A*STAR Outstanding Publications Award
2009, 2010, 2012, 2013, 2014, 2016 and 2017
A*STAR Patent Power Award
2009, 2010 and 2017
Singapore HEALTH Award
(Platinum) 2012, (Gold) 2008 and 2010
BCA Green Mark Award
2013 (Gold) and 2017 (Gold and Goldplus)

INNOVATIONS FOR TOMORROW

Highlights

More Evidence for Metformin
A popular diabetes drug could one day be used to treat malignant tumors


Colorectal cancer patient-derived organoids that were used to test for response to metformin in the study

January 16, 2018 – Metformin’s potential as a tumor-suppressing agent, to prevent the growth of breast, colon, lung and prostate cancers, has been demonstrated in pre-clinical studies. However, the experimental models used in these studies do not accurately recreate the natural manifestations of the disease, and require toxic levels of metformin to demonstrate beneficial effects.

Dr Min-Han Tan and a group of researchers from the Institute of Bioengineering and Nanotechnology (IBN), the Biological Resource Centre, and the Genome Institute of Singapore, with collaborators from hospitals across Singapore, have now tested metformin’s cancer-fighting abilities on a model of colorectal cancer that is more representative of how the disease appears in humans.

The team took samples of cancer tissue from two patients and implanted them in mice, then assessed how the tumors responded to metformin as well as 5-fluorouracil, the current front-line treatment for colorectal cancer.

Read more.

Taking A Stab at Microbes
Arrays of tiny, rigid, and sharp pillars mimic natural antimicrobial surfaces by binding and breaking bacterial cells open


IBN researchers have developed positively charged nano-dagger arrays that effectively kill microbes, such as Escherichia coli and Staphylococcus aureus

January 16, 2018 – A powerful solution to the global spread of antimicrobial resistance could soon become available, thanks to researchers from the Institute of Bioengineering and Nanotechnology (IBN), who have come up with a physical and green alternative to biochemically active antibacterial agents.

Typically transmitted by contact with contaminated surfaces, bacterial infections pose serious health threats in medical settings. Small molecular antibacterial agents, which are commonly used in antiseptics, disinfectants, and preservatives, and other consumer care products, can prevent cross-infection by annihilating bacteria on frequently touched surfaces. However, their overuse contributes to antimicrobial resistance. These toxic and persistent substances can also harm the environment by disrupting the ecological balance of soils and endangering aquatic life.

In response to this, Dr Yugen Zhang and Dr Yuan Yuan, from IBN have developed nanostructured surfaces that destroy bacteria through physical, rather than biochemical interactions.

Read more.

IBN Executive Director Professor Jackie Y. Ying Elected Fellow of the U.S. National Academy of Inventors


December 13, 2017 – Professor Jackie Y. Ying, Executive Director of the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR, has been named a Fellow of the U.S. National Academy of Inventors (NAI). This is the highest professional accolade bestowed to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and welfare of society.

Prof Ying is the first researcher based in Singapore to receive this recognition. She was selected a NAI Fellow for her outstanding contributions to innovative discovery and technology, patent inventions and licensing, significant impact on society, as well as support and enhancement of innovation.

“It is a great honor to be named a fellow of the U.S. National Academy of Inventors,” said Prof Ying. “Having gone to the same college as Thomas Edison, I was always inspired to be an inventor. To be able to make a societal impact through technological breakthroughs and innovations is the most exciting aspect of research.”

Read more.

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IBN in the News

Inventors' Honour for A*STAR Scientist
The Straits Times, 14 Dec 2017

Singapore-Based Scientist Earns Top Accolade for Academic Inventors
The New Paper, 14 Dec 2017

Singapore-Based Researcher Bags Top Accolade for Academic Inventors
TODAY, 14 Dec 2017

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EVENTS

2018
23 Jan
IBN Seminar Series: Conformational Communication: Design and Synthesis of Membrane-Bound Receptor Mimics by Prof. Jonathan Clayden, University of Bristol, UK

Event Calendar   

FEATURED PUBLICATIONS

Graphene Oxide-Templated Synthesis of Ternary Oxide Nanosheets for High Performance Li-ion Battery Anodes
Nano Energy, 44 (2018) 399-410.
(IF: 12.343) article

Hexaazatrinaphthylene-Based Porous Organic Polymers as Organic Cathode Materials for Lithium Ion Battery
ACS Sustainable Chemistry and Engineering, (2017)
DOI: 10.1021/acssuschemeng.7b03165.
(IF: 5.951) article

Highly Efficient Gas Phase Oxidation of Renewable Furfural to Maleic Anhydride over Plate VPO Catalyst
ChemSusChem, (2017)
DOI: 10.1002/cssc.201701866.
(IF: 7.226) article

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