch18

  170. Y. T. Wong, J. Gruber, A. M. Jenner, F. E. H. Tay and R. S. Ruan, "Chronic Resveratrol Intake Reverses Pro-Inflammatory Cytokine Profile and Oxidative DNA Damage in Ageing Hybrid Mice," Age, 33[3] (2010) 229-246

  171. L. S. Wang, J. Boulaire, P. P. Y. Chan, J. E. Chung and M. Kurisawa, "The Role of Stiffness of Gelatin-Hydroxyphenylpropionic Acid Hydrogels Formed by Enzyme-Mediated Crosslinking on the Differentiation of Human Mesenchymal Stem Cell," Biomaterials, 31[33] (2010) 8608-8616

  172. S. H. Kim, J. P. K. Tan, F. Nederberg, K. Fukushima, J. Colson, C. Yang, A. Nelson, Y. Y. Yang and J. L. Hedrick, "Hydrogen Bonding-Enhanced Micelle Assemblies for Drug Delivery," Biomaterials, 31[31] (2010) 8063-8071

  173. S. Q. Liu, Q. Tian, J. L. Hedrick, J. H. P. Hui, P. L. R. Ee and Y. Y. Yang, "Biomimetic Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stem Cells to Neocartilage," Biomaterials, 31[28] (2010) 7298-7307

  174. L. Li, H. Wang, Z. Y. Ong, K. Xu, P. L. R. Ee, S. Zheng, J. L. Hedrick and Y. Y. Yang, "Polymer- and Lipid-Based Nanoparticle Therapeutics for the Treatment of Liver Diseases," Nano Today, 5[4] (2010) 296-312

  175. M. Khan, N. Wiradharma, G Beniah, N. M. Rafiq, S. Q. Liu, J. Au and Y. Y. Yang, "Branched Disulfide-Based Polyamidoamines Capable of Mediating High Gene Transfection," Current Pharmaceutical Design, 16[21] (2010) 2341-2349

  176. J. P. K. Tan, S. H. Kim, F. Nederberg, K. Fukushima, D. J. Coady, A. Nelson, Y. Y. Yang and J. L. Hedrick, "Delivery of Anticancer Drugs Using Polymeric Micelles Stabilized by Hydrogen-Bonding Urea Groups," Macromolecular Rapid Communications, 31[13] (2010) 1187-1192

  177. N. Wiradharma, Y. W. Tong and Y. Y. Yang, "Design and Evaluation of Peptide Amphiphiles with Different Hydrophobic Blocks for Simultaneous Delivery of Drugs and Genes," Macromolecular Rapid Communications, 31[13] (2010) 1212-1217

  178. X. Y. Bak, J. Yang and S. Wang, "Baculovirus-Transduced Bone Marrow Mesenchymal Stem Cells for Systemic Cancer Therapy," Cancer Gene Therapy, 17[10] (2010) 721-729

  179. S. Wang and G. Balasundaram, "Potential Cancer Gene Therapy by Baculoviral Transduction," Current Gene Therapy, 10[3] (2010) 214-225

  180. S. Q. Liu, Q. Tian, L. Wang, J. L. Hedrick, J. H. P. Hui, Y. Y. Yang and P. L. R. Ee, "Injectable Biodegradable Poly(ethylene glycol)/RGD Peptide Hybrid Hydrogels for In Vitro Chondrogenesis of Human Mesenchymal Stem Cells," Macromolecular Rapid Communications, 31[13] (2010) 1148-1154

  181. W. Y. Seow, Y. Y. Yang and A. J. T. George, "Novel Triblock Oligopeptides as Efficient Nonviral Vectors: Characterization and Further Insights," Macromolecular Rapid Communications, 31[13] (2010) 1170-1174

  182. S. L. Lo and S. Wang, "Intracellular Protein Delivery Systems Formed by Noncovalent Bonding Interactions between Amphipathic Peptide Carriers and Protein Cargos," Macromolecular Rapid Communications, 31[13] (2010) 1134-1141

  183. Y. Zhao and S. Wang, "Human NT2 Neural Precursor Derived Tumor Infiltrating Cells as Delivery Vehicles for Treatment of Glioblastoma," Human Gene Therapy, 21[6] (2010) 683-694

  184. M. Kurisawa, F. Lee, L. S. Wang and J. E. Chung, "Injectable Enzymatically Crosslinked Hydrogel System with Independent Tuning of Mechanical Strength and Gelation Rate for Drug Delivery and Tissue Engineering," Journal of Materials Chemistry, 20[26] (2010) 5371-5375

  185. Y. C. Wang, Y. Li, T. M. Sun, M. H. Xiong, J. Wu, Y. Y. Yang and J. Wang, "Core-Shell-Corona Micelle Stabilized by Reversible Cross-Linkage for Intracellular Drug Delivery," Macromolecular Rapid Communications, 31[13] (2010) 1201-1206

  186. M. Khan, G. Beniah, N. Wiradharma, X. D. Guo and Y. Y. Yang, "Brush-Like Amphoteric Poly[isobutylene-alt-(maleic acid)-graft-oligoethyleneamine)]/DNA Complexes for Efficient Gene Transfection," Macromolecular Rapid Communciations, 31[13] (2010) 1142–1147

  187. C. Q. Wang, B. Jacob, G. S. S. Nah and M. Osato, "Runx, Niche and Stem Cell Quiescence," Blood Cells, Molecules and Diseases, 44[4] (2010) 275-286

  188. N. T. Zaman, Y. Y. Yang and J. Y. Ying, "Stimuli-Responsive Polymers for the Targeted Delivery of Paclitaxel to Hepatocytes," Nano Today, 5[1] (2010) 9-14

  189. F. Suriano, R. Pratt, J. P. K. Tan, N. Wiradharma, A. Nelson, Y. Y. Yang, P. Dubois and J. L. Hedrick, "Synthesis of a Family of Amphiphilic Glycopolymers via Controlled Ring-Opening Polymerization of Functionalized Cyclic Carbonates and Their Application in Drug Delivery," Biomaterials, 31[9] (2010) 2637-2645

  190. H. Wang, K. Xu, L. Liu, J. P. K. Tan , Y. Chen, Y. Li, W. Fan, Z. Wei, J. Sheng, Y. Y. Yang and L. Li, "The Efficacy of Self-Assembled Cationic Antimicrobial Peptide Nanoparticles Against Cryptococcus Neoformans for the Treatment of Meningitis," Biomaterials, 31[10] (2009) 2874-2881

  191. S. Venkataraman, Y. Zhang, L. Liu and Y. Y. Yang, "Design, Syntheses and Evaluation of Hemocompatible Pegylated-Antimicrobial Polymers with Well-Controlled Molecular Structures," Biomaterials, 31[7] (2009) 1751-1756

  192. S. Q. Liu, R. Tay, M. Khan, P. L. R. Ee, J. L. Hedrick and Y. Y. Yang, "Synthetic Hydrogels for Controlled Stem Cell Differentiation," Soft Matter, 6[1] (2009) 67-81

  193. H. P. Song, J. Y. Yang, S. L. Luo, Y. Wang, W. M. Fan, X. S. Tang, J. M. Xue and S. Wang, "Gene Transfer Using Self-Assembled Ternary Complexes of Cationic Magnetic Nanoparticle, Plasmid DNA and Cell-Penetrating Tat Peptide," Biomaterials, 31[4] (2010) 769-778

  194. C. X. Wu, J. K. Lin, M. Hong, D. Leung, Y. Choudhury, P. Balani, J. M. Zeng, J. Boulaire and S. Wang, "Combinatorial Control of Suicide Gene Expression by Tissue-Specific Promoter and microRNA Regulation for Cancer Therapy," Molecular Therapy, 17[12] (2009) 2058-2066

  195. X. D. Guo, J. P. K. Tan, S. H. Kim, L. J. Zhang, Y. Zhang, J. L. Hedrick, Y. Y. Yang and Y. Qian, "Computational Studies on Self-Assembled Paclitaxel Structures: Templates for Hierarchical Block Copolymer Assemblies and Sustained Drug Release," Biomaterials, 30[33] (2009) 6556-6563

  196. W. Y. Seow, Y. Y. Yang and A. George, "Oligopeptide-Mediated Gene Transfer into Mouse Corneal Endothelial Cells: Expression, Design Optimization, Uptake Mechanism and Nuclear Localization," Nucleic Acids Research, 37[18] (2009) 6276-6289

  197. J. Zeng, J. Du, J. Boulaire, Y. Zhao and S. Wang, "The Combined Use of Viral Transcriptional and Post-Transcriptional Regulatory Elements to Improve Baculovirus-Mediated Transient Gene Expression in Human Embryonic Stem Cells," Journal of Bioscience and Bioengineering, 109[1] (2009) 1-8

  198. Y. Yang, S. L. Lo, J. Y. Yang, J. Yang, S. S. L. Goh, C. X. Wu, S. S. Feng and S. Wang, "Polyethylenimine Coating to Produce Serum-Resistant Baculoviral Vectors for In Vivo Gene Delivery," Biomaterials, 30[29] (2009) 5767-5774

  199. Nikken Wiradharma, Ying Zhang, Shrinivas Venkataraman, James L. Hedrick, and Yi Yan Yang, "Self-Assembled Polymer Nanostructures for Delivery of Anticancer Therapeutics," Nano Today, 4[4] (2009) 302-317

  200. L. Liu, K. Xu, H. Wang, J. P. K. Tan, W. Fan, S. S. Venkatraman, L. Li and Y. Yang, "Self-Assembled Cationic Peptide Nanoparticles as an Efficient Antimicrobial Agent," Nature Nanotechnology, 4 (2009) 457-463

  201. J. M. Zeng, J. Du, J. K. Lin, X. Y. Bak, C. X. Wu and S. Wang, "High-Efficiency Transient Transduction of Human Embryonic Stem Cell-Derived Neurons with Baculoviral Vectors," Molecular Therapy, 17[9] (2009) 1585-1593

  202. J. Chen and R. S. Ruan, "Identifying Stable Reference Genes for Evaluation of Antioxidative Enzyme Gene Expression in Auditory Cortex and Cochlea of Young and Old Fischer 344 Rats," Acta Octo-Laryngologica, 129[6] (2009) 644-650

  203. M. C. Tan, J. Y. Ying, and G. M. Chow, "Interfacial Properties and In Vitro Cytotoxic Effects of Surface?Modified Near Infrared Absorbing Au?Au2S Nanoparticles," Journal of Materials Science: Materials in Medicine, 20[10] (2009) 2091-2103

  204. W. Y. Seow and Y. Y. Yang, "Functional Polycarbonates and Their Self-Assemblies as Promising Non-Viral Vectors," Journal of Controlled Release, 139[1] (2009) 40-47

  205. S. H. Kim, F. Nederberg, R. Jakobs, J. P. K. Tan, K. Fukushima, A. Nelson, E. W. Meijer, Y. Y. Yang and J. L. Hedrick, "A Supramolecularly Assisted Transformation of Block Copolymer Micelles into Nanotubes," Angewandte Chemie International Edition, 48[25] (2009) 4508-4512

  206. Y. Yan, J. Du, T. S. Chen, M. S. Yi, M. Y. Li, S. Wang, C. M. Li and Y. H. Hong, "Establishment of Medakafish as a Model for Stem Cell-based Gene Therapy: Efficient Gene Delivery and Potential Chromosomal Integration by Baculoviral Vectors," Experimental Cell Research, 315[13] (2009) 2322-2331

  207. J. Boulaire, P. Balani and S. Wang, "Transcriptional Targeting to Brain Cells: Engineering Cell Type-Specific Promoter Containing Cassettes for Enhanced Transgene Expression," Advanced Drug Delivery Reviews, 61[7-8] (2009) 589-602

  208. F. Nederberg, E. Appel, J. P. K. Tan, S. H. Kim, K. Fukushima, J. Sly, R. D. Miller, R. M. Waymouth, Y. Y. Yang and J. L. Hedrick, "A Simple Approach to Stabilized Micelles Employing Mikto-arm Terpolymers and Stereocomplexes with Application in Paclitaxel Delivery," Biomacromolecules, 10[6] (2009) 1460-1468

  209. J. Boulaire, Y. Zhao and S. Wang, "Gene Expression Profiling to Define Host Response to Baculoviral Transduction in the Brain," Journal of Neurochemistry, 109[5] (2009) 1203-1214

  210. X. D. Guo, J. P. K. Tan, L. J. Zhang, M. Khan, S. Q. Liu, Y. Y. Yang and Y. Qian, "Phase Behavior Study of Paclitaxel Loaded Amphiphilic Copolymer in Two Solvents by Dissipative Particle Dynamics Simulations," Chemical Physics Letters, 473[4-6] (2009) 336-342

  211. N. Wiradharma, Y. W. Tong and Y. Y. Yang, "Self-Assembled Oligopeptide Nanostructures for Co-Delivery of Drug and Gene in Achieving Synergistic Therapeutic Effect," Biomaterials, 30[17] (2009) 3100-3109

  212. M. Hu, M. Kurisawa, R. Deng, C. M. Teo, A. Schumacher, Y. X. Thong, L. Wang, K. M. Schumacher and J. Y. Ying, "Cell Immobilization in Gelatin-Hydroxyphenylpropionic Acid Hydrogel Fibers," Biomaterials, 30[21] (2009) 3523-3531

  213. J. P. K. Tan, S. H. Kim, F. Nederberg, E. A. Appel, R. M. Waymouth, Y. Zhang, J. L. Hedrick and Y. Y. Yang, "Hierarchical Supermolecular Structures for Sustained Drug Release," Small, 5[13] (2009) 1504-1507

  214. P. Balani, J. Boulaire, Y. Zhao, J. Zeng, J. K. Lin and S. Wang, "High Mobility Group Box2 Promoter-Controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment," Molecular Therapy, 17[6] (2009) 1003-1011

  215. S. Q. Liu, P. L. R. Ee, C. Y. Ke, J. L. Hedrick and Y. Y. Yang, "Biodegradable Poly(ethylene glycol)-Peptide Hydrogels with Well-Defined Structure and Properties for Cell Delivery," Biomaterials, 30[8] (2009) 1453-1461

  216. C. Beh, W. Y. Seow, Y. Wang, Y. Zheng and Y. Y. Yang, "Delivery of Bcl-2-Targeted siRNA Using Cationic Polymer Micelles: Downregulation ofmRNA Expression Level and Sensitization of Cancer Cells to Anticancer Drug," Biomacromolecules, 10[1] (2009) 41-48

  217. S. H. Kim, F. Nederberg, J. Tan, K. Fukushima, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick, "Mixed Micelle Formation Through Stereocomplexation Between Enantiomeric Poly(lactide) Block Copolymers," Macromolecules, 42[1] (2009) 25-29

  218. F. Lee, J. E. Chung and M. Kurisawa, "An Injectable Hyaluronic Acid-Tyramine System for Protein Delivery," Journal of Controlled Release, 134[3] (2008) 186-193

  219. A. Lee, Y. Wang, H. Y. Cheng, S. Pervaiz and Y. Y. Yang, "Co-Delivery of Paclitaxel and Herceptin Using Cationic Micellar Nanoparticles: Achieving Enhanced Cytotoxicity and Targeting," Biomaterials, 30[5] (2009) 919-927

  220. W. Y. Seow and Y. Y. Yang, "A Class of Triblock Cationic Oligopeptides as Efficient Gene Delivery Vectors," Advanced Materials, 21[1] (2009) 86-90

  221. K. Fukushima, R. C. Pratt, F. Nederberg, J. Tan, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick, "Organocatalytic Approach to Amphiphilic Comb-Block Copolymers Capable of Stereocomplexation and Self-Assembly," Biomacromolecules, 9[11] (2008) 3051-3056

  222. F. Tandiono, X. D. Guo, N. Wiradharma, D. Khor, C. G. Tan, M. Khan, Y. Qian and Y. Y. Yang, "Cationic Micelles Self-Assembled from Cholesterol-Conjugated Oligopeptides as an Efficient Gene Delivery Vector," Biomaterials, 29[36] (2008) 4838-4846

  223. P. Pitukmanorom, T.-H. Yong and J. Y. Ying, "Tunable Release of Proteins with Polymer-Inorganic Nanocomposite Microspheres," Advanced Materials, 20[18] (2008) 3504-3509

  224. J. Jurvansuu, Y. Zhao, S. Y. Leung, J. Boulaire, Y. H. Yu, S. Ahmed and S. Wang, "TMEM18 Enhances the Tropism of Neural Stem Cells for Glioma Cells," Cancer Research, 68[12] (2008) 4614-4622

  225. C. X. Wu, S. L. Lo, J. Boulaire, M. L. W. Hong, H. M. Beh, S. Y. Leung and S. Wang, "A Peptide-based Carrier for Intracellular Delivery of Proteins into Malignant Glial Cells In Vitro," Journal of Controlled Release, 130[2] (2008) 140-145

  226. L. H. Liu, S. S. Venkatraman, Y. Y. Yang, K. Guo, J. Lu, B. P. He, S. Moochhala and L. J. Kan, "Polymeric Micelles Anchored with TAT for Delivery of Antibiotics across the Blood-Brain Barrier," Biopolymers, 90[5] (2008) 617-623

  227. N. Wiradharma, M. Khan, Y. W. Tong, S. Wang and Y. Y. Yang, "Self-Assembled Cationic Peptide Nanoparticles Capable of Inducing Efficient Gene Expression in vitro," Advanced Functional Materials, 18[6] (2008) 943-951

  228. B. H. Liu, S. Wang, M. Brenner, J. F. R. Paton and S. Kasparov, "Enhancement of Cell-Specific Transgene Expression from a Tet-Off Regulatory System Using a Transcriptional Amplification Strategy in the Rat Brain," Journal of Gene Medicine, 10[5] (2008) 583-592

  229. S. L. Lo and S. Wang, "An Endosomolytic TAT Peptide Produced by Incorporation of Histidine and Cysteine Residues as a New Nonviral Vector for Efficient DNA Transfection," Biomaterials, 29[15] (2008) 2408-2414

  230. F. Lee, J. E. Chung and M. Kurisawa, "An Injectable Enzymatically Crosslinked Hyaluronic Acid-Tyramine Hydrogel System with Independent Tuning of Mechanical Strength and Gelation Rate," Soft Matter, 4[4] (2008) 880-887

  231. A. Lee, Y. Wang, W. H. Ye, H. S. Yoon, S. Y. Chan and Y. Y. Yang, "Efficient Intracellular Delivery of Functional Proteins Using Cationic Polymer Core/Shell Nanoparticles," Biomaterials, 29[9] (2008) 1224-1232

  232. M. C. Tan, J. Y. Ying and G. M. Chow, "Composition, Particle Size and NIR Irradiation Effects on Optical Properties of Au-Au2S Nanoparticles," Journal of Materials Research, 23[1] (2008) 281-293

  233. L. H. Liu, K. Guo, J. Lu, S. S. Venkatraman, D. Luo, K. C. Ng, E. A. Ling, S. Moochhala and Y. Y. Yang, "Biologically Active Core/Shell Nanoparticles Self-Assembled from Cholesterol-Terminated PEG-TAT for Drug Delivery across the Blood-Brain Barrier," Biomaterials, 29[10] (2007) 1509-1517

  234. Q. Y. Meng, C. N. Velalar and R. S. Ruan, "Effects of Epigallocatechin-3-Gallate on Mitochondrial Integrity and Antioxidative Enzyme Activity in Aging Process of Human Fibroblast," Free Radical Biology and Medicine, 44[6] (2007) 1032-1041

  235. Z. Yue, S. B. M. Usuludn and H. Yu, "Bio-inspired Multifunctional Nanoassemblies for Intracellular Drug Delivery," Proceedings of the International Conference on Cellular and Molecular Bioengineering, (2007) DOI: -

  236. S. Moudgil and J. Y. Ying, "Calcium-Doped Organosilicate Nanoparticles as Gene Delivery Vehicles for Bone Cells," Advanced Materials, 19[20] (2007) 3130-3135

  237. B. Gopalan, M. Shanker, A. Scott, C. D. Branch, S. Chada and R. Ramesh, "MDA-7/IL-24, a Novel Tumor Suppressor/Cytokine is Ubiquitinated and Regulated by the Ubiquitin-Proteasome System, and Inhibition of MDA-7/IL-24 Degradation Enhances the Antitumor Activity," Cancer Gene Therapy, 15[1] (2007) 1-8

  238. M. C. Tan, J. Y. Ying and G. M. Chow, "Structure and Microstructure of Near Infrared-Absorbing Au-Au2S Nanoparticles," Journal of Materials Research, 22[9] (2007) 2531-2538

  239. Y. Wang, C. Y. Ke, C. W. J. Beh, S. Q. Liu, S. H. Goh and Y. Y. Yang, "The Self Assembly of Biodegradable Cationic Polymer Micelles as Vectors for Gene Transfection," Biomaterials, 28[35] (2007) 5358-5368

  240. C. X. Wu, K. Y. Soh and S. Wang, "Ion-Exchange Membrane Chromatography Method for Rapid and Efficient Purification of Recombinant Baculovirus and Baculovirus gp64 Protein," Human Gene Therapy, 18[7] (2007) 665-672

  241. G. Tresset, W. C. D. Cheong, Y. L. S. Tan, J. Boulaire and Y. M. Lam, "Phospholipid-based Artificial Viruses Assembled by Multivalent Cations," Biophysical Journal, 93[2] (2007) 637-644

  242. J. M. Zeng, J. Du, Y. Zhao, N. Palanisamy and S. Wang, "Baculoviral Vector-mediated Transient and Stable Transgene Expression in Human Embryonic Stem Cells," Stem Cells, 25[4] (2007) 1055-1061

  243. Y. Wang, L. S. Wang, S. H. Goh and Y. Y. Yang, "Synthesis and Characterization of Cationic Micelles Self-Assembled from A Biodegradable Copolymer for Gene Delivery," Biomacromolecules, 8[3] (2007) 1028-1037

  244. K. S. Soppimath, L. H. Liu, W. Y. Seow, S. Q. Liu, R. Powell, P. Chan and Y. Y. Yang, "Multi-Functional Polymer Core-Shell Nanoparticles Self-Assembled from pH-Induced Thermally Responsive Polymer for Targeted Anticancer Drug Delivery," Advanced Functional Materials, 17[3] (2007) 355-362

  245. Q. Y. Meng, Y. Wong, J. Chen and R. Ruan, "Age-related Changes in Mitochondrial Function and Antioxidative Enzyme Activity in Fischer 344 Rats," Mechanisms of Ageing and Developments, 128[3] (2007) 286-292

  246. W. Y. Seow, J. M. Xue and Y. Y. Yang, "Targeted and Intracellular Delivery of Paclitaxel Using Multi-functional Polymeric Micelles," Biomaterials, 28[9] (2006) 1730-1740

  247. J. Zeng, X. Wang and S. Wang, "Self-Assembled Ternary Complexes of Plasmid DNA, Low Molecular Weight Polyethylenimine and Targeting Peptide for Nonviral Gene Delivery into Neurons," Biomaterials, 28[7] (2006) 1443-1451

  248. S. Q. Liu, N. Wiradharmaa, S. J. Gao, Y. W. Tong and Y. Y. Yang, "Bio-functional Micelles Self-Assembled from a Folate-Conjugated Block Copolymer for Targeted Intracellular Delivery of Anticancer Drugs," Biomaterials, 28[7] (2006) 1423-1433

  249. P. Chan, M. Kurisawa, J. E. Chung and Y. Y. Yang, "Synthesis and Characterization of Chitosan-g-Poly(ethylene glycol)-Folate as a Non Viral Carrier for Tumor-Targeted Gene Delivery," Biomaterials, 28[3] (2006) 540-549

  250. Y. Wang, S. J. Gao, H. Wen, H. S. Yoon and Y. Y. Yang, "Co-delivery of Drugs and DNA from Cationic Core-Shell Nanoparticles Self-Assembled from a Biodegradable Copolymer," Nature Materials, 5[10] (2006) 791-796

  251. T. B. Bini, S. J.Gao, S. Wang and S. Ramakrishna, "Poly(l-lactide-co-glycolide) Biodegradable Microfibers and Electrospun Nanofibers for Nerve Tissue Engineering: An In Vitro Study," Journal of Materials Science, 41[19] (2006) 6453-6459

  252. Z. Shang, D. N. Ting, Y. T. Wong, Y. C. Tan, B. Ying and Y. Mo, "A Study of DFT and Surface Enhanced Raman Scattering in Silver Colloids for Thymine," Journal of Molecular Structure, 826[1] (2006) 64-67

  253. B. H. Liu, Y. Yang, J. F. R. Paton, F. Li, J. Boulaire, S. Kasparov and S. Wang, "GAL4-NF-κB Fusion Protein Augments Transgene Expression from Neuronal Promoters in the Rat Brain," Molecular Therapy, 14[6] (2006) 872-882

  254. F. Alexis, S. L. Lo and S. Wang, "Covalent Attachment of Low Molecular Weight Polyethylenimine Improves Tat Peptide-Mediated Gene Delivery," Advanced Materials, 18[16] (2006) 2174-2178

  255. G. P. Tang, H. Y. Guo, F. Alexis, X. Wang, S. Zeng, T. M. Lim, J. Ding, Y. Y. Yang and S. Wang, "Low Molecular Weight Polyethylenimines Linked by β-Cyclodextrin for Gene Transfer into the Nervous System," Journal of Gene Medicine, 8[6] (2006) 736-744

  256. C. Y. Wang, F. Li, Y. Yang, H. Y. Guo, C. X. Wu and S. Wang, "Recombinant Baculovirus Containing the Diphtheria Toxin A Gene for Malignant Glioma Therapy," Cancer Research, 66[11] (2006) 5798-806

  257. C. Y. Wang and S. Wang, "Astrocytic Expression of Transgene in the Rat Brain Mediated by Baculovirus Vectors Containing an Astrocyte-Specific Promoter," Gene Therapy, 13[20] (2006) 1447-1456

  258. L. S. Wang, P. Y. Chow, T.-T. Phan, I. J. Lim and Y.Y. Yang, "Fabrication and Characterization of Nano-structured and Thermo-sensitive Membranes for Wound Healing and Cell Grafting," Advanced Functional Materials, 16[9] (2006) 1171-1178

  259. Y. Y. Yang, Y. Wang, R. Powell and P. Chan, "Polymeric Core-Shell Nanoparticles for Therapeutics," Clinical & Experimental Pharmacology and Physiology, 33[5-6] (2006) 557-562

  260. H. W. Yu, H. Chen, X. Wang, Y. Y. Yang and C. B. Ching, "Cross-Linked Enzyme Aggregates (CLEAs) with Controlled Particles: Application to Candida Rugosa Lipase," Journal of Molecular Catalysis B-Enzymatic, 43[1-4] (2006) 124-127

  261. D. Tan, B. Zhao, S. Moochhala and Y. Y. Yang, "Pharmacokinetic Profile of a Sustained-Delivery System for Physostigmine in Rats," Materials Science and Engineering B, 132[1-2] (2006) 155-158

  262. D. Tan, B. Zhao, S. Moochhala and Y. Y. Yang, "Sustained-Release of Caffeine from a Polymeric Tablet Matrix: An In Vitro and Pharmacokinetic Study," Materials Science and Engineering B, 132[1-2] (2006) 143-146

  263. G. Tresset, "Ion-Induced Accumulation of DNA in Lipid Vesicles," Proceedings of the 50th Biophysical Society Annual Meeting, (2006) DOI: -

  264. N. T. Zaman, F. E. Tan, S. M. Joshi and J. Y. Ying, "Targeted Stimuli-Responsive Dextran Conjugates for Doxorubicin Delivery to Hepatocytes," Proceedings of the Singapore-MIT Alliance Symposium, (2006) DOI: -

  265. X. Jiang, H. Dai, K. W. Leong, S. H. Goh, H. Q. Mao and Y. Y. Yang, "Chitosan-g-PEG/DNA Complexes Deliver Gene to the Rat Liver via Intrabiliary and Intraportal Infusions," Journal of Gene Medicine, 8[4] (2006) 477-487

  266. S. T. Ong, F. Li, J. Du, Y. W. Tan and S. Wang, "Hybrid Cytomegalovirus Enhancer-h1 Promoter-based Plasmid and Baculovirus Vectors Mediate Effective RNA Interference," Human Gene Therapy, 16[12] (2005) 1404-1412

  267. W. M. Shu, W. N. Everett, Q. X. Zhang, M. H. H. Liu, A. Trigg, Y. X. Ma, S. M. Spearing, S. Wang, H. J. Sue and P. M. Moran, "Microheated Substrates for Patterning Cells and Controlling Development," Journal of Microelectromechanical Systems, 14[5] (2005) 924-934

  268. C. Y. Wang and S. Wang, "Adeno-Associated Virus Inverted Terminal Repeats Improve Neuronal Transgene Expression Mediated by Baculoviral Vectors in Rat Brain," Human Gene Therapy, 16[10] (2005) 1219-1226

  269. J. S. Wei, H. B. Zeng, S. Q. Liu, X. G. Wang, E. H. Tay and Y. Y. Yang, "Temperature- and pH-sensitive Core-Shell Nanoparticles Self-Assembled from Poly (N-isopropylacrylamide-co-acrylic acid-cocholesteryl acrylate) for Intracellular Delivery of Anticancer Drugs," Frontiers in Bioscience, 10 (2005) 3058-3067

  270. L. M. Gan, P. Y. Chow, Z. L. Liu, M. Han and C. H. Quek, "The Zwitterion Effect in Proton Exchange Membranes as Synthesised by Polymerisation of Bicontinuous Microemulsions," Chemical Communications, 35 (2005) 4459

  271. M. Kurisawa, J. E. Chung, Y. Y. Yang, S. J. Gao and H. Uyama, "Injectable Biodegradable Hydrogels Composed of Hyaluronic Acid-Tyramine Conjugates for Drug Delivery and Tissue Engineering," Chemical Communications, 34 (2005) 4312-4314

  272. S. Q. Liu, Y. W. Tong and Y. Y. Yang, "Thermally Sensitive Micelles Self-Assembled from Poly(N-isopropylacrylamide-co-N, Ndimethylacrylamide)- b-poly (D,L-lactide-coglycolide) for Controlled Delivery of Paclitaxel," Molecular BioSystems, 1[2] (2005) 158-165

  273. T. B. Bini, S. J. Gao, S. Wang and S. Ramakrishna, "Development of Fibrous Biodegradable Polymer Conduits for Guided Nerve Regeneration," Journal of Materials Science: Materials in Medicine, 16[4] (2005) 367-375

  274. X. Wang, C. Y. Wang, J. M. Zeng, X. Y. Xu, P. Y. K. Hwang, W.C. Yee, Y. K. Ng and S. Wang, "Gene Transfer to Dorsal Root Ganglia by Intrathecal Injection: Effects on Regeneration of Peripheral Nerves," Molecular Therapy, 12 (2005) 314-320

  275. C. Y. Wang, H. Y. Guo, T. M. Lim, Y. K. Ng, H. P. Neo, P. Y. K. Hwang, W.-C. Yee and S. Wang, "Improved Neuronal Transgene Expression from an AAV-2 Vector with a Hybrid CMV Enhancer/ PDGF-β Promoter," Journal of Gene Medicine, 7[7] (2005) 945-955

  276. S. Q. Lu, Y. W. Tong and Y. Y. Yang, "Incorporation and In VitroRelease of Doxorubicin in Thermally Sensitive Micelles Made from Poly(N-isopropyl acrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactideco- glycolide) with Varying Compositions," Biomaterials, 26[24] (2005) 5064-5074

  277. B. Li, Y. X. Ma, S. Wang and P. M. Moran, "Influence of Carboxyl Group Density on Neuron Cell Attachment and Differentiation Behavior: Gradient-Guided Neurite Outgrowth," Biomaterials, 26[24] (2005) 4956-4963

  278. P. Y. Chow and L. M. Gan, "Microemulsion Polymerizations and Reactions," Advances in Polymer Science, 175 (2005) 257-298

  279. M. Y. Wang, Y. Y. Yang and P. W. S. Heng, "Understanding of Fatty Acids as Chemical Enhancers for Transdermal Delivery of Physostigmine," International Journal of Pharmaceutics, 290[2 Jan] (2005) 25-36

  280. Y. Li, Y. Yang and S. Wang, "Neuronal Gene Transfer by Baculovirus-Derived Vectors Accommodating a Neuron-Specific Promoter," Experimental Physiology, 90[1] (2004) 39-44

  281. N. Wu, L. S. Wang, C. W. Tan, S. M. Moochhala and Y. Y. Yang, "Mathematical Modeling and In Vitro Study of Controlled Drug Release via a Highly Swellable and Dissoluble Polymer Matrix: Polyethylene Oxide (PEO) with High Molecular Weights," Journal of Controlled Release, 102[3] (2004) 569-581

  282. F. Alexis, "Factors Affecting Degradation and Drug Release Mechanism of Bioerodible Polymers," Polymer International: Critical Review Paper, 54[1] (2004) 36-46

  283. J. Y. Wu, S. Q. Liu, W. S. Heng and Y. Y. Yang, "Evaluating Proteins Release from and Their Interactions with Thermosensitive Poly (N-isopropylacrylamide) Hydrogels," Journal of Controlled Release, 102[2] (2004) 361-372

  284. L. S. Wang, P. Y. Chow, C. W. Tan, W. D. Zhang and Y. Y. Yang, "Nano-Structured and Transparent Polymer Membranes with Thermo-Sensitivity for Wound Dressing and Cell Grafting," Advanced Materials, 16[20] (2004) 1790-1794

  285. F. Yang, R. Murugan, S. Wang and S. Ramakrishna, "Electrospinning of Nano/Micro Scale Poly(L-lactic acid) Aligned Fibers and their Potential in Neural Tissue Engineering," Biomaterials, 26[15] (2004) 2603-2610

  286. J. Zeng, H. P. Too, Y. Ma, E. S. Luo and S. Wang, "A Synthetic Peptide Containing Loop 4 of Nerve Growth Factor for Targeted Gene Delivery," Journal of Gene Medicine, 6[11] (2004) 1247-1256

  287. X. Liu, J. A. Mohamed and R. S. Ruan, "Analysis of Differential Gene Expression in the Cochlea and Kidney of Mouse by cDNA Microarrays," Hearing Research, 197[1-2] (2004) 35-43

  288. Z. Q. Chen, M. Ulfendahl, R. S. Ruan, L. Tan and M. L. Duan, "Protection of Auditory Function Against Noise Trauma with Local Caroverine Administration in Guinea Pigs," Hearing Research, 197[1-2] (2004) 131-136

  289. Y. Li, X. Wang, H. Guo and S. Wang, "Axonal Transport of Recombinant Baculovirus Vectors," Molecular Therapy, 10 (2004) 1121-1129

  290. B. Li, Y. X. Ma, S. Wang and P. M. Moran, "A Technique for Preparing Protein Gradients on Polymeric Surfaces: Effects on PC12 Pheochromocytoma Cells," Biomaterials, 26[13] (2004) 1487-1495

  291. J. M. Zeng and S. Wang, "Enhanced Gene Delivery to PC12 Cells by a Cationic Polypeptide," Biomaterials, 26[6] (2004) 679-686

  292. P. Y. Chow, L. M. Gan, "Microemulsion Processing of Silica-Polymer Nanocomposite," Journal of Nanoscience and Nanotechnology, 4[1-2] (2004) 197-202

  293. M. Y. Wang, Y. Y. Yang, and W. S. Heng, "Role of Solvent in Interactions between Fatty Acid-based Formulations and Lipids in Porcine Stratum Corneum," Journal of Controlled Release, 94[1] (2003) 207-216

  294. C. S. Chaw, K. W. Chooi, X. M. Liu, C. W. Tan, L. Wang, and Y. Y. Yang, "Thermally Responsive Core-Shell Nanoparticles Self-Assembled from Cholesteryl End-Capped and Grafted Polyacrylamides: Drug Incorporation and In Vitro Release," Biomaterials, 25[18] (2004) 4297-4308

  295. L. Wang, C. S. Chaw, Y. Y. Yang, S. M. Moochhala, B. Zhao, S. Ng, and J. Heller, "Preparation, Characterization, and In Vitro Evaluation of Physostigmine-Loaded Poly(orthoester) and Poly(orthoester)/Poly (D,L-lactide-co-glycolide) Blend Microspheres Fabricated by Spray Drying," Biomaterials, 25[16] (2004) 3275-3282

  296. N. Ma, S. S. Wu, Y. X. Ma, J. M. Zeng, G. P. Tang, Y. Huang, and S. Wang, "Nerve Growth Receptor-Mediated Gene Transfer," Molecular Therapy, 9 (2003) 270-281

  297. S. Q. Liu, Y. Y. Yang, X. M. Liu, and T. Y. Wah, "Preparation and Characterization of Temperature-Sensitive Poly(N-isopropylacrylamide)-b-Poly(D.L-lactide) Microspheres for Protein Delivery," Biomacromolecules, 4[6] (2003) 1784-1793

  298. X. M. Liu, Y. Y. Yang, and K. W. Leong, "Thermally Responsive Polymeric Micellar Nanoparticles Self- Assembled from Cholesteryl End-Capped Random Poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): Synthesis, Temperature-Sensitivity, and Morphologies," Journal of Colloid and Interfacial Science, 266[2] (2003) 295-303

  299. Y. Li, J. Wang, C. G. Lee, C. Y. Wang, S. J. Gao, G.P. Tong, Y. X. Ma, H. Yu, H. Q. Mao, K. W. Leong, and S. Wang, "CNS Gene Transfer Facilitated by A Novel Controlled Release System Based on DNA Complexes of Degradable Polycation PPE-EA: A Comparison with Polyethylenimine/DNA Complexes," Gene Therapy, 11 (2003) 109-114

  300. B. H. Liu, X Wang, Y. X. Ma, and S. Wang, "CMV Enhancer/Human PDGF-b Promoter for Neuron-Specific Transgene Expression," Gene Therapy, 11 (2003) 52-60

  301. C. S. Chaw, C. W. Tan, Y. Y. Yang, L. Wang, and S. M. Moochhala, "Design of Physostigmine-Loaded Polymeric Microparticles for Pretreatment against Exposure to Organophosphate Agents," Biomaterials, 24[7] (2002) 1271-1277

Research Staff

YING Jackie Yi-Ru, Executive Director

WANG Shu, Group Leader

YANG Yi Yan, Group Leader

KURISAWA Motoichi, Team Leader and Principal Research Scientist

EVENTS

2018
23 Jan
IBN Seminar Series: Conformational Communication: Design and Synthesis of Membrane-Bound Receptor Mimics by Prof. Jonathan Clayden, University of Bristol, UK

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FEATURED PUBLICATIONS

Graphene Oxide-Templated Synthesis of Ternary Oxide Nanosheets for High Performance Li-ion Battery Anodes
Nano Energy, 44 (2018) 399-410.
(IF: 12.343) article

Hexaazatrinaphthylene-Based Porous Organic Polymers as Organic Cathode Materials for Lithium Ion Battery
ACS Sustainable Chemistry and Engineering, (2017)
DOI: 10.1021/acssuschemeng.7b03165.
(IF: 5.951) article

Highly Efficient Gas Phase Oxidation of Renewable Furfural to Maleic Anhydride over Plate VPO Catalyst
ChemSusChem, (2017)
DOI: 10.1002/cssc.201701866.
(IF: 7.226) article

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