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MEDIA CENTER > Highlights
2018 | 2017 | 2016 | 2015 | 2014 | 2013
More Evidence for Metformin

A popular diabetes drug could one day be used to treat malignant tumors


Colorectal cancer patient-derived organoids that were used to test for response to metformin in the study

January 16, 2018 – Metformin’s potential as a tumor-suppressing agent, to prevent the growth of breast, colon, lung and prostate cancers, has been demonstrated in pre-clinical studies. However, the experimental models used in these studies do not accurately recreate the natural manifestations of the disease, and require toxic levels of metformin to demonstrate beneficial effects.

Dr Min-Han Tan and a group of researchers from the Institute of Bioengineering and Nanotechnology (IBN), the Biological Resource Centre, and the Genome Institute of Singapore, with collaborators from hospitals across Singapore, have now tested metformin’s cancer-fighting abilities on a model of colorectal cancer that is more representative of how the disease appears in humans.

The team took samples of cancer tissue from two patients and implanted them in mice, then assessed how the tumors responded to metformin as well as 5-fluorouracil, the current front-line treatment for colorectal cancer.

Read more.

Taking A Stab at Microbes

Arrays of tiny, rigid, and sharp pillars mimic natural antimicrobial surfaces by binding and breaking bacterial cells open


IBN researchers have developed positively charged nano-dagger arrays that effectively kill microbes, such as Escherichia coli and Staphylococcus aureus

January 16, 2018 – A powerful solution to the global spread of antimicrobial resistance could soon become available, thanks to researchers from the Institute of Bioengineering and Nanotechnology (IBN), who have come up with a physical and green alternative to biochemically active antibacterial agents.

Typically transmitted by contact with contaminated surfaces, bacterial infections pose serious health threats in medical settings. Small molecular antibacterial agents, which are commonly used in antiseptics, disinfectants, and preservatives, and other consumer care products, can prevent cross-infection by annihilating bacteria on frequently touched surfaces. However, their overuse contributes to antimicrobial resistance. These toxic and persistent substances can also harm the environment by disrupting the ecological balance of soils and endangering aquatic life.

In response to this, Dr Yugen Zhang and Dr Yuan Yuan, from IBN have developed nanostructured surfaces that destroy bacteria through physical, rather than biochemical interactions.

Read more.

 

EVENTS

2018
23 Jan
IBN Seminar Series: Conformational Communication: Design and Synthesis of Membrane-Bound Receptor Mimics by Prof. Jonathan Clayden, University of Bristol, UK

Event Calendar   

FEATURED PUBLICATIONS

Graphene Oxide-Templated Synthesis of Ternary Oxide Nanosheets for High Performance Li-ion Battery Anodes
Nano Energy, 44 (2018) 399-410.
(IF: 12.343) article

Hexaazatrinaphthylene-Based Porous Organic Polymers as Organic Cathode Materials for Lithium Ion Battery
ACS Sustainable Chemistry and Engineering, (2017)
DOI: 10.1021/acssuschemeng.7b03165.
(IF: 5.951) article

Highly Efficient Gas Phase Oxidation of Renewable Furfural to Maleic Anhydride over Plate VPO Catalyst
ChemSusChem, (2017)
DOI: 10.1002/cssc.201701866.
(IF: 7.226) article

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