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Singapore scientists uncover how the liver unclogs itself
Findings could potentially improve prognosis of infants with rare liver disease


Figure: Schematic diagram illustrating how hepatocytes or liver cells clear excess bile from blocked ducts. (A) Bile ducts are blocked in diseases such as biliary atresia. (B) Bile builds up behind the blockage, putting pressure on the surrounding cells that make up the walls of the duct. (C) If the pressure increases, the actin cortex, which lies inside the cell, may rupture. Once the actin filament network is fragmented, the bile will push the cell membrane into the cell, through the disrupted actin network. (D) If the actin network cannot be repaired, then the membrane will continue to be pushed inside until it breaks off into bubble-like vesicles. These vesicles carry the bile through the cell and away from the blockage.

Singapore, June 30, 2017 – A multi-disciplinary team of researchers from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore (NUS), the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR, and BioSyM, Singapore-MIT Alliance for Research and Technology have described the mechanical principles adopted by liver cells as they remove excess bile during obstructive cholestasis. This study was published online in the Journal of Hepatology earlier this year.

The research team comprises team leader Professor Hanry Yu, who is a Principal Investigator at MBI and IBN; Mr Kapish Gupta, who is a graduate student at MBI and first author of the paper; as well as their fellow MBI researchers - Associate Professor Virgile Viasnoff, Associate Professor Low Boon Chuan, and Assistant Professor Pakorn (Tony) Kanchanawong.

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Nano Today Reports New Impact Factor: 17.476
The journal continues to rank among world’s most influential scientific journals

Singapore, June 23, 2017 – Singapore-based Nano Today journal’s impact factor has increased from 13.157 to 17.476. The journal continues to rank among the world’s most influential scientific journals according to the latest 2017 Journal Citation Reports® by Thomson Reuters.

“I am delighted with the new impact factor and would like to thank our authors, reviewers and editorial advisory board for their contributions toward making Nano Today a success. I am particularly grateful to our Managing Editor, Noreena AbuBakar, for her outstanding efforts in managing the journal. Nano Today will continue to publish the top articles in this multidisciplinary frontier, and emphasize the importance of the link between design, synthesis, and the wide-ranging applications of nanomaterials and nanosystems,” said Professor Jackie Y. Ying, Editor-in-Chief of Nano Today, and Executive Director of the Institute of Bioengineering and Nanotechnology of A*STAR, Singapore.

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New Technique by Singapore Researchers May Produce More Durable and Longer Lasting Lithium-Ion Batteries


Clockwise from bottom right: The IBN research team who developed this novel technique comprises Prof Jackie Ying, Mr Ayman Amin AbdelHamid, Dr Yue Yu and Dr Jinhua Yang. © Institute of Bioengineering and Nanotechnology

June 22, 2017 – Lithium-ion batteries are used to power many things from mobile phones, laptops, tablets to electric cars. But they have some drawbacks, including limited energy storage, low durability and long charging time. Now, researchers at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR have developed a new way of producing more durable and longer lasting lithium-ion batteries. This finding was reported today in the Advanced Materials journal.

Led by IBN Executive Director Professor Jackie Y. Ying, the researchers invented a generalized method of producing anode materials for lithium-ion batteries. The anodes are made from ultrathin metal oxide nanosheets, which are ultrathin, two-dimensional materials with excellent electrochemical and mechanical properties.

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IBN in the News

Building Ties in Pharma Industry 'Just Like Courtship'
The Straits Times, 09 Aug 2017

Treating Fungal Cornea Infection with Synthetic Molecules
PhysOrg, 12 Jul 2017

A New Twist to Treating Fungal Cornea Infection
A*STAR Research, 12 Jul 2017

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2017
18 Sep
Falling Walls Lab Singapore 2017

6 Dec - 10 Dec
5th Nano Today Conference

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FEATURED PUBLICATIONS

Molecular Characterization of Circulating Colorectal Tumor Cells Defines Genetic Signatures for Individualized Cancer Care
Oncotarget, (2017)
DOI: 10.18632/oncotarget.19138.
(IF: 5.168) article

Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts
Molecular Cancer Therapeutics, (2017)
DOI: 10.1158/1535-7163.MCT-16-0793.
(IF: 5.764) article

Unique Thermal Stability of Unnatural Hydrophobic Ds Bases in Double-Stranded DNAs
ACS Synthetic Biology, (2017)
DOI: 10.1021/acssynbio.7b00165.
(IF: 5.382) article

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