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RESEARCH AREAS > Drug and Gene Delivery

Drug and Gene Delivery

Drug and Gene Delivery, where the controlled release of therapeutics involve the use of functionalized polymers, hydrogels and biologics for targeting diseased cells and organs, and for responding to specific biological stimuli.

View research projects, research publications and research staff in this research area.

Research Projects

1. Biodegradable Cationic Core-Shell Nanoparticles for Co-delivery of Drugs and Genes

Ashlynn Lee, Nikken Wiradharma, Zhan Yuin Ong, Chuan Yang, Majad Khan, Wei Cheng, Pei Yun Teo, Shujun Gao and Yi Yan Yang

This research focuses on the development of novel biodegradable cationic nanoparticles with a hydrophobic core and a positively charged shell for the co-delivery of drugs and genes to combat multi-drug resistant cancers. IBN researchers have designed and synthesized biodegradable amphiphilic polymers/peptides of varying degrees of positive charge. These polymers/peptides are able to self-assemble into core-shell nanoparticles in aqueous solutions before or after DNA binding. The core is able to encapsulate hydrophobic drug molecules, while the positively charged shell binds negatively charged gene/protein molecules. These nanoparticles have attained high efficiency in protein and gene delivery to various types of cells such as breast and prostate cancer cell lines as well as bone marrow stem cells. By enabling the co-delivery of drugs and genes/proteins in a single system, synergistic therapeutic effects have been achieved in suppressing tumor growth.

2. Development of Baculoviral Vectors for Gene Delivery into Human Embryonic Stem Cells (hESCs) and hESC-derived Cells

Jieming Zeng, Ying Zhao, Xiao Ying Bak and Shu Wang

Genetic manipulation of stem cells in vitro is one of the critical approaches for realizing the potential of stem cells in regenerative medicine and basic research. Possible issues in genetic manipulation include controlling the differentiation of stem cells, isolating pure populations of specific types of differentiated cells, overcoming immune rejection after stem cell transplantation, and providing cell sources for ex vivo gene therapy. The main objective of this project is to establish the proof of principle of using baculoviral vectors for genetic modification of human embryonic stem (hES) cells and hES-derived cells without jeopardizing their stem cell properties. This research aims to develop effective gene transfer systems that may offer flexible control of transgene expression, for either short- or long-term, during stem cell differentiation, and to use the genetically modified stem cells for regenerative medicine.

3. Injectable Biodegradable Hydrogels for Drug Delivery and Tissue Engineering

Motoichi Kurisawa, Joo Eun Chung, Fan Lee, Li Shan Wang, Keming Xu and Kun Liang

Hydrogels have been used extensively for the controlled release of bioactive molecules and the encapsulation of cells. In particular, the use of hydrogels as scaffolds for tissue engineering has shown potential for achieving tissue repair or tissue regeneration in the body. However, most existing hydrogels require surgical implantation, which often results in tissue irritation and damage. This study proposes an alternative involving a biocompatible in situ gel-forming system composed of hyaluronic acid-tyramine (HA-Tyr) conjugates. Using a simple peroxidase-catalyzed oxidation reaction, this novel system allows hydrogels to be formed without any inflammation or reactions to the bioactive agents loaded. Enzyme-mediated HA gel formation in vivo shows promise for achieving effective drug therapy and tissue regeneration. The new materials are being examined for controlled protein release, immunocancer therapy, and tissue engineering.

4. MicroRNAs and Brain Tumors

Yukti Choudhury, Jiakai Lin and Shu Wang

RNA interference is a process in which the recognition of double-stranded RNA ultimately leads to the post-transcriptional suppression of gene expression. This suppression is mediated by short (21- to 22-nt), small interfering RNAs, which induce the degradation of mRNA based on complementary base pairing. Small interfering RNA technology is emerging as a potentially useful method to develop highly specific double-stranded RNA-based gene silencing therapeutics. This project aims to identify targets in brain tumors where gene silencing is likely to have therapeutic benefit. Small interfering RNA technology, in particular its delivery into specific cells, will also be optimized with the objective of developing a clinical solution.

5. Nanostructured Biomaterials for Ocular Drug Delivery and Implants

Shona Pek, Siti Thaharah Mohamed, Wu Hong and Jackie Y. Ying

We have developed several methods of synthesizing nanocomposite biomaterials with controllable microstructure and composition. This enables us to incorporate and deliver substances such as drugs, proteins, growth factors, cells and organic dyes via membrane or scaffold platforms. For example, we have developed microspheres for sustained and/or delayed release of small drugs and growth factors. We have also developed transparent microemulsion-based membranes with tunable properties as the world’s first photochromic contact lenses.

6. Nanostructured Temperature-Sensitive Membranes for Wound Healing and Cell Grafting

Amalina Bte Ebrahim Attia, Shujun Gao and Yi Yan Yang

IBN researchers have developed transparent nanostructured polymeric membranes by the polymerization of bicontinuous microemulsions using a polymerizable surfactant. The membranes have temperature-dependent swelling properties. At lower temperatures, they swell, thereby reducing adhesion and allowing the dressing to be removed from the skin easily and without pain. In addition, these transparent membranes facilitate observation of the wound, while providing a moist wound-healing environment without an adhesive coating layer. When applied to an exuding wound, the membrane would rapidly absorb moisture and adhere to the surface without secondary retention materials. Therapeutics can be encapsulated within the membranes to accelerate the wound healing process. Cells can also be attached onto the thermo-sensitive membranes at 37°C, and would detach at 15°C and resume normal growth. In addition, the membranes have excellent durability and flexibility, demonstrating a great potential to be used as wound dressing or support for cell grafting. Animal studies will be conducted to evaluate the healing efficacy of burn wounds using the membranes with and without human dermal fibroblasts.

7. Polymeric Core-Shell Nanoparticles for Cancer Therapy

Shrinivas Venkataraman, Jeremy Tan, Chuan Yang, Amalina Bte Ebrahim Attia, Sangeetha Krishnamurthy, Shujun Gao and Yi Yan Yang

This research aims to develop smart and safe polymer-based carriers to target small molecular anticancer drugs specifically to tumor cells. Novel core-shell polymer nanoparticles are designed with pH-dependent lower critical solution temperatures (LCST). This value is above the nominal physiological temperature of 37°C at pH 7.4, but decreases to a temperature below the physiological temperature with a small decrease in pH. The resulting change in LCST causes the core-shell nanoparticles to deform and precipitate in an acidic environment, triggering the release of chemotherapeutics at low pH. Stimuli-sensitive nanoparticles are being synthesized with a narrow size distribution by novel approaches. A biological signal that can recognize tumor cells is chemically attached to the core-shell nanoparticles. These carriers may be employed to target drugs to tumor cells and release the drugs intracellularly.

8. Recombinant Baculovirus Vectors: Applications in Cancer Gene Therapy

Chunxiao Wu, Seong Loong Lo, Ying Zhao, Jiakai Lin, Esther Lee and Shu Wang

Recent studies have shown that the recombinant baculovirus Autographa californica and multiple nuclear polyhedrosis viruses with a mammalian expression promoter show great promise as the new generation of gene therapy vehicles. Baculoviruses display a broad tropism in both proliferating and non-proliferating, quiescent mammalian cells. They do not replicate in vertebrate cells, and produce little to no cytotoxicity. The focus of this project is to investigate the possibility of using baculovirus vectors for gene transduction in the nervous system. Engineering the viral vector to enhance its capability in transducing specific types of neural cells has been explored. This research aims to develop safe and effective DNA delivery systems applicable to the gene therapy of neurological disorders and brain cancers.

9. Self-Assembled Green Tea Nanocomplex for Synergistic Effects

Joo Eun Chung, Motoichi Kurisawa, Susi Tan and Jackie Y. Ying

This research aims to develop smart and safe polymer-based carriers to target small molecular anticancer drugs specifically to tumor cells. Novel core-shell polymer nanoparticles are synthesized from functional biodegradable polymers with well-defined molecular weights and functionalities. The nanoparticles have nanosize and a narrow size distribution, and are tailored for high loading of various types of drug molecules. The shell of the nanoparticles contains biological ligands that can specifically recognize receptors over-expressed on cancer cell surfaces. These nanoparticles provide a platform for controlled delivery of a variety of anticancer drugs.

Research Publications

  1. N. Wiradharma, S. Q. Liu and Y. Y. Yang, "Branched and Star-Like Alpha-Helical Peptide Structures with Enhanced Antimicrobial Potency and Selectivity," Small, (2011) DOI: 10.1002/smll.201101672

  2. A. L. Z. Lee, S. Venkataraman, S. B. M. Sirata, S. Gao, J. L. Hedrick and Y. Y. Yang, "The Use of Cholesterol-Containing Biodegradable Block Copolymers to Exploit Hydrophobic Interactions for the Delivery of Anticancer Drugs," Biomaterials, 33 (2011) 1921-1928

  3. C. Wu and S. Wang, "A pH-Sensitive Heparin-Binding Sequence from Baculovirus gp64 Protein Is Important for Binding to Mammalian Cells but Not to fSf9 Insect Cells," Journal of Virology, 86 (2011) 484

  4. Y. Qiao, C. Yang, D. J. Coady, Z. Y. Ong, J. L. Hedrick and Y. Y. Yang, "Highly Dynamic Biodegradable Micelles Capable of Lysing Gram-Positive and Gram-Negative Bacterial Membrane," Biomaterials, 33 (2011) 1146-1153

  5. L. S. Wang, J. E. Chung and M. Kurisawa, "Controlling Fibroblast Proliferation with Dimensionality-Specific Response by Stiffness of Injectable Gelatin Hydrogels," Journal of Biomaterials Science (Polymer Edition), (2011) DOI: 10.1163/156856211x598193

  6. C. Yang, Z. Y. Ong, Y. Y. Yang, P. L. Ee and J .L. Hedrick, "Novel Biodegradable Block Copolymers of Poly(ethylene glycol) (PEG) and Cationic Polycarbonate: Effects of PEG Configuration on Gene Delivery," Macromolecular Rapid Communications, 32 (2011) 1826-1833

  7. D. J. Coady, A. C. Englerand Y. Y. Yang and J. L. Hedrick, "Facile Routes to Star Polymers via an Organocatalytic Approach," Polymer Chemistry, 2 (2011) 2619-2626

  8. N. Wiradharma, M. Khan, L-K. Yong, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang, "The Effect of Thiol Functional Group Incorporation into Cationic Helical Peptides on Antimicrobial Activities and Spectra," Biomaterials, 32 (2011) 9100-9108

  9. E.X. Lee, D. H Lam, C. Wu, J. Yang, C. K. Tham, W. H. Ng and S. Wang, "Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells," Molecular Pharmaceutics, 8 (2011) 1515-1524

  10. S. Venkataraman, J. L. Hedrick, Z. Y. Ong, C. Yang, P. L. R. Ee, P. T. Hammond and Y. Y. Yang, "The Effects of Polymeric Nanostructure Shape on Drug Delivery," Advanced Drug Delivery Reviews, 63 (2011) 1228-1246

  11. S.L. Lo, Y. Choudhury and S. Wang, "Peptide-Based Nanomaterials for siRNA Delivery: Design, Evaluation and Challenges," Nanobiomaterials Handbook, (2011) DOI: 10.1201/b10970-10

  12. C. J. A. Ramachandra, M. Shahbazi, T. W. X. Kwang, Y. Choudhury, X. Y. Bak, J. Yang and S. Wang, "Efficient Recombinase-Mediated Cassette Exchange at the AAVS1 Locus in Human Embryonic Stem Cells Using Baculoviral Vectors," Nucleic Acids Research, 39 (2011) e107

  13. Y. Zhao, D. H. Lam, J. Yang, C. K. Tham, W. H. Ng and S. Wang, "Targeted Suicide Gene Therapy for Glioma Using Human Embryonic Stem Cell-Derived Neural Stem Cells Genetically Modified by Baculorviral Vectors," Gene Therapy, (2011) DOI: 10.1038/gt.2011.82

  14. S. H. Kim, J. P.K. Tan, K. Fukushima, F. Nederberg, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick, "Thermoresponsive Nanostructured Polycarbonate Block Copolymers as Biodegradable Therapeutic Delivery Carriers," Biomaterials, 32 (2011) 5505-5514

  15. M. Sugai, K. Aoki, M. Osato, Y. Nambu, K. Ito, M. M. Taketo and A. Shimizu, "Runx3 is Required for Full Activation of Regulatory T Cells to Prevent Colitis-Associated Tumor Formation," The Journal of Immunology, (2011) DOI: 10.4049/?jimmunol.1001671

  16. T. Yokomizo, C. E. L. Ng, M. Osato and E. Dzierdzak, "Three-Dimensional Imaging of Whole Midgestation Murine Embryos Shows an Intravascular Localization for All Hematopoeitic Clusters," Blood, 117 (2011) 6132-6134

  17. F. Nederberg, Y. Zhang, J. P. K. Tan, K. Xu, H. Wang, C. Yang, S. Gao, X. D. Guo, K. Fukushima, L. Li, J. L. Hedrick and Y. Y. Yang, "Biodegradable Nanostructures with Selective Lysis of Microbial Membranes," Nature Chemistry, 3 (2011) 409-414

  18. X. Y. Bak*, H. L. Dang*, J. Yang, K. Ye, E. X. W. Lee, S. K. Lim and S. Wang, "Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma.," Human Gene Therapy, 22[11] (2011) 1365-1377

  19. A. L. Z. Lee, S. H. K. Dhillon, Y. Wang, S. Pervaiz, W. Fan and Y. Y. Yang, "Synergistic Anti-Cancer Effects Via Co-Delivery of TNF-Related Apoptosis-Inducing Ligand (TRAIL/Apo2L) and Doxorubicin Using Micellar Nanoparticles," Molecular BioSystems, 7[5] (2011) 1512-1522

  20. Z. Y. Ong, P. L. R. Ee, Y. Y. Yang, K. Fukushima, D. J. Coady and J. L. Hedrick, "Rational Design of Biodegradable Cationic Polycarbonates for Gene Delivery," Journal of Controlled Release, 152[1] (2011) 120-126

  21. Y. F. Tan, P. Chandrasekharan, D. Maity, C. X. Yong, K. H. Chuang, Y. Zhao, S. Wang, J. Ding and S.-S. Feng, "Multimodal Tumor Imaging by Iron Oxides and Quantum Dots Formulated in Poly(lactic Acid)-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles," Biomaterials, 32[11] (2011) 2969-2978

  22. J. C. M. Teo, R. R. G. Ng, C. P. Ng and A. W. H. Lin, "Surface Characteristics of Acrylic Modified Polysulfone Membranes Improves Renal Proximal Tubule Cell Adhesion and Spreading," Acta Biomaterialia, 7[5] (2011) 2060-2069

  23. S. Venkataraman, W. L. Ong, Z. Y. Ong, S. C. J. Loo, P. L. R. Ee and Y. Y. Yang, "The Role of PEG Architecture and Molecular Weight in the Gene Transfection Performance of PEGylated Poly(dimethylaminoethyl methacrylate)-Based Cationic Polymers," Biomaterials, 32[9] (2010) 2369-2378

  24. N. Wiradharma, U. Khoe, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang, "Synthetic Cationic Amphiphilic α-Helical Peptides as Antimicrobial Agents," Biomaterials, 32[8] (2010) 2204-2212

  25. A. L. Z. Lee, Y. Wang, S. Pervaiz and Y. Y. Yang, "Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles," Macromolecular Bioscience, 11[2] (2010) 296-307

  26. H. Guo, Y. Choudhury, J. Yang, C. Chen, F. C. Tay, T. M. Lim and S. Wang, "Antiglioma Effects of Combined Use of a Baculoviral Vector Expressing Wild-Type p53 and Sodium Butyrate," Journal of Gene Medicine, 13[1] (2010) 26-36

  27. C. Yang, J. P. K. Tan, W. Cheng, A. Bte Ebrahim Attia, C. Y. T. Tan, A. Nelson, J. L. Hedrick and Y. Y. Yang, "Supramolecular Nanostructures Designed for High Cargo Loading Capacity and Kinetic Stability," Nano Today, 5[6] (2010) 515-523

  28. A. Bte Ebrahim Attia, Z. Y. Ong, J. L. Hedrick, P. P. Lee, R. P. L. Ee, P. T. Hammond and Y. Y. Yang, "Mixed Micelles Self-Assembled from Block Copolymers for Drug Delivery," Current Opinion in Colloid & Interface Science, 16[3] (2010) 182-194

  29. J. Wang, S.-S. Feng, S. Wang and Z.-Y. Chen, "Evaluation of Cationic Nanoparticles of Biodegradable Copolymers as siRNA Delivery System for Hepatitis B Treatment," International Journal of Pharmaceutics, 400[1-2] (2010) 194-200

  30. Y. T. Wong, J. Gruber, A. M. Jenner, F. E. H. Tay and R. S. Ruan, "Chronic Resveratrol Intake Reverses Pro-Inflammatory Cytokine Profile and Oxidative DNA Damage in Ageing Hybrid Mice," Age, 33[3] (2010) 229-246

  31. L. S. Wang, J. Boulaire, P. P. Y. Chan, J. E. Chung and M. Kurisawa, "The Role of Stiffness of Gelatin-Hydroxyphenylpropionic Acid Hydrogels Formed by Enzyme-Mediated Crosslinking on the Differentiation of Human Mesenchymal Stem Cell," Biomaterials, 31[33] (2010) 8608-8616

  32. S. H. Kim, J. P. K. Tan, F. Nederberg, K. Fukushima, J. Colson, C. Yang, A. Nelson, Y. Y. Yang and J. L. Hedrick, "Hydrogen Bonding-Enhanced Micelle Assemblies for Drug Delivery," Biomaterials, 31[31] (2010) 8063-8071

  33. S. Q. Liu, Q. Tian, J. L. Hedrick, J. H. P. Hui, P. L. R. Ee and Y. Y. Yang, "Biomimetic Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stem Cells to Neocartilage," Biomaterials, 31[28] (2010) 7298-7307

  34. L. Li, H. Wang, Z. Y. Ong, K. Xu, P. L. R. Ee, S. Zheng, J. L. Hedrick and Y. Y. Yang, "Polymer- and Lipid-Based Nanoparticle Therapeutics for the Treatment of Liver Diseases," Nano Today, 5[4] (2010) 296-312

  35. M. Khan, N. Wiradharma, G Beniah, N. M. Rafiq, S. Q. Liu, J. Au and Y. Y. Yang, "Branched Disulfide-Based Polyamidoamines Capable of Mediating High Gene Transfection," Current Pharmaceutical Design, 16[21] (2010) 2341-2349

  36. J. P. K. Tan, S. H. Kim, F. Nederberg, K. Fukushima, D. J. Coady, A. Nelson, Y. Y. Yang and J. L. Hedrick, "Delivery of Anticancer Drugs Using Polymeric Micelles Stabilized by Hydrogen-Bonding Urea Groups," Macromolecular Rapid Communications, 31[13] (2010) 1187-1192

  37. N. Wiradharma, Y. W. Tong and Y. Y. Yang, "Design and Evaluation of Peptide Amphiphiles with Different Hydrophobic Blocks for Simultaneous Delivery of Drugs and Genes," Macromolecular Rapid Communications, 31[13] (2010) 1212-1217

  38. X. Y. Bak, J. Yang and S. Wang, "Baculovirus-Transduced Bone Marrow Mesenchymal Stem Cells for Systemic Cancer Therapy," Cancer Gene Therapy, 17[10] (2010) 721-729

  39. S. Wang and G. Balasundaram, "Potential Cancer Gene Therapy by Baculoviral Transduction," Current Gene Therapy, 10[3] (2010) 214-225

  40. S. Q. Liu, Q. Tian, L. Wang, J. L. Hedrick, J. H. P. Hui, Y. Y. Yang and P. L. R. Ee, "Injectable Biodegradable Poly(ethylene glycol)/RGD Peptide Hybrid Hydrogels for In Vitro Chondrogenesis of Human Mesenchymal Stem Cells," Macromolecular Rapid Communications, 31[13] (2010) 1148-1154

  41. W. Y. Seow, Y. Y. Yang and A. J. T. George, "Novel Triblock Oligopeptides as Efficient Nonviral Vectors: Characterization and Further Insights," Macromolecular Rapid Communications, 31[13] (2010) 1170-1174

  42. S. L. Lo and S. Wang, "Intracellular Protein Delivery Systems Formed by Noncovalent Bonding Interactions between Amphipathic Peptide Carriers and Protein Cargos," Macromolecular Rapid Communications, 31[13] (2010) 1134-1141

  43. M. Kurisawa, F. Lee, L. S. Wang and J. E. Chung, "Injectable Enzymatically Crosslinked Hydrogel System with Independent Tuning of Mechanical Strength and Gelation Rate for Drug Delivery and Tissue Engineering," Journal of Materials Chemistry, 20[26] (2010) 5371-5375

  44. Y. C. Wang, Y. Li, T. M. Sun, M. H. Xiong, J. Wu, Y. Y. Yang and J. Wang, "Core-Shell-Corona Micelle Stabilized by Reversible Cross-Linkage for Intracellular Drug Delivery," Macromolecular Rapid Communications, 31[13] (2010) 1201-1206

  45. C. Q. Wang, B. Jacob, G. S. S. Nah and M. Osato, "Runx, Niche and Stem Cell Quiescence," Blood Cells, Molecules and Diseases, 44[4] (2010) 275-286

  46. H. Wang, K. Xu, L. Liu, J. P. K. Tan , Y. Chen, Y. Li, W. Fan, Z. Wei, J. Sheng, Y. Y. Yang and L. Li, "The Efficacy of Self-Assembled Cationic Antimicrobial Peptide Nanoparticles Against Cryptococcus Neoformans for the Treatment of Meningitis," Biomaterials, 31[10] (2009) 2874-2881

  47. S. Venkataraman, Y. Zhang, L. Liu and Y. Y. Yang, "Design, Syntheses and Evaluation of Hemocompatible Pegylated-Antimicrobial Polymers with Well-Controlled Molecular Structures," Biomaterials, 31[7] (2009) 1751-1756

  48. S. Q. Liu, R. Tay, M. Khan, P. L. R. Ee, J. L. Hedrick and Y. Y. Yang, "Synthetic Hydrogels for Controlled Stem Cell Differentiation," Soft Matter, 6[1] (2009) 67-81

  49. L. S. Wang, J. E. Chung, P. Chan and M. Kurisawa, "Injectable Biodegradable Hydrogels with Tunable Mechanical Properties for the Stimulation of Neurogenesic Differentiation of Human Mesenchymal Stem Cells in 3D Culture," Biomaterials, 31[6] (2009) 1148-1157

  50. C. X. Wu, J. K. Lin, M. Hong, D. Leung, Y. Choudhury, P. Balani, J. M. Zeng, J. Boulaire and S. Wang, "Combinatorial Control of Suicide Gene Expression by Tissue-Specific Promoter and microRNA Regulation for Cancer Therapy," Molecular Therapy, 17[12] (2009) 2058-2066

  51. X. D. Guo, J. P. K. Tan, S. H. Kim, L. J. Zhang, Y. Zhang, J. L. Hedrick, Y. Y. Yang and Y. Qian, "Computational Studies on Self-Assembled Paclitaxel Structures: Templates for Hierarchical Block Copolymer Assemblies and Sustained Drug Release," Biomaterials, 30[33] (2009) 6556-6563

  52. W. Y. Seow, Y. Y. Yang and A. George, "Oligopeptide-Mediated Gene Transfer into Mouse Corneal Endothelial Cells: Expression, Design Optimization, Uptake Mechanism and Nuclear Localization," Nucleic Acids Research, 37[18] (2009) 6276-6289

  53. J. Zeng, J. Du, J. Boulaire, Y. Zhao and S. Wang, "The Combined Use of Viral Transcriptional and Post-Transcriptional Regulatory Elements to Improve Baculovirus-Mediated Transient Gene Expression in Human Embryonic Stem Cells," Journal of Bioscience and Bioengineering, 109[1] (2009) 1-8

  54. Y. Yang, S. L. Lo, J. Y. Yang, J. Yang, S. S. L. Goh, C. X. Wu, S. S. Feng and S. Wang, "Polyethylenimine Coating to Produce Serum-Resistant Baculoviral Vectors for In Vivo Gene Delivery," Biomaterials, 30[29] (2009) 5767-5774

  55. Nikken Wiradharma, Ying Zhang, Shrinivas Venkataraman, James L. Hedrick, and Yi Yan Yang, "Self-Assembled Polymer Nanostructures for Delivery of Anticancer Therapeutics," Nano Today, 4[4] (2009) 302-317

  56. L. Liu, K. Xu, H. Wang, J. P. K. Tan, W. Fan, S. S. Venkatraman, L. Li and Y. Yang, "Self-Assembled Cationic Peptide Nanoparticles as an Efficient Antimicrobial Agent," Nature Nanotechnology, 4 (2009) 457-463

  57. J. M. Zeng, J. Du, J. K. Lin, X. Y. Bak, C. X. Wu and S. Wang, "High-Efficiency Transient Transduction of Human Embryonic Stem Cell-Derived Neurons with Baculoviral Vectors," Molecular Therapy, 17[9] (2009) 1585-1593

  58. M. C. Tan, J. Y. Ying, and G. M. Chow, "Interfacial Properties and In Vitro Cytotoxic Effects of Surface?Modified Near Infrared Absorbing Au?Au2S Nanoparticles," Journal of Materials Science: Materials in Medicine, 20[10] (2009) 2091-2103

  59. W. Y. Seow and Y. Y. Yang, "Functional Polycarbonates and Their Self-Assemblies as Promising Non-Viral Vectors," Journal of Controlled Release, 139[1] (2009) 40-47

  60. S. H. Kim, F. Nederberg, R. Jakobs, J. P. K. Tan, K. Fukushima, A. Nelson, E. W. Meijer, Y. Y. Yang and J. L. Hedrick, "A Supramolecularly Assisted Transformation of Block Copolymer Micelles into Nanotubes," Angewandte Chemie International Edition, 48[25] (2009) 4508-4512

  61. Y. Yan, J. Du, T. S. Chen, M. S. Yi, M. Y. Li, S. Wang, C. M. Li and Y. H. Hong, "Establishment of Medakafish as a Model for Stem Cell-based Gene Therapy: Efficient Gene Delivery and Potential Chromosomal Integration by Baculoviral Vectors," Experimental Cell Research, 315[13] (2009) 2322-2331

  62. J. Boulaire, P. Balani and S. Wang, "Transcriptional Targeting to Brain Cells: Engineering Cell Type-Specific Promoter Containing Cassettes for Enhanced Transgene Expression," Advanced Drug Delivery Reviews, 61[7-8] (2009) 589-602

  63. F. Nederberg, E. Appel, J. P. K. Tan, S. H. Kim, K. Fukushima, J. Sly, R. D. Miller, R. M. Waymouth, Y. Y. Yang and J. L. Hedrick, "A Simple Approach to Stabilized Micelles Employing Mikto-arm Terpolymers and Stereocomplexes with Application in Paclitaxel Delivery," Biomacromolecules, 10[6] (2009) 1460-1468

  64. J. Boulaire, Y. Zhao and S. Wang, "Gene Expression Profiling to Define Host Response to Baculoviral Transduction in the Brain," Journal of Neurochemistry, 109[5] (2009) 1203-1214

  65. X. D. Guo, J. P. K. Tan, L. J. Zhang, M. Khan, S. Q. Liu, Y. Y. Yang and Y. Qian, "Phase Behavior Study of Paclitaxel Loaded Amphiphilic Copolymer in Two Solvents by Dissipative Particle Dynamics Simulations," Chemical Physics Letters, 473[4-6] (2009) 336-342

  66. N. Wiradharma, Y. W. Tong and Y. Y. Yang, "Self-Assembled Oligopeptide Nanostructures for Co-Delivery of Drug and Gene in Achieving Synergistic Therapeutic Effect," Biomaterials, 30[17] (2009) 3100-3109

  67. M. Hu, M. Kurisawa, R. Deng, C. M. Teo, A. Schumacher, Y. X. Thong, L. Wang, K. M. Schumacher and J. Y. Ying, "Cell Immobilization in Gelatin-Hydroxyphenylpropionic Acid Hydrogel Fibers," Biomaterials, 30[21] (2009) 3523-3531

  68. J. P. K. Tan, S. H. Kim, F. Nederberg, E. A. Appel, R. M. Waymouth, Y. Zhang, J. L. Hedrick and Y. Y. Yang, "Hierarchical Supermolecular Structures for Sustained Drug Release," Small, 5[13] (2009) 1504-1507

  69. P. Balani, J. Boulaire, Y. Zhao, J. Zeng, J. K. Lin and S. Wang, "High Mobility Group Box2 Promoter-Controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment," Molecular Therapy, 17[6] (2009) 1003-1011

  70. F. Lee, J. E. Chung and M. Kurisawa, "An Injectable Hyaluronic Acid-Tyramine System for Protein Delivery," Journal of Controlled Release, 134[3] (2008) 186-193

Research Staff

WANG Shu, Group Leader

YANG Yi Yan, Group Leader

KURISAWA Motoichi, Team Leader and Principal Research Scientist

 SPOTLIGHT

The Use of a Library of Industrial Materials to Determine the Nature of Substrate-Dependent Performance of Primary Adherent Human Cells
Biomaterials, (2011)
DOI:10.1016/j.biomaterials.2011.09.063

From Short Peptides to Nanofibers to Macromolecular Assemblies in Biomedicine
Biotechnology Advances, (2011)
DOI:10.1016/j.biotechadv.2011.10.004.

The Production of 5-Hydroxymethylfurfural from Fructose in Isopropyl Alcohol: A Green and Efficient System
ChemSusChem, (2011)
DOI:10.1002/cssc.201100489

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